Nicotiana rustica contains harmine tetrahydroharmine and harmaline, as well as nicotine, I don't notice a nicotine potentiation when I smoke it, kind of the complete opposite.
Tobacco like Rapa Nui was used as an MAOI in Ayahuasca on ocassion. And being that it has 9x the tobacco of like a Havanna or Virginia Tabaccum, its basically a Nicotine- Trip. Natives used to roll Rapa Nui logs into their sunless regions and trip for hours.
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