please somebody help me. brain zaps

[Sandgrease]

I took various SSRIs for about 7 years and I used to get brain zaps when I was weaning off them. I believe it's serotonin related. I also get them sometimes om tryptamines.

 

[Intezam]

Can you explain the interaction here? I'm not finding anything that says this would be dangerous. The few times I've tried it it's been a fine combination. I never eat the seeds though, just chew on them, suck for a while, and spit.

Both increase blood pressure and the rate at which the heart pumps, and combined it could be dangerous.Perhaps there is less danger when whole rue seeds or rue tea is taken. Possibly the harmane/̶h̶̶a̶̶r̶̶m̶̶a̶̶l̶̶o̶̶l̶/Vasicine has a cardiac–depressant effect and also act as a vasodilator? These are typically not present in the extracted harmalas. But anyway, we don't know the exact interaction here.

 

[slewb]

Intezam - I'm not sure where you are reading that harmala alkaloids increase heart rate and blood pressure. Research indicates the opposite.

from Comparative study on the vasorelaxant effects of three harmala alkaloids in vitro - PubMed

Three psychological active principles from the seeds of Peganum harmala L., harmine, harmaline and harmalol, showed vasorelaxant activities in isolated rat thoracic aorta preparations precontracted by phenylephrine or KCl with rank order of relaxation potency of harmine > harmaline > harmalol.

from Cardiovascular actions of three harmala alkaloids: harmine, harmaline, and harmalol - PubMed

Each of three harmala alkaloids, harmine, harmaline, and harmalol, decreased heart rate and increased pulse pressure, peak aortic flow, and myocardial contractile force in intact normotensive anesthetized dogs. Harmine reduced systemic arterial blood pressure and total peripheral vascular resistance; harmaline-evoked decreases were frequently followed by a secondary increase; and the effects of harmalol on these two parameters were inconsistent.

In my own experience - daily harmala use has brought my blood pressure down to healthy levels. Next time you dose try checking your own heart rate and blood pressure, see what happens.