Microdosing Psychedelics

[InneffableThings]

I think it's important to define what "microdosing" really means.

True. I kinda agree with your definition. But what does Wikipedia say?

Microdosing (or micro-dosing) is a technique for studying the behaviour of drugs in humans through the administration of doses so low ("sub-therapeutic") they are unlikely to produce whole-body effects, but high enough to allow the cellular response to be studied.

Microdosing - Wikipedia

I agree with this importance.

Fadiman also uses the term sub-perceptual dose interchangeably, which may be useful in defining what the terms mean. Sub-perceptual could mean an amount which is about as much as can be taken without causing significantly noticeable perceptual change, including visual, audio, and time; and does not impede ability to perform daily tasks.

Fadiman does specifically say 10ug lsd or less, to give a clear quantifier to the term as he uses it.

Thoughts?

 

[idtravlr]

I think it's important to define what "microdosing" really means.

True. I kinda agree with your definition. But what does Wikipedia say?

Microdosing (or micro-dosing) is a technique for studying the behaviour of drugs in humans through the administration of doses so low ("sub-therapeutic") they are unlikely to produce whole-body effects, but high enough to allow the cellular response to be studied.

Microdosing - Wikipedia

I agree with this importance.

Fadiman also uses the term sub-perceptual dose interchangeably, which may be useful in defining what the terms mean. Sub-perceptual could mean an amount which is about as much as can be taken without causing significantly noticeable perceptual change, including visual, audio, and time; and does not impede ability to perform daily tasks.

Fadiman does specifically say 10ug lsd or less, to give a clear quantifier to the term as he uses it.

Thoughts?

Ok. I see where you guys are coming from. I guess the context of the study needs to be taken into consideration then. So, perhaps my definition would better fit the term mini-dosing if one is really basing the dosage on "therapeutic" vs "sub-therapeutic". Maybe I'm over thinking it too...

*idtravlr checks Wikipedia for "mini-dosing"*

However, there is this in the article as well: "(Note that while this is the most common definition, the term also is used to refer to instruments for dispensing full therapeutic amounts of active pharmaceutical ingredient (API), as in direct "API-into-Capsule" technology. [1])" So it seems that the equipment mfrs. refer to the term differently. Hmmm... gonna think on this one a bit. :?

Oh, and I would certainly agree that 10ug or less of LSD would be a micro-dose.

 

[Attention All Shipping]

I've done some microdosing with P. Cubensis in the past on an irregular basis - not every day, just when I wanted a bit of a mental/mood boost. I'd take around 1/4 of a gram as my standard micro-dose level.

As far as definition of micro-dose goes I'd say its a dose which doesn't cause any psychedelic effects.

Semios's experience of "subtle threshold effects and get just a wee bit of visual intensity if I look at something that has a rich pattern or bright beauty already. Plus a mild mood elevation, and increased affability, and a touch more energy. Maybe some giggles." I'd characterise as a low 'museum dose' rather than a micro-dose.

 

[Phlux-]

The microdosing went amazingly
before - i didnt do much excersize but with the cactus i managed a good 100-150 pushups, 50 pullups and 100 situps per day, every day, for a month.

my entire body changed

im takin a month break and then il start round 2

absolutely amazing stuff

 

[universecannon]

nice man

what other positive mental affects did you notice besides the motivation?

i have some resin here so i was thinking about trying it out soon

 

[Purges]

I had a period when i always trained brazilian jiu jitsu after smoking a few hits of bud, For a good while i think it helped with my flow of movements and while i don´t do it anymorei still think i learned alot from doing it.

Now i´m thinking about taking this a step further by taking about 1/5 of a hit of cid and trying it out.

Anyone tried working ouut on cid?

here´s highlight of a favorite bjj player of mine

This may also be of interest to you:

http://www.maps.org/news-letters/v21n1/v21n1-25to29.pdf

 

[tigerstrike92]

That article was truly inspiring. I always knew there had to be something too it.

This may not be that extreme, but some cannabis always improves my disc golf playing.:d

 

[EcstaticTrance]

The microdosing went amazingly
before - i didnt do much excersize but with the cactus i managed a good 100-150 pushups, 50 pullups and 100 situps per day, every day, for a month.

my entire body changed

im takin a month break and then il start round 2

absolutely amazing stuff

I am cooking some peruvian torch tea at the moment and I would like to have some details about your experiment so I can have some guidelines. What kind of dosage did you experimented with in microdosing cacti? Did you take it on an empty stomach in the morning or with food? Did you noticed some kind of tolerance with it?

I had some pretty amazing experiences with cacti and I know for sure how a nice tonic it can be and as I've started some kind of a getting back in shape routine I think it can be a quite nice tool. Thanks a lot in advance
:thumb_up:

 

[marypoppins]

My personal definition of microdosing is:
the smallest amount possible
that is enough to produce a slight mild "shift"
while definetly staying below threshold levels.

My experiences:
1 1/2 years: iboga root bark - 300 mg, sometimes 500 mg., 1 or 2x / day; on and off, several rounds of 30 days. powerful. energizing yet calming. allows one to take a step back and observe one's reality and choose how to respond or react. the iboga definetly lets you know when to stop. i believe that all of this is true for someone who has flooded but would be differant if you have not flooded

3 months: H.B.W.: 4 -5 days at a time, 2x / day - euphoric feeling mood enhancer. cerebral, insightful.
hard on the stomach

LSD: 3 - 4 days at a time 10 - 15 ug. 1x / day; relaxing and insightful. cognitive
increases

5-meo: - 4 - 5 days at a time. amazing clarity and energy. destroys the nasal passageway

Olilique seeds - 6 months on and off. 2 -3 weeks at a time. great. mild. gentle. euphoric. cerebral. calming.

rue + dmt tea - 2 months - fantastic - clear, energetic, mood enhancer, calm, clarity

muricata + dmt ----report in a few weeks

all of the above were:
notropic and allowed for clearer faster thinking, incresed focus
calming, relaxing, mood enhancing
all allowed for being "more in tune"
which then allowed for refined diet, balance and center in all avenues of life

however,
much depends on your life situation
the results would be different for a short order cook in downtown manhattan then a farmer in kansas
i believe that the more out of tune, or fast paced ones life
the harder it would be to function even on a microdose
most likely would have to reduce the amount even further

i found no tolerance in any of these
actually i discovered that each one seemd to have reverse tolerance
sort of a saturation of the neural pathways
to where one could skip days and not notice
(I believe tolerance is a concept more attuned to above threshold dosage, where one is looking for an experience; sub-threshold, where one is looking for a shift or opening, i think the opposite is true -- at least it was for me)

*** one small side note for accuracy - for many years now, i take a daily mix of
brahmi, gota kola, gingko, ashwaganda. this probably has a significant affect on my experiences -both full and micro

mary

 

[Kambogahuascanga]

1 1/2 years: iboga root bark - 300 mg, sometimes 500 mg., 1 or 2x / day; on and off, several rounds of 30 days. powerful. energizing yet calming. allows one to take a step back and observe one's reality and choose how to respond or react. the iboga definetly lets you know when to stop. i believe that all of this is true for someone who has flooded but would be differant if you have not flooded

CRUCIAL!!!!!!!

I learned from the great one. What's the story of Mary Poppins? What a fitting description.

 

[nexalizer]

This may also be of interest to you:

http://www.maps.org/news-letters/v21n1/v21n1-25to29.pdf

Fascinating stuff, thanks for sharing:thumb_up: :thumb_up:

 

[Ice House]

micro dosing ps cyanescens throught the summer while gardening = added energy for long days and added creativity.

 

[MMPA]

Microdosed 10mg rectally every other day for a week on 4-Aco-DET (shroom-like feeling). Though the initial main effects lasted only a couple of hours, the rest of the day (and some of the next day) I would be more empathetic/caring towards people as well as jovial, sociable, and calmed (I am usually energetic). I also was more careful about my selection of words when talking so my speech was slower and more colorful in the good way. Definitely better than daily caffeine.

 

[universecannon]

My personal definition of microdosing is:
the smallest amount possible
that is enough to produce a slight mild "shift"
while definetly staying below threshold levels.

My experiences:
1 1/2 years: iboga root bark - 300 mg, sometimes 500 mg., 1 or 2x / day; on and off, several rounds of 30 days. powerful. energizing yet calming. allows one to take a step back and observe one's reality and choose how to respond or react. the iboga definetly lets you know when to stop. i believe that all of this is true for someone who has flooded but would be differant if you have not flooded

3 months: H.B.W.: 4 -5 days at a time, 2x / day - euphoric feeling mood enhancer. cerebral, insightful.
hard on the stomach

LSD: 3 - 4 days at a time 10 - 15 ug. 1x / day; relaxing and insightful. cognitive
increases

5-meo: - 4 - 5 days at a time. amazing clarity and energy. destroys the nasal passageway

Olilique seeds - 6 months on and off. 2 -3 weeks at a time. great. mild. gentle. euphoric. cerebral. calming.

rue + dmt tea - 2 months - fantastic - clear, energetic, mood enhancer, calm, clarity

muricata + dmt ----report in a few weeks

all of the above were:
notropic and allowed for clearer faster thinking, incresed focus
calming, relaxing, mood enhancing
all allowed for being "more in tune"
which then allowed for refined diet, balance and center in all avenues of life

however,
much depends on your life situation
the results would be different for a short order cook in downtown manhattan then a farmer in kansas
i believe that the more out of tune, or fast paced ones life
the harder it would be to function even on a microdose
most likely would have to reduce the amount even further

i found no tolerance in any of these
actually i discovered that each one seemd to have reverse tolerance
sort of a saturation of the neural pathways
to where one could skip days and not notice
(I believe tolerance is a concept more attuned to above threshold dosage, where one is looking for an experience; sub-threshold, where one is looking for a shift or opening, i think the opposite is true -- at least it was for me)

*** one small side note for accuracy - for many years now, i take a daily mix of
brahmi, gota kola, gingko, ashwaganda. this probably has a significant affect on my experiences -both full and micro

mary

What amounts of rue and dmt were you taking? Was it mimosa, freebase, or?

I've had amazing results micro dosing rue (or caapi) with and without mimosa

 

[jdubs]

If you're gonna do this, don't be as stupid as I was the other day.

Took an unmeasured swig from the Aya bottle like some kind of stupid pirate.

Felt like I was being electrified while trying to act like an upstanding citzen. :d

It wore off before too long, thankfully. But I wont be repeating it.

 

[Dr_Sister]

Sister micro-doses 5-Meo MIPT on a regular basis, although very rarely on consecutive days. Tihkal says a standard dose is 4-6mgs, but sister really enjoys a 0.5-1.0mg dose. (put an exacto knife blade into baggy, then tap the excess off the blade into the bag, and then lick the powder that still clings to the blade).

It makes sister, less inhibited, more social, and better able to appreciate the subtlties of music. The best part is no one ever knows what Sister has been up to 8)

Sister isn't sure that doing this everyday would be a great idea for her. It would be a shame to become dependant on something that is otherwise very magical, and to be looked forward to.