Methylene Blue

[PsillyPsimon]

I am wondering if anyone has ever tried using Methylene Blue as a MAO inhibitor to potentiate tryptamines.

I know there's another pharmaceutical MAOI but it is contraindicated for our purposes.

 

[downwardsfromzero]

I would suggest that harmala alkaloids are far less toxic. The side effects of methylene blue include risk of serotonin syndrome, so prudence indicates that it might not be the best candidate for the oral potentiation of tryptamines. Contraindication for (presumably) moclobemide will likely extend to containdication for methylene blue. What is the reason for your contraindication?

Methylene Blue: Revisited

www.ncbi.nlm.nih.gov

"Methylene blue is a MAO inhibitor and therefore can interact with selective serotonin reuptake inhibitor (SSRI) and MAO inhibitors to cause serious serotonin toxicity."

 

[Sabnock1990]

If you can get ahold of some, i'd say go for Moclobemide, i've orally activated DMT with it just fine, but overall i prefer Harmalas. Haven't tried Methylene Blue though so can't speak on that.

 

[PsillyPsimon]

Thanks for your replies. As I understand it, pharmaceutical MAOi's are contradicted for use with tryptamines.

 

[Sabnock1990]

Thanks for your replies. As I understand it, pharmaceutical MAOi's are contradicted for use with tryptamines.

Not really, some people have used pharma MAOI's, they're not contraindicated. Thing is though you would preferably want to go for a RIMA (reversible and selective inhibitor of MAO-A) like Moclobemide, rather than a full on MAOI. Moclobemide has been used for oral DMT activation just fine, and Moclobemide is pretty transparent on the body so at least ime aside from some dizziness there really isn't any side-effects to it, that i've noticed, i've used it to activate oral DMT as well as to potentiate mushrooms and 4-ACO-DMT, worked great.

 

[Jungleheart]

There is methylene blue in my skincare.

 

[crystalofthegods]

I've been looking for answers on this as well. I'm trying to find an informed answer on Methylene Blue. Does anyone know what dose size is required for full MAO Inhibition? The only responses to this is always just 'why don't you take harmine instead?'

Does anyone have knowledge or personal experience with Methylene Blue? And the required dose size?

It is apparently a potent reversible and selective inhibitor of MAO-A. And very low toxicity. But I can't seem to find answers on exactly how potent. And how much would be required to make DMT orally active.

I have found from a research paper the IC50 value of MB on MAO-A is 164±8 nM. But I'm not sure how to translate that in to a required dose size for full MAO Inhibition.

And from Wikipedia it says

Methylene blue is a monoamine oxidase inhibitor (MAOI), and if infused intravenously at doses exceeding 5 mg/kg, may precipitate serious serotonin toxicity, serotonin syndrome, if combined with any selective serotonin reuptake inhibitors (SSRIs) or other serotonin reuptake inhibitors

Giving a vague general idea. I'm pretty sure I saw somebody mention a while back that they were using 300mg. And 5mg/kg orally would only be dangerous if combined with an SSRI? Or something like MDMA correct?

 

[crystalofthegods]

Now to confuse the matter I just found this quote from this paper:

Methylene blue is a potent monoamine oxidase inhibitor - Canadian Journal of Anesthesia/Journal canadien d'anesthésie

link.springer.com

"My initial report in 2006 postulated that the severity of the serotonin toxicity symptoms in these cases was such as to indicate methylene blue must be acting as an MAOI. I stated ‘… further corroboration and quantification of methylene blue’s potency (as an MAOI) is in progress.’ That paper has confirmed the prediction by demonstrating experimentally, that it is a potent tight binding MAO-A inhibitor at nanomolar concentrations: i.e., it is ~ 100 times more potent than moclobemide"


100 times more potent than Moclobemide?