Thanks Snozz! I have something slightly different but along the same lines to add
This isn't the same thing, but as people like me who use psychedelics to treat cluster headaches need to be aware that there is a potential for a "slap back" headache which is where you get an attack after busting a cycle.
There is no research on what causes the "Slap back" or how psilocybin even causes the prevention of CH.
"Everyone is different, but there often is an immediate sense of relief, followed within a few hours or a day or two, by the return of cluster attacks. These “slap-backs” can be abnormal attacks – shorter or longer than usual, or more painful or less painful than usual, and coming at odd times. There might be a few or several but these attacks then may begin to fade, at least for a while."
"The same treatments and coping methods used in the detox period can be used for these “slap-back” attacks and residual symptoms. Oxygen seems to be particularly effective when using the tryptamine treatment. For more on this, see
COPING: BUSTER-FRIENDLY TREATMENTS."
I haven't had any slap-backs with mushrooms, though I have had two with LSD.
I am curious to know if slap-backs are at all similar to what you have experienced.
The headaches from mescaline in the pdf sound similar to cluster headache to me.
[edit] after reading more evidence showing relation to cluster headache:
"The pain from headache is transmitted through a plexus of largely unmyelinated fibers that
surround the large cerebral vessels, pial vessels, large venous sinuses and dura mater to the ophthalmic division of the trigeminal ganglion"
This is the same location (Trigeminal) where cluster headaches are active. Cluster headaches are known as "trigeminal autonomic cephalalgias"
Very interesting! Please feel free to just say I'm making free association. Dr. Andrew Sewell who was one of the major researchers in unauthorized research on cluster headaches was involved in this study, so I could be totally wrong here.
[edit x2] seek and you shall recieve.
"Prolonged efficacy in terminating cluster periods and extending remission periods is difficult to explain as a consequence of receptor stimulation or antagonism, which should persist only for the duration of acute pharmacologic effect, or from receptor up- or down-regulation, which generally resolves over two weeks to two months. A number of other possibilities have been suggested, including disruption of the circadian rhythm through 5-HT1A, 5-HT2C, or 5-HT7 modulation, or through 5-HT2A-mediated gene induction (Sewell et al., 2006).
It would not be surprising if psilocybin both induced and treated headache by a related mechanism; however, this mechanism is as yet unclear."