i wrote this up for another thread but thought it should be posted here as well.
I came up with a protocol for keeping your bladder healthy at least from ketamine.. but should work for most bladder inflammation issues. some of these things are likely specific to ketamine and im unsure how they would affect other substances. obviously do your own research on all these substances, make sure you arent allergic to any, start low and take care with every new substance you introduce into your body. one main point.. DRINK WATER.. this helps dilute your urine and keeps you flushing
- On Waking (Empty Stomach/Light Snack): Magnesium Glycinate 1500mg, Glucosamine sulfate 1000mg, NAC 500-900mg, EGCG 225mg, Quercetin 250mg, Chondroitin Sulfate 600mg, Hyaluronic Acid 100mg + 500mL water.
- +1 Hour (With/Without Small Snack): Zinc 15mg, L-Theanine 100mg + 500mL water. (timed to have them circulating in your blood before dosing the ketamine)
- +2 Hour (Ketamine + Breakfast): Aloe Vera 200x extract 200mg, Marshmallow 10x extract 300mg, Slippery Elm 400mg, D-Mannose 500mg + 500mL water.
- +5 Hours(Post ketamine): NAC 500mg, D-Mannose 500mg + 500mL water
- Dinner(At dinner): Fish Oil 1500mg, NAC 500mg, Quercetin 250mg, Chondroitin Sulfate 600mg, Hyaluronic Acid 100mg + 500mL water
Magnesium Glycinate, Zinc Picolinate, L-Theanine can enhance the effects of ketamine, reducing total dose needed. helpful when treating depression.
Glucosamine sulfate - the body converts glucosamine into GAGs(glycosaminoglycan, mucus-like layer on the inner surface of the bladder) and hyaluronic acid, fortifying the bladder's mucus-like barrier to prevent urine toxins from damaging underlying tissues, reduces inflammation, helps tissue repair
NAC - reduces oxidative stress and inflammation.. helps prevents bladder tissue fibrosis by inhibiting inflammatory pathways and promoting tissue repair.
EGCG - (keep doses below 300mg a day for liver health)polyphenol from green tea, acts as a potent antioxidant and anti-fibrotic agent.. it helps protect against KIC(ketamine-induced cystitis) by reducing oxidative stress, interstitial fibrosis, and urothelial damage
Quercetin - a flavonoid with strong anti-inflammatory and mast cell-stabilizing properties, targets bladder inflammation common in IC(interstitial cystitis) like conditions...while direct KIC studies are limited, it's effective for IC symptoms (pain, urgency) via oral supplements, reducing histamine release and oxidative damage
Chondroitin sulfate - is a GAG component of the bladder's natural protective barrier, helping replenish the urothelial layer damaged by ketamine. It reduces inflammation and supports tissue repair
Hyaluronic acid - often paired with Chondroitin, is another key GAG that restores the bladder's lining, preventing urine penetration that exacerbates KIC inflammation and fibrosis
Aloe extract, Marshmallow, and Slippery Elm(likely overkill with all three but whatevs) - are demulcent herbs used to soothe irritated mucous membranes, including the bladder's urothelium... in KIC and interstitial cystitis/bladder pain syndrome, they help by forming a protective coating that mimics the damaged glycosaminoglycan (GAG) layer, reducing inflammation, irritation from urine toxins, and symptoms like pain, urgency, and frequency
D-Mannose - may ease urgency, frequency, and discomfort by modulating inflammation and supporting a healthier urinary environment, with some users reporting reduced flare-ups. D-Mannose binds to E. coli (the most common UTI-causing bacteria), preventing it from sticking to the bladder lining.. this flushes bacteria out during urination, reducing infection risk in damaged bladders prone to bacterial overgrowth due to ketamine's erosive effects(likely also unnecessary if your bladder is healthy, but doesn't hurt)
Fish Oil - beneficial for various inflammatory urologic conditions; may improve symptoms like pelvic pain and voiding dysfunction in IC
the main point for all this is to do everything possible to keep levels of these compounds up while your body metabolizes the ketamine. the halflife for ketamine is pretty short but its metabolites circulate for quite a bit longer and take longer to clear. thats why the constant NAC dosing and the doubling up on the Hyaluronic acid and Chondroitin morning and night.
i have been taking low dose(30-100mg sublingual) ketamine to help deal with some heavy grief that i just couldnt shake.. lots of random crying and feeling helpless.. coupled with some anxiety/depression. things had been going super great.. started to come out from under the cloud, was working through a lot... when after about a month of treatment i noticed i had some pelvic pain, was what i would consider mild but it was constant and really annoying. this was kind of distressing because i was just making some progress.. so i started researching and came up with this protocol. within 1 week(while still taking low dose ketamine) the pelvic pain completely went away(the bladder pain lasted about 2 weeks until i was a few days into this protocol). it's kind of a lot of work and not exactly cheap but it's a hell of a lot better than damaging your bladder.
this is also likely a bit overkill and i might make some adjustments if i feel like some stuff can be cut out.. but at this point im just happy i was able to address the bladder pain so quickly and reliably. also probably smart to get some urine test strips(these are plentiful and cheap) to check for blood. obviously if you start seeing some blood in your urine.. you should probably chill out on whatever youre taking.
and finally the best advice is.. if you notice any bladder/kidney issues.. you should just stop taking ketamine. though most cases of severe ketamine induced cystitis are from abusing ketamine for long periods of time.. with a lifetime limit of 200-300 grams for most people.
I came up with a protocol for keeping your bladder healthy at least from ketamine.. but should work for most bladder inflammation issues. some of these things are likely specific to ketamine and im unsure how they would affect other substances. obviously do your own research on all these substances, make sure you arent allergic to any, start low and take care with every new substance you introduce into your body. one main point.. DRINK WATER.. this helps dilute your urine and keeps you flushing
- On Waking (Empty Stomach/Light Snack): Magnesium Glycinate 1500mg, Glucosamine sulfate 1000mg, NAC 500-900mg, EGCG 225mg, Quercetin 250mg, Chondroitin Sulfate 600mg, Hyaluronic Acid 100mg + 500mL water.
- +1 Hour (With/Without Small Snack): Zinc 15mg, L-Theanine 100mg + 500mL water. (timed to have them circulating in your blood before dosing the ketamine)
- +2 Hour (Ketamine + Breakfast): Aloe Vera 200x extract 200mg, Marshmallow 10x extract 300mg, Slippery Elm 400mg, D-Mannose 500mg + 500mL water.
- +5 Hours(Post ketamine): NAC 500mg, D-Mannose 500mg + 500mL water
- Dinner(At dinner): Fish Oil 1500mg, NAC 500mg, Quercetin 250mg, Chondroitin Sulfate 600mg, Hyaluronic Acid 100mg + 500mL water
Magnesium Glycinate, Zinc Picolinate, L-Theanine can enhance the effects of ketamine, reducing total dose needed. helpful when treating depression.
Glucosamine sulfate - the body converts glucosamine into GAGs(glycosaminoglycan, mucus-like layer on the inner surface of the bladder) and hyaluronic acid, fortifying the bladder's mucus-like barrier to prevent urine toxins from damaging underlying tissues, reduces inflammation, helps tissue repair
NAC - reduces oxidative stress and inflammation.. helps prevents bladder tissue fibrosis by inhibiting inflammatory pathways and promoting tissue repair.
EGCG - (keep doses below 300mg a day for liver health)polyphenol from green tea, acts as a potent antioxidant and anti-fibrotic agent.. it helps protect against KIC(ketamine-induced cystitis) by reducing oxidative stress, interstitial fibrosis, and urothelial damage
Quercetin - a flavonoid with strong anti-inflammatory and mast cell-stabilizing properties, targets bladder inflammation common in IC(interstitial cystitis) like conditions...while direct KIC studies are limited, it's effective for IC symptoms (pain, urgency) via oral supplements, reducing histamine release and oxidative damage
Chondroitin sulfate - is a GAG component of the bladder's natural protective barrier, helping replenish the urothelial layer damaged by ketamine. It reduces inflammation and supports tissue repair
Hyaluronic acid - often paired with Chondroitin, is another key GAG that restores the bladder's lining, preventing urine penetration that exacerbates KIC inflammation and fibrosis
Aloe extract, Marshmallow, and Slippery Elm(likely overkill with all three but whatevs) - are demulcent herbs used to soothe irritated mucous membranes, including the bladder's urothelium... in KIC and interstitial cystitis/bladder pain syndrome, they help by forming a protective coating that mimics the damaged glycosaminoglycan (GAG) layer, reducing inflammation, irritation from urine toxins, and symptoms like pain, urgency, and frequency
D-Mannose - may ease urgency, frequency, and discomfort by modulating inflammation and supporting a healthier urinary environment, with some users reporting reduced flare-ups. D-Mannose binds to E. coli (the most common UTI-causing bacteria), preventing it from sticking to the bladder lining.. this flushes bacteria out during urination, reducing infection risk in damaged bladders prone to bacterial overgrowth due to ketamine's erosive effects(likely also unnecessary if your bladder is healthy, but doesn't hurt)
Fish Oil - beneficial for various inflammatory urologic conditions; may improve symptoms like pelvic pain and voiding dysfunction in IC
the main point for all this is to do everything possible to keep levels of these compounds up while your body metabolizes the ketamine. the halflife for ketamine is pretty short but its metabolites circulate for quite a bit longer and take longer to clear. thats why the constant NAC dosing and the doubling up on the Hyaluronic acid and Chondroitin morning and night.
i have been taking low dose(30-100mg sublingual) ketamine to help deal with some heavy grief that i just couldnt shake.. lots of random crying and feeling helpless.. coupled with some anxiety/depression. things had been going super great.. started to come out from under the cloud, was working through a lot... when after about a month of treatment i noticed i had some pelvic pain, was what i would consider mild but it was constant and really annoying. this was kind of distressing because i was just making some progress.. so i started researching and came up with this protocol. within 1 week(while still taking low dose ketamine) the pelvic pain completely went away(the bladder pain lasted about 2 weeks until i was a few days into this protocol). it's kind of a lot of work and not exactly cheap but it's a hell of a lot better than damaging your bladder.
this is also likely a bit overkill and i might make some adjustments if i feel like some stuff can be cut out.. but at this point im just happy i was able to address the bladder pain so quickly and reliably. also probably smart to get some urine test strips(these are plentiful and cheap) to check for blood. obviously if you start seeing some blood in your urine.. you should probably chill out on whatever youre taking.
and finally the best advice is.. if you notice any bladder/kidney issues.. you should just stop taking ketamine. though most cases of severe ketamine induced cystitis are from abusing ketamine for long periods of time.. with a lifetime limit of 200-300 grams for most people.
Last edited:
.
