I guess I'm gonna take the other stance on this one. I don't believe that it's necessary to take other drugs to take DMT. They really don't have much to do with each other. DMT's not like most other drug experiences (including the low-dose long-term psychedelic ones that most people who have moderate experience with drugs tend to have). I've administered DMT to people who haven't touched anything else before, and it's gone great each time. I don't personally believe it's a pre-requisite. It's short-acting, so if things do go sour, it won't be for long, and I personally find IME DMT to be more forgiving and embracing than other drugs/psychedelics.