Exp. Report New favorite substance for me: O-PCE

[Jorkest]

that sounds insane! im intrigued and terrified.. but speaking of bladder issues... I came up with a protocol for keeping your bladder healthy at least from ketamine.. but should work for most bladder inflammation issues. some of these things are likely specific to ketamine and im unsure how they would affect other substances. obviously do your own research on all these substances, make sure you arent allergic to any, start low and take care with every new substance you introduce into your body. one main point.. DRINK WATER.. this helps dilute your urine and keeps you flushing

- On Waking (Empty Stomach/Light Snack): Magnesium Glycinate 1500mg, Glucosamine sulfate 1000mg, NAC 500-900mg, EGCG 225mg, Quercetin 250mg, Chondroitin Sulfate 600mg, Hyaluronic Acid 100mg + 500mL water.

- +1 Hour (With/Without Small Snack): Zinc 15mg, L-Theanine 100mg + 500mL water. (timed to have them circulating in your blood before dosing the ketamine)

- +2 Hour (Ketamine + Breakfast): Aloe Vera 200x extract 200mg, Marshmallow 10x extract 300mg, Slippery Elm 400mg, D-Mannose 500mg + 500mL water.

- +5 Hours(Post ketamine): NAC 500mg, D-Mannose 500mg + 500mL water

- Dinner(At dinner): Fish Oil 1500mg, NAC 500mg, Quercetin 250mg, Chondroitin Sulfate 600mg, Hyaluronic Acid 100mg + 500mL water

Magnesium Glycinate, Zinc Picolinate, L-Theanine can enhance the effects of ketamine, reducing total dose needed. helpful when treating depression.

Glucosamine sulfate - the body converts glucosamine into GAGs(glycosaminoglycan, mucus-like layer on the inner surface of the bladder) and hyaluronic acid, fortifying the bladder's mucus-like barrier to prevent urine toxins from damaging underlying tissues, reduces inflammation, helps tissue repair

NAC - reduces oxidative stress and inflammation.. helps prevents bladder tissue fibrosis by inhibiting inflammatory pathways and promoting tissue repair.

EGCG - polyphenol from green tea, acts as a potent antioxidant and anti-fibrotic agent.. it helps protect against KIC(ketamine-induced cystitis) by reducing oxidative stress, interstitial fibrosis, and urothelial damage

Quercetin - a flavonoid with strong anti-inflammatory and mast cell-stabilizing properties, targets bladder inflammation common in IC(interstitial cystitis) like conditions...while direct KIC studies are limited, it's effective for IC symptoms (pain, urgency) via oral supplements, reducing histamine release and oxidative damage

Chondroitin sulfate - is a GAG component of the bladder's natural protective barrier, helping replenish the urothelial layer damaged by ketamine. It reduces inflammation and supports tissue repair

Hyaluronic acid - often paired with Chondroitin, is another key GAG that restores the bladder's lining, preventing urine penetration that exacerbates KIC inflammation and fibrosis

Aloe extract, Marshmallow, and Slippery Elm(likely overkill with all three but whatevs) - are demulcent herbs used to soothe irritated mucous membranes, including the bladder's urothelium... in KIC and interstitial cystitis/bladder pain syndrome, they help by forming a protective coating that mimics the damaged glycosaminoglycan (GAG) layer, reducing inflammation, irritation from urine toxins, and symptoms like pain, urgency, and frequency

D-Mannose - may ease urgency, frequency, and discomfort by modulating inflammation and supporting a healthier urinary environment, with some users reporting reduced flare-ups. D-Mannose binds to E. coli (the most common UTI-causing bacteria), preventing it from sticking to the bladder lining.. this flushes bacteria out during urination, reducing infection risk in damaged bladders prone to bacterial overgrowth due to ketamine's erosive effects(likely also unnecessary if your bladder is healthy, but doesn't hurt)

Fish Oil - beneficial for various inflammatory urologic conditions; may improve symptoms like pelvic pain and voiding dysfunction in IC


the main point for all this is to do everything possible to keep levels of these compounds up while your body metabolizes the ketamine. the halflife for ketamine is pretty short but its metabolites circulate for quite a bit longer and take longer to clear. thats why the constant NAC dosing and the doubling up on the Hyaluronic acid and Chondroitin morning and night.

i have been taking low dose(30-100mg sublingual) ketamine to help deal with some heavy grief that i just couldnt shake.. lots of random crying and feeling helpless.. coupled with some anxiety/depression. things had been going super great.. started to come out from under the cloud, was working through a lot... when after about a month of treatment i noticed i had some pelvic pain, was what i would consider mild but it was constant and really annoying. this was kind of distressing because i was just making some progress.. so i started researching and came up with this protocol. within 1 week(while still taking low dose ketamine) the pelvic pain completely went away(the bladder pain lasted about 2 weeks until i was a few days into this protocol). it's kind of a lot of work and not exactly cheap but it's a hell of a lot better than damaging your bladder.

this is also likely a bit overkill and i might make some adjustments if i feel like some stuff can be cut out.. but at this point im just happy i was able to address the bladder pain so quickly and reliably. also probably smart to get some urine test strips(these are plentiful and cheap) to check for blood. obviously if you start seeing some blood in your urine.. you should probably chill out on whatever youre taking.

 

[LoveBlanket]

I have quite an extensive experience with this dissociative, here are my commentaries, followed by a Trip report

O-PCE — I know this substance very well. I consider it the most dissociative of all dissociatives, stimulant and psychedelic at the same time, with effects that come in several phases. It’s my favorite disso — kind of the schizotypal, amphetamine-like version of Ketamine .

The hole is easy to reach, but incredibly chaotic and WTF because of the dopaminergic and noradrenergic stimulation, which gives you irresistible impulses to do random shit instead of lying down and enjoying the ride. With the amnesia on top of it, I’ve woken up from big O-PCE trips in incomprehensible situations, or with my apartment wrecked, or with friends telling me about things I supposedly did with absolutely no memory of them…

I can’t really help with dosages because of my tolerance. I’d say the substance is active between 3 and 30 mg in a single dose. Keep in mind that 30 mg with no tolerance sends you deep into the hole, and the risk of complete amnesia is very high.

But be careful — the “re-dose craving” is ultra strong, and the effects are cumulative. If you keep redosing, you’ll send yourself way farther and for much longer than expected.

Orally, the come-up is extremely long, especially if you swallow the crystals without crushing them first. For me it takes 2–3 hours to peak, and at least 10 hours to come down from medium doses.

Insufflated or plugged, it’s still fairly slow — like a solid 15 minutes before it starts. Be careful not to re-dose thinking it’s not working, lol.

The bodyload is very unique for me. It’s not the warm numbness of K or even 3-HO-PCP. I feel a strong electric/muscular tension that contrasts sharply with the dissociation. It feels like a heightened awareness of the body — as if the body were the last tangible thing that the dissociation hasn’t fully erased yet. You’re still numb, and at high doses I lose all motor control in a catatonic state, but at low to medium doses I’m actually stimulated but extremely clumsy.

The dissociation from O-PCE is deep. It’s not the hallucinatory sedation of ketamine. It’s more like a strange inversion where everything becomes unreal — except the “self.” But the “self” is reduced to a bare consciousness without body, without history, almost without content. This inner emptiness, this hyper-awareness of your own presence while everything else fades, can trigger intense anxiety, terror, and paranoia.

Not all at once — more like every layer of reality slowly peeling off, silently. Objects stop being solid; they turn into abstract shapes. Colors melt into each other and lose their saturation in a kind of waking dream. And you’re just there, the only tangible presence in a fading landscape. You catch yourself thinking: Maybe I’m the only real thing here… and even that, I'm not sure about.

At the core of such disorganization, the mind tends to fall into two modes:
grandiose hypomania or paranoia, panic, and unbearable feelings of losing control or losing yourself.

There is no time anymore. Only disconnected moments, suspended, flowing or freezing without logic. You no longer have a name, a history, or boundaries. You float in an almost empty reality, where everything — including you — feels artificial, transparent, temporary. And yet, inside this emptiness, there is something strangely peaceful: a naked, disembodied lucidity, a pure gaze on existence stripped of weight. It’s both terrifying and sublime — as if the whole world, including you, were a memory slowly fading away.

At high doses, the visuals are surprisingly intense and psychedelic for a disso — lots of fractals, shifting colors, abstract patterns like dancing shadows in the dark. But unlike a real psychedelic, it’s kind of like a cheap filter. Except in the hole, I find visuals to be more of a distraction, nothing truly deep or immersive.

The holes are absolutely crazy and indescribable. The most important thing is to lie down — if not, you’ll do stupid shit. But lying down with music gives me incredible mystical sensations, like literally feeling my body dissolve and my soul float away into the music.

At low doses it’s fun with people (if everyone is also on it). Past medium doses, it becomes pointless — communication collapses and turns into anxiety / a machine for misunderstandings.

Cannabis massively potentiates it.

I’ve combined it with LSD and Metocin. You have to be careful, because O-PCE is already very stimulating, but if the goal is to launch yourself into incomprehensible hyperspace, it works. It has given me Salvia-like experiences.

Also, the effect seems to have 2 or even 3 distinct phases:

• a slow, euphoric, foggy come-up
• a deep, almost catatonic dissociation
• then a dissociated stimulation with visuals that can last a very long time

Probably due to dopamine/serotonin/noradrenaline rebound from NMDA antagonism.

Sorry, I’m incapable of writing in a clean structure, but this is the best I can describe my experience with this molecule.

TRIP REPORT

O PCE X Cannabis : Boiling Brains

It’s noon, I just received the O-PCE. I’d been waiting for it — it had been a long time since I last revisited dissos. Today, I want to go far. Too far.
Fifteen milligrams weighed and swallowed, followed by a shower.

Stimulation begins within 30 minutes. My mood rises in a very artificial way, but the feeling stays cold. I go outside with my vape to burn off some of that energy.

The light blinds me, colored blotches appear as I feel more and more drunk. My neighborhood loses its familiar appearance; I’m suddenly trapped in a concrete complex. I have to escape, go back to safety. Confusion sets my soul on fire.

A vape and Pink Floyd’s Ummagumma. It’s magic — maybe even too much… And what if it could be even more?
Staggering around my dollhouse, I plug a little under 9 mg and keep vaping cannabis.

There’s a wardrobe in front of me and… there it is, melting into the impossible, in perpetual motion. I look around me — my entire apartment is melting. One by one, every object, like infinite candles, spreads across the floor without losing any substance.

I enter a completely liquid world as my stomach starts acting up. I feel full of water; all I can feel is a belly filled with water. My body is absent.
Every movement is pre-calculated and difficult. I settle for turning up the volume and turning on my vaporizer, watching my furniture play at being wax.
The effect is hypnotic and endless. Meanwhile, things like my door, normally vertical, appear duplicated horizontally.
It makes absolutely no sense.

Dirty body feeling, like being dipped in oil. I’m a bit bored for now — it’s pretty lame.

I take a dab. Blackout.

My phone rings. I remember that some friends were supposed to come today because they wanted to try O-PCE. Knowing friends are on their way reassures me a lot.
I’m a blank page. I’m nothing and no one anymore. I remember nothing except the O-PCE. That word echoes in my head, and the more it echoes, the more meaningless it becomes.

I feel absolutely nothing except a vague comfort. I feel like a baby, or some lower form of consciousness than a human.
Everything seems futuristic, as if I were a cosmonaut.
And when I get up to pee, I feel like I’m wearing their suit.
Staring at the irregularities on my walls, psychedelic fractals bloom in the void of my mind.

Electrical tension sensations, unpleasant overstimulation, following the sedative drunkenness.

The rare moments when I regain bodily awareness, I feel crushed under a stone, or like some viscous slug.
Diazepam. Dab. Blackout.

Cha and Ali are at my place, smoking joints and asking me how I’m doing.
I understand nothing; I have no idea how they got here. They remind me they arrived — it’s… quite shocking, this amnesia.
Little by little, I realize they’re my friends and that they want some PCE.
Everything seems both logical and on the verge of implosion, like in a dream where nothing makes sense.

Cha and Ali don’t believe me when I lay out a line for them.
They love K, but this? You can trip from this tiny shitty line?
I reassure them they can trust me. Used to ketamine doses, twenty minutes later they’re blown away.

We talk, share joints, everything feels smooth and normal, but it makes absolutely no sense.
Each of us is having our own conversation and answering things that have nothing to do with one another, thinking it’s normal, then realizing the absurdity and bursting into laughter.

As Cha and I are too far gone to grasp what’s happening, Ali grabs one of my LSD vials and takes an unknown amount — but clearly a lot.
We only realize what she did afterward — her too.
I think we were just talking about L…
It’s one example of the dangerous disinhibition arylcyclohexylamines can cause.

Ali spends the rest of the evening completely wrecked, looping on whether she took LSD or not.
We tell her she did, but everything feels like a dream…
Cha and I aren’t sure what’s real and what’s imagined because of the insane level of memory loss and suggestibility we’re under.

Ali showers, describing universes in every drop of water. It looked intense — she came back from it in a trance.
She lies down on the floor and suggests going out. Cha and I each plug 15 mg more.
I start feeling tense and overheating. Going outside feels amazing, even in night clothes.
The whole time, we don’t know what’s real or imaginary. We get impressions of telepathy; our thoughts seem to manifest as visions or false memories, which is very disturbing.

Near my building there’s a hidden spot under the trees, with a strange stone table and misshapen benches. Very trippy.
We had made a pentagram there previously with branches and salt.
We pack bowls; the place feels literally mystical in this state.
For nearly two hours, in the dark, we chain bongs and marvel at the rock and the spiderwebs. It’s like looking at another planet. And it doesn’t even look like we’re looking at something up close — more like a landscape on Saturn. Distances and sizes make no sense.
Almost no words are exchanged during those two hours, but we feel a deep sense of communion… telepathic?

There’s a very sacred, prehistoric vibe to what’s happening. I don’t know what it is, but the moment touches something transcendent.
We are three, but we are alone. Yet we are united.
And more than anything, we’re in the void of the present moment, in its crushing and elusive intensity.

Elusive. Such is the night. Such is life.

We’re dancing around the borders of psychosis, and we know it. It’s one of the few things we verbalize to reassure ourselves. We’re aware of it — and that’s what we enjoy.
After talking about it a dozen times, we decide to get up and head back to my place. Cha falls while standing up; we all burst out laughing.
From the outside, we’re a bunch of drunks on ether.
We really think we’re cosmonauts.

I take 15 mg more orally; they do too. Then the LSD becomes too intense for Ali, so she decides to go home with Cha and texts that they arrived safely.

Meanwhile, I put on Éliane Radigue’s music, take a dab, fill my vape, turn off the lights, and prepare to hole.

Indescribable annihilation of Being, while having a hyper-consciousness of intensity and the T-Zone, at once infinite, already finished here, but over there.
I’m dying of heat under my blanket, and the musical tension sends me boiling.
A long abstract visionary phase follows, during which I feel myself vaporize into the music, merging with it, senseless rotating forms.
I feel like I’m seeing the underside of reality, that vision — like my other senses — is nothing but a matter of frequencies unreadable to the human mind.
I feel limited by my humanity. I feel like ancient, extraterrestrial knowledge is about to be revealed to me, but I’m unable to grasp it.

After that, I fall into a nasty comatose sleep for about 10 hours, wake up overstimulated, give the rest of the O-PCE to trusted friends, and promise myself never to repeat the experience even though it was incredible.


Manic bursts, tachycardia
Everything tossed around, bad trip, vomit in the taxi
Occult knowledge taught in silence
My soul, my humanity I transcended
Brain and nostrils clogged with angel dust
And the walls of reality crumble
like old hash
Space twists inside its own dimensions
Child-like 2D drawings with crooked shapes
I shed the ridiculous shell that is my friend
And drag around a numb carcass
My steps, the dance of an undefined robot

That's good music to listen too while on O PCE

---

 

[JungleGhost]

Need 2 try. My symtoms are out of control.

 

[TheGreenPhantom]

@LoveBlanket Thanks for the report. It was an enjoyable read. I lived vicariously through your words. But I think this is something I'd pass on.

 

[Pandora]

I wish I could get some.

 

[metatronn*]

As you all know, besides DMT, Moxy has been my favorite substance for a long time, even much so that I dare to say I am probably the person that has the most experience with Moxy on this planet, and who knows the whole universe.


That aside, I found another substance that took me further then I ever could imagine before, even with DMT in mind: O-PCE.


First note of warning though: You have to be VERY carefully with dosing this substance, this since dosing too high can quickly turn into a mania-like journey, where you might come into a situation where you hurt yourself or others by accident, you do not not know anymore what reality is, and it's not like a delirium, just that the substance removes you from this universe and takes you to another one where you have NO clue what is happening and how to make sense of it anymore.

There is a fatality case with this substance! Though never on it's own, always taken together with multiple other substances. Any substance that can help cause serotonine syndrome is probably VERY dangerous with this substance!

A Fatal Case Involving N-Ethyldeschloroketamine (2-Oxo-PCE) and Venlafaxine

Cluster of acute poisonings associated with an emerging ketamine analogue, 2-oxo-PCE (no deaths, though 56 total cases!)

A combined toxicokinetic and metabolic approach to investigate deschloro-N-ethylketamine exposure in a multidrug user (no deaths either, just that O-PCE was also used in the multidrug user, with some interesting information about possible health implications)


Now back to my new favorite substance: O-PCE.

It's a dissociative, that unlike any other dissociative I've ever taken, has extremely profound psychedelics effects, it goes FAR beyond the well known K-hole, and like I said before: it removed you from this universe to propel you into a new one, and dear me, they is just fascinating! No entities, though very visual and with a lot of structures in all sorts and sizes.

I have been swirled into a pink stormy ocean, lifted into a room that looked like I just stepped out of a simulation ("welcome back Traveler, we hope you liked our total immersion VR"), and all the while with my rational mind being unable to even try to make sense of any of it.

Also, unlike many psychedelics, it has no fear for me when I take a dose high enough to be lifted into the O-PCE reality-space, one 30mg capsule taken orally is for me the usual dose, topped up when it starts with one or two extra 10mg capsules, depending on how I feel. It's a pretty smooth ride that keeps you being wondered about what you are observing. I have tried opening my eyes and closing my eyes in a very dark room, and only when the dose is not high enough and when I switched on a tiny light could I make a reality check to see if I was still in my bed at my own home.


It only got very scared once, where I became very reckless and dosed about 4 times the normal dose, just to see where that would bring me. With this high dose you have to understand that this also means I have tried the triple dose before, and unlike the quattro one, that triple one was a very interesting ride! With 4 times the normal dosis though I got into some sort of mania, not a delirium per se, where I was not sure if I could have overdosed or not, I could not rationalize what I had done and screamed for my wife to please help me, even though I knew that no people had died from taking O-PCE alone, I still did not want to be the first one.

After drinking a bit of water, all lights went out for me and I dropped completely unconsciously, that was the moment my wife called the emergency services, they helped her really well, and an ambulance was called. I do not recall the ambulance coming over, neither the ride to the hospital, and neither the handing over in the hospital, my wife just said they were all VERY kind people, and the medics told right away that no police would be involved since I was non aggressive (duh, I was totally knocked out) and in NL it just does not make sense to call the police if there is no need for it, they have many better things to do.

The first time I woke up was in the hospital, and when looking around I was extremely confused, since there was simply NOBODY around, all quiet, you could not even hear a whisper, and then when I looked up I saw some beautifully arranged bright lights in a large square, all clean and smooth, and that is where I thought that I might have woken up from being in a simulator ("welcome back Trav!"), it just made total sense to my non-functional frontal lobes.

Quickly after that a complete team of medical personnel arrived, and after that they took a blood sample to check what substance I could have taken, and send that to the lab. In the meantime, my wife told the medical staff about my work with entheogens, the DMT-Nexus, the science and the harm reductions responsibilities coming with it, and the reason why I take this journeys: so I can provide you with information on what to do and especially what NOT to do (yeah, great job Trav!), This however made a profound change in the mindset of the leading doctor, and he strictly ordered that I would be treated with utmost respect, and that they had to be very gentle with me, and keep score of lots of data to work with me later on.

After that came the full IC care treatment, heart electrodes, infusion, oxygen meter, the whole technical suite and.... including putting me in my own private IC room!

In that room is where I woke up a second time and it was absolutely unreal, I was still tripping sooooooo hard, and there was this constant fresh airstream, a bed that was nice and with the way they can move each part of the mattress for your comfort, they set it exactly right for me, they attached an urinating tube as well, so no worries in that department, and I was being monitored 24/7 for my safety and welbeing.

Now one special request: Please, like REALLY please, NEVER tell this to me wife, since this was very traumatic to her!

However, for me, this was THE MOST ULTIMATE JOURNEY SPOT I have ever been in to trip on any substance, I felt safe, all was kept in just the right temperature for me, no sweaty stuff due to that extremely sufficient overpressure air circulation, so also no outside allergies possible, I could order drinks with just a click on the attention button for a nurse to show up, and for me it was just heaven since I was still tripping the literal balls to the walls with no end in sight, while feeling extremely happy, comfortable, safe and attended too.

I took that 4 times the normal dose around 3:00AM in the night from Saturday to Sunday, and they stated I would be released Sunday at 19:00 (7PM), when I entered the IC it must have been 10:00AM or so.

My brother also came to visit me, To support me and to help me getting home after I would be released (thank you so much for this all my brother!). Between 13:00 (1PM) and 19:00 (7PM) my brother and my wife went back to our home, to hike a bit, talk things over and have a nice hike to clean up their heads. So for about 6 hours I could slowly come down from my extreme journey, in that in the most pleasant way, so for those 6 hours I enjoyed every moment of it, I had a nice meal, once in a while another solid fruit/water drink, and in between when I was a bit more approachable, I had essentially some very interesting discussions with the hospital staff.

Around 19:00 (7PM), my wife and brother showed up again, I wobbled out of bed (still a bit in the disso robot-walk fashion), dressed up and checked out, after which my brother drove me home and I wend straight to bed. I recall while reading my eReader in bed, that vivid OEV's would still spontaneously pop-up next to my eReader, that is how heavy the dose was that I had taken.


So, that was the 'harsh' part of it, in the hopes of making sure sure you will all be relatively careful with a substance like this.

Once I learned to better dose, like preparing all capsules beforehand: 1 with 30mg, and two others with 10mg when I would like to go deeper. That way, without tolerance, I can go very deep, without going that silly 4 times the 30mg dose, traumatizing people around me and putting a non-essential burden on the health-care system.

Since then I have moved on with further discovering the O-PCE reality-space, and with that exploration two special things really stuck out after a while, two things that I never had on any other of the 80+ substance I ever took:

1. Total recall of ANY music I ever heard, I could play it in my head like just from a radio, mix it with any other music I knew, and just generally just play with it like I was a master mixer in some studio. The sound quality was just gorgeous.
   
   
2. After hours of tripping, I could do that same thing with visuals! I could just visualize anything I was creative enough to imagine, and it was just there as in real life, moving and behaving just like the real thing, and not just a visual, no, a true real life hallucination as if it was there, no difference as to how I would observe that same thing in real life. For me it's something amazing to be able to do, I never could have imagined this was even a possibity!

So, after this long piece of text, you might get a clue as to why this substance is so interesting for me. The biggest drawback is that if you take as lot, like 60mg total, the next day you are pretty fuzzy in your head, you cannot remember much and forget a lot of simple things, the other thing is that you do a bit of the drunk duck waggling the rest of your waking day. The day after that however, it's completely over, and the afterglow of the substance is lingering for quite as few days.

Another thing that I must warn you for is that it has seemingly the same effects on your bladder as ketamine, and even though you take a much lower dose than you would normally take for something like ketamine to K-hole, it's still more than nothing. And in the hospital they (and I) could easily see the dark "flocks" in my urine samples. I am not sure how harmful they are, thankfully I have no bladder issues, but it can be that you might be more sensitive, so please be careful and if needed let your bladder get monitored regularly.

So now I have three favorite substances:
1. DMT
2. Moxy
3. O-PCE

With my vivid story posted here I hope you all got some solid information out of this trip report, and I'll be happy to answer any genuine question. I will be exploring this substance for a loooooong time to come, and this time safely, I have learned to navigate O-PCE reality-space.


Kind regards,

The Traveler

I've had that same experience on dmt with the part you were talking about how you could picture anything perfectly. For me it was like I had smoked a very tiny amount of dmt but then for like the rest of that day my ability to picture things was incredible. Almost as if my brain was a 3d modeling software and I was a pro at using it. Like the most intricate objects animals or anything I could picture it and move it around a distort it in any way that I wanted while having full detailed visual in my head. The thing is is I didn't have to close my eyes I still be looking at real things but at the same time doing all that photographic visualizing stuff