Recently swidvs found 25i-nbome properly applied to blotter, 1 was quite effective and absolutely requires sub-lingual dosing - effects begin 20-30 minutes in. Less scrupulous souls had been attempting to pass it off as Lucy - but you can not eat it and have an effect. It must be absorbed buchally or sublingually. It was found to be very enjoyable, a psychedelic MDMA more than a traditional psilocybin or LSD experience. One effect repeatedly noted was the inability to verbalize while under its effects, causing a case of derp-derp-derpa's instead of whatever you intended to try and explain. Overall, a very enjoyable "be here now" compound.
25c-nbome acetate was profoundly a different experience - it has been the most therapeutic empathogen with milder psychedlia ever encounted by swidvs. Of note, even without HPBCD complexing, the potentcy is remarkable and working with bulk is not to be done lightly - read up on stories of the good ole days before the Pickard silo and how anything touching crystal L or used while diluting to proper dosage levels was basically understood to be hazardously toxic. The one 'safety' aspect is due to the need for absorption through membranes, an accidental spill of concentrate will not send you over the rainbow for days - just a frustrating loss of a good compound instead of a serious incident of poisoning. That said - make no doubt about it, if improperly used, a concentrated solution can deliver several mg and was observed to cause intense disassociation, loss of coherence, a total loss of higher brain function resulting in almost reptilian habitual responses - and for a brief period, seizure. It is not something to be trifled with without research, respect and full disclosure to anyone who might be gifted it. Do not pretend it is LSD - it is most certainly NOT.
It IS however, a remarkable compound, of high potency in very low dosage and worthy of further experience.