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My experience with lucidity, 5-HT2A drugs, and DMT

s2cndchance

Esteemed member
-Brief background-

Profession: Sleep technician (I monitor the EEGs of sleeping people)
Drugs used: NN DMT, Galantamine, LSD, Shrooms, Weed, Nicotine, Antihistamines, Alcohol


-What I've found-

1. All of these drugs effects on individuals can vary WIDELY

Primary source: my brother, sharing the same (mix) of DNA, has also tried all of these drugs (except DMT) and does not experience them even remotely the same as I do.

Brother on LSD and/or Shrooms: He feels happy and good and takes them like candy and talks about how awesome life and the colors are, can take it at his job.
Me on LSD and/or Shrooms: I feel like butter scraped over too much bread, like I'm a ghost, and that ghost is only half there. Additionally, I can't do math, I can't figure out who's turn it is in a card game, and the time dilation is so bad that I would stab my mouth eating a Dorito and feel it ten seconds later. Ever watch that episode of Rick and Morty with the Devil's Cursed wares? The microscope advertised to make you see the cosmos but actually just makes you mentally ill? That's how I feel doing LSD and Shrooms.

Brother on weed: Feels lazy, hungry, and watches TV all day. Also takes it like candy, and at his job.
Me on weed: I feel hornier than a unicorn trumpeting for assistance from Gondor. I will want to have sex or masturbate for hours and hours. If I take a lot in edible form, I also feel like a ghost. The ghost effects from weed take months to go away. (LSD ghosting wears off suddenly and the come up is the best feeling ever. I will literally be singing "I can see clearly now the rain is gone.")


2. DMT has at least two modes that affect me.
Likely due to the variety of receptors it hits, as with most drugs, I suspect. I have come to the conclusion, that for me, anything that affects the 5-HT2A receptor (or probably serotonin receptors generally) gives the ghosting effect.

First, I feel light weighted. Then I feel pressure much like the pressure I feel when I'm going into a wake back to bed lucid dream before taking off much like a wake back to bed lucid dream. Before blasting off or on lower doses, I can see reality falling apart before my eyes and the onset of the grid-line fractal visuals eyes open or eyes closed, very clearly, VERY LUCIDLY. This has been the drug experience I was always searching for.

Second, I start to feel the ghosting effects similar to LSD, Shrooms, and the lesser but longer Weed. The delay is 2-3 minutes. The trip is usually 15 minutes. 2 minutes after the trip ends, the ghosting will end, too. Because the onset of this ghosting effect is so sharp, I can feel it keenly, getting stronger /weaker, I can analyze it in real time unlike the other drugs.

Thus my intro into the trip is FANTASTIC as I am utterly lucid while it's all going down and can see all sorts of shit and make some relational sense of it and have memory of it. Then the time dilation and loss of sense and awareness sets it and it starts to feel like a dream, and then worse than a dream, and my memory becomes fuzzy.

I read on wikipedia's N,N DMT article that certain trip killer drugs that work on LSD and Shrooms have little to no effect on DMT trips from some study that I didn't evaluate for myself.
My suspicion is that the fractal /hyper-reality / entity visiting effects of DMT is NOT working via the 5 HT2A receptor, and that, at least for people like me, it would be a MASSIVE benefit to blunt or dull these secondary effects.

3. Lucidity drugs that improve the odds of lucid dreaming can offset these fog / time dilation / hazy memory effects.

Galantamine is a drug that has had a few studies done on it, enough to demonstrate it has a good chance to induce a lucid dream in unwilling or unknowing participants vs placebo. I have tested it on myself, and it works very well for me in inducing lucid dreams. I particularly combine it with WBTB (when I wake up, if I feel the pressure when laying back down for a few minutes, I take the galantamine (8mg) and wait 30min to an hour before going back to sleep.

I have tried this with DMT and it doesn't make the secondary effect "feel better" (still feel like a ghost) but I experience noticeably less time dilation and noticeably better memory of the events.


-In the future-
There is a new-ish class of sleep aids out there very few people know about. They are Orexin inhibitors. They give you narcolepsy, more or less lol. They increase the amount of REM sleep you have and reduce REM onset time. REM sleep is not lucidity, but I am curious enough to experiment with it if I ever get ahold of some. I have only observed it in sleep studies.

Trazodone is another drug I want to experiment with. I did a search, not many people have messed with it along with DMT, and fewer deliberately using small doses. Trazodone appears to occupy the 5HT2A receptors "antagonistically" well. It also affects a boat load of other things and really makes it hard to read some people's EEG when they are on it > : | so I am planning to use a small dose, maybe 20mg or some such, and fool around with that. See if low dose of trazodone side effects are better than the ghost effects, and if it will even stop the ghost effects.

EDIT: From rereading wikipedia Roughly half of brain 5-HT2A receptors are blocked by 1 mg of trazodone and essentially all 5-HT2A receptors are saturated at 10 mg of trazodone.

So I can try taking even less. Huzzah.
 
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I have not. Serequel has a laundry list of receptors that it affects measurably that it and most other anti psychotics are at the bottom of my list. The noted side effects compounding this. Trazodone has enough too to concern me, but most are weakly interactive. I imagine I will get to them eventually if I fail to find something that works great for me, though.

If anybody else has experience with these by all means share I'm also interested.
 
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