MAOI +Ketamine... safe ?

[monomind]

I apologies if this was answered elsewhere (surely I am not the first to ask about this ) but I could not find anything definete.
Are there any known interactions between Ketamine and Harmalas ?
Specifically, I would like to dose on some ketamine before smoking changa (made with syrian rue alks) so any experience or knowledge on the subject would help!
Thanks

 

[Nydex]

Hello @monomind,

I would strongly discourage mixing any dissociatives with a MAOI as this can cause various issues, including respiratory and cardiovascular. You can read more about this on our Known substance-interactions and their effects section of the Wiki, and more specifically the Ketamine + Harmalas (MAOI) part of it.

Safety should always be your first and foremost concern when working with any substance, so if you find any evidence that a substance combination you're considering might be unsafe, please do not take unnecessary risks.

If you have any more questions, feel free to ask them in the appropriate subfora, or in our chat.

 

[monomind]

Hello @monomind,

I would strongly discourage mixing any dissociatives with a MAOI as this can cause various issues, including respiratory and cardiovascular. You can read more about this on our Known substance-interactions and their effects section of the Wiki, and more specifically the Ketamine + Harmalas (MAOI) part of it.

Safety should always be your first and foremost concern when working with any substance, so if you find any evidence that a substance combination you're considering might be unsafe, please do not take unnecessary risks.

If you have any more questions, feel free to ask them in the appropriate subfora, or in our chat.

Thanks for your answer. There was actually a study done (on a small group though) where no adverse effects where encountered. Here is a link: Concurrent use of ketamine and monoamine oxidase inhibitors in the treatment of depression: A letter to the editor

I don't think I will try it before more evidence (even anecdotal) is found.

 

[Transform]

One also has to be aware of the metabolic effects of harmala alkaloids - notably competitive inhibition of cyp2d6, as well as certain GABA-ergic effects that @Sabnock1990 is better at quoting than I.