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Potentially New Study on Anesthesia-like DMT Administration

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Those are all nice examples Nathanial even though most of them aren't mentioning of psychoactive drugs that I'm talking about, an exception being David Nutt and his research (Do you mean psilocybe and Default-mode-network, if it is, that is terrific research). I immediately thought of another David and his research and to be honest and one can not be without the other. The science needs the spirit and the spirit needs science y'knoo

But it's all about intention

All-in-all the psychedelic drug research is a little slow for my taste. What good is DMT-research going to do for me as an example. By the time I'm old there going to find out that there's elves in there.. What I meant is if you really want to find out what DMT is doing psychologically you could do trials with a Tibetan Monk if you really want to find out things.

Right now, I am positive that these fellas are just killing a curiosity with this research and there's nothing groundbreaking that's going to arise out of this. Strassman was kind of the same thing, don't you think?

I am a little bit tired (1 AM) so if my post seems a little bit sporadic, here's why! :D

From reading ur posts around here you seem well-versed in the subject, do you have professional expertise in these fields or are u just a well-informed citizen. If so, in what field are you doing work? I wanted to ask
 
Nathaniel.dread, I'm right there with you on your points..

Here is my point of view... I look at the risk versus reward. So what are the risks? Well, DMT is already at the top of the list of illegal drugs so it's unlikely that it will be any more controlled as of the result of a poorly conducted study. There are risks to the individuals involved but similar risks exist in any study. This is why participants must come freely and be properly informed of all potential risks.

What are the rewards? They could be infinite because this is a molecule we simply do not understand. Or the rewards could be negligible. At the very least, the rewards could simply be people asking more questions and increasing awareness.

I figured there would be dissenting opinions here and I understand to a degree those opinions, but I think we ought to realize that despite our many experiences and personal research, we do not understand what is really happening when a human brain receives DMT. We all have our own ideas but no one can back it up because the research is not there.

Now there will always be risks versus rewards with any scientific study, but I believe the potential rewards greatly outweighs the risks in this case. Further, I'm sure many here have benefited from the questions asked by the movers and shakers who have covered psychedelics
... McKenna, Leary, Strassman, Watts, etc... If it wasn't for Strassman's study, I probably wouldn't have learned of DMT and DMT has lead me to some very positive realizations and changes in my life. I'm sure this has been the case wit many others.

I believe that the way we evolve as a species is to keep asking questions and looking closer for answers. Even if our questions lead to further questions, we move forward. With the right intentions, our curiosity may be one of the most important aspects of our species. And these individuals leading the way, boldly in these studies seem to have the right intentions.
 
I am not familiar with how research papers function but I would like to ask what is this paper even good for apart from our solidarity?

In other words, is there someone who will read this and find it useful by way of further development and/or trial?

Or is it just a paper that floats about that stubborn-minded scientists look at and think "what's all this psychedelic nonsense? get rid of it."...

I am just curious to know who is on the receiving end apart from us?
 
fathomlessness said:
I am not familiar with how research papers function but I would like to ask what is this paper even good for apart from our solidarity?

In other words, is there someone who will read this and find it useful by way of further development and/or trial?

Or is it just a paper that floats about that stubborn-minded scientists look at and think "what's all this psychedelic nonsense? get rid of it."...

I am just curious to know who is on the receiving end apart from us?
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In the world of science, it's hard for an idea to gain traction without being first published in a peer-reviewed journal, where it can then be later cited.

As an example, before the Imperial College crew could do their ground-breaking psilocybin studies, both they, and others, put out a vareity of more theoretical pieces that don't immediately provide useful data, but help build a strong foundation from which to pitch future research.

Now, it's complicated because 1) Fronteirs exists in kind of a weird space, where it is peer-reviewed, but often seen as a little more 'fringe,' and doesn't fit in quite as well with the established cannon of journals, and 2) Strassman is kind of a loon so who knows what he's up to.

Infectedstyle: I was responding mostly to this part of your post, which did not seem psychedelic specific (the "all other hard drugs" thing):
We have applied this method to all other significant hard drugs and have reached nothing. People still are addicted and abuse coke left and right. The only real outcome of these studies has been the synthesis of anti-medicines and harm reduction drugs.
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Blessings
~ND
 
Artemis said:
Anesthesia-like administration meaning it is similar to the administration of anesthesia. I can see how it is somewhat confusing but that's what the original paper is linked :)

I see the side of skeptics on this type of research but I lean towards the supporters. Despite our many experiences and knowledge on DMT, no one really knows what is truly happening. Because of strict scheduling of these plant based entheogens, important scientific research has been very suppressed. Entheogens could be the link to bring our species to come together and move forward. I believe it is critical to research as a possibility. I am also one to believe, like Gallimore, Strassman, and Hancock that these entheogens are not simply hallucinations conjured up by our brain with no deeper meaning, but tools that allow our consciousness to move between planes of reality, potentially alternate universes.

There is another paper by Gallimore that explores Simulation Theory and how DMT may relate to it. He explains how the DMT molecule shows up all over nature almost as if it was by design. A simple molecule that is so easily accepted through the blood-brain barrier has been hiding in plain sight. Check out this paper too.

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Despite strict scheduling we must keep in mind that:
DMT is the only psychedelic tryptamine that has recently been taken through the Kafkaesque processes for approval for human studies (via the FDA, the DEA, and the other Health agencies of the Government) and is one of the few Schedule I drug that is being looked at clinically in this country today. It has been studied in New Mexico, in Albuquerque. The first published results of this study show a smooth grading of subjective effects as a function of injected dose. The lowest dose (i.v.) was 0.05 mg/Kg, about 4 milligrams, and it could not be distinguished from placebo. At 8 milligrams, there were the physical effects without the mental. At 15 milligrams (the threshold psychedelic dose) nearly all subjects had visual hallucinations, but the auditory changes were rare. At 30 milligrams, the effects were overwhelming both in speed and in intensity. The rush, the freight-train as several subjects call it, was well underway well before the 45 second infusion was complete. A study of repeated administrations of dosages of 16 mg i.v., at half-hour intervals, were made to explore the possible development of tolerance, showed that there was none observed. -shulgin ; TIHKAL
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The more reasons to research, the better in my eyes....

I remember reading through a human DPT study where the DPT was administered in this manner...

I'll try to find it...

-eg
 
fathomlessness said:
I am not familiar with how research papers function but I would like to ask what is this paper even good for apart from our solidarity?

In other words, is there someone who will read this and find it useful by way of further development and/or trial?

Or is it just a paper that floats about that stubborn-minded scientists look at and think "what's all this psychedelic nonsense? get rid of it."...

I am just curious to know who is on the receiving end apart from us?
Click to expand...

I did the pharmacokinetic analysis because I had a hunch that DMT's PK profile was probably similar to many general anaesthetics - I brought Strassman into the fold since he had the original blood data from his 90s study. The point of the article was really as a proof-of-principle that the target-controlled continuous IV technology would work with DMT. and to explore some of the potential applications of such a technology. Of course, ideally, in the future someone (me? Strassman? not sure yet) could implement the model in a human study (actually, the Imperial team were going to do so for their new (and ongoing) DMT study, but opted for bolus at the last minute since it was felt infusion was a step too far for a first study). It's a first step basically :)
 
Nathanial.Dread said:
1) Fronteirs exists in kind of a weird space, where it is peer-reviewed, but often seen as a little more 'fringe,' and doesn't fit in quite as well with the established cannon of journals, and 2) Strassman is kind of a loon so who knows what he's up to.
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1. Frontiers isn't "fringe" at all. Yes it's newer than the "canon" (largely locked behind paywalls), but it's very mainstream now, with journals from a huge range of fields, from psychiatry to engineering to psychology - none of them fringe. It was founded by Henry Markram, who can hardly be called fringe haha. However, we chose Frontiers since the Imperial team (and myself, Ede Frecska, and others) have published on psychedelics there before. They are pretty open to this kind of work and a nice journal to work with....

Actually, Rick, Ede Frecska, and myself are currently accepting submissions for a special Frontiers Research Topic devoted to psychedelics (to be published as a free ebook next year). We already have a good number of high profile psychedelic researchers on board, but anyone can submit a paper (if any scientific Nexians are interested!):

Psychedelic Drug Research in the 21st Century

Basic science research with psychedelic drugs continued relatively unabated after the cessation of clinical work with these compounds in 1970. Studies with the “classic psychedelics”, whose most well-known representative is LSD, have been responsible for fundamental discoveries in...
journal.frontiersin.org journal.frontiersin.org

Anyway, there's certainly nothing "fringe" or controversial about our article - it's mainly a mathematical model and simulation based on experimental (blood sampling) data. It's about as non-controversial as you can get really. The only potentially controversial or fringe element is introduced when one thinks about how the model might be applied in humans and for what purpose. But we only give a few ideas in the paper. The bulk of the paper is development of the mathematical model and analysis of the simulations - hardly fringe stuff!

2. Whatever your opinions on Strassman's "other" work of late, I think it unfair and somewhat disrespectful to call him a loon. Just remember who it was who had the balls and tenacity to execute that original DMT study in the 90s and how valuable it was, not only for DMT research, but for blazing the trail for much of the work on psychedelics that's followed since then. Strassman still advises on a very large number of psychedelic studies (including those of the Imperial team) and continues to be invaluable in this regard.

Ahoy! :d
 
Thank you for your input laughingcat! Your contributions to the research of this molecule are very appreciated! I'm curious to hear your thoughts on where you think this research may lead us. I personally believe DMT could have major positive implications for humanity.
 
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