https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00276
So in this paper that does have conflict of interest due to being tied to a patent but has references to some of the claims. So it shares a number of agonists to TRPV1 which when taken act synergistic to 5-HT2A receptor. It limits to the effects of reducing inflammation and enhancing mental and physical health but doesn't make since it wouldn't also enhance the psychedelic effects.With mescaline this would play a larger factor in theory since mescaline main receptor is 5-HT2A where dmt and lsd and i believe mushrooms the main receptors are 1a and 3a. With cielo we already have acidic salt HOWEVER all the salt forms are acidic so doesn't make sense only a partial effect? The amount of 1.2-1.5g citric acid would be the amount to fully activate the receptor based on a paper testing on rats also that value would make sense based on the amount of lemon juice used in lemon tek comes to compatible amount.
You would predose, take with or take after your dosing of the compound you want to enhance. The paper mentioned a few TRPV1 agonists like citric acid which is around 1.2-1.5g to activate, black pepper around 70mg of piperine, cuminan, capsaicin, and a few others... One thing that adds to this idea is the fact that some peyote ceremonies are done in sweat lounges which temperatures over 42-43C also activate the receptor
A very hot shower, or sauna may replicate effects.
The contradicting information I've found is in relation to capsaicin. In trouts notes on ayahuasca additives there is a mention of the capsaicin chinese and the wives of shaman use it to remove from red caapi intoxication while the following citation doesn't have any notations indicating its use as an additive. MAYBE the maoi is dulled with the capsaicin or something IDK. This was on my list of things to try in the future.
The paper has a link to the patent which is VERY long but near the bottom they do provide some values and recipes as well.
This is a safer alternative to taking these plants with MAOI and also will provide the additional benefit these are cheap and readily available alternatives and much easier than maoi sources. You can mix a few different sources that may have added benefits like ginger to aid in nausea PLUS is an agonist so works the same test this by predosing or dosing during the experience 1g of citirc acid or other agonists mentioned in the paper
This is also the likely reasoning for lemon tek since just acidic conditions without heating won't convert the psilocybin. But the citric acid would activate the TRPV1 agonism enhancing the 5-HT2A activity.
and would be worthwhile to test, I think especially the combination of citric acid and mescaline since the strong 5-HT2A affinity of mescaline.
