King Tryptamine
Esteemed member
Introduction:
The beta-carboline constituents of Peganum harmala, Harmine, Harmaline and harmalol are well known to be inhibitors of a variety of endogenous enzymes such as; monoamine oxidase A and acetylcholinestrase. This will be a short review discussing the medical applications of another lesser known enzyme these alkaloids have been found to inhibit, the CYP1A1 protein.
Inhibition of CYP1A1:
The CYP1A1 enzyme is responsible for activating environmental pro-carcinogens such as the polycyclic aromatic hydrocarbons found in automobile exhausts and other self administered compounds, E.g. tobacco smoke (tobacco specific nitrosamines) via metabolism into carcinogenic, DNA reactive species causing unhealthy mutations to occur within these proteins. Now the alkaloids harmaline and harmalol present in P.harmala have been found to inhibit these CYP1A1 enzymes in an analogous manner to monoamine oxidase A, thereby reducing its effectiveness to metabolize pro-carcinogenic compounds into carcinogenic ones, in turn reducing the frequency or likelihood of these species reacting with DNA causing cancerous mutations to occur. A possible medical application to exploit the anti-cancer effect of these compounds would be say... giving them to a person working in pollutive work space such as a BBQ or a chemist working with volatiles, just a suggestion. Anyway thought you guys may benefit from a new way to use harmalas other than potentiating DMT :thumb_up:
Reference - Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms
The beta-carboline constituents of Peganum harmala, Harmine, Harmaline and harmalol are well known to be inhibitors of a variety of endogenous enzymes such as; monoamine oxidase A and acetylcholinestrase. This will be a short review discussing the medical applications of another lesser known enzyme these alkaloids have been found to inhibit, the CYP1A1 protein.
Inhibition of CYP1A1:
The CYP1A1 enzyme is responsible for activating environmental pro-carcinogens such as the polycyclic aromatic hydrocarbons found in automobile exhausts and other self administered compounds, E.g. tobacco smoke (tobacco specific nitrosamines) via metabolism into carcinogenic, DNA reactive species causing unhealthy mutations to occur within these proteins. Now the alkaloids harmaline and harmalol present in P.harmala have been found to inhibit these CYP1A1 enzymes in an analogous manner to monoamine oxidase A, thereby reducing its effectiveness to metabolize pro-carcinogenic compounds into carcinogenic ones, in turn reducing the frequency or likelihood of these species reacting with DNA causing cancerous mutations to occur. A possible medical application to exploit the anti-cancer effect of these compounds would be say... giving them to a person working in pollutive work space such as a BBQ or a chemist working with volatiles, just a suggestion. Anyway thought you guys may benefit from a new way to use harmalas other than potentiating DMT :thumb_up:
Reference - Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms
