Resveratrol as a RIMA?

[Rifle]

I've been hunting about for an option for a clear-headed RIMA for use with sublingual DMT administration and came across resveratrol. I was surprised to find there hasn't been any real exploration of resveratrol on the nexus.

I'm most interested in also administering it sublingually, like the DMT. Wikipedia had interesting information in this regard. It appears resveratrol is not effectively absorbed orally, because 1mg of it delivered sublingually have an order of magnitude higher blood concentration of it than 250mg delivered orally. The main problem is it does not really dissolve in water so an alcoholic solution will be required.

I have some 10x B. caapi tincture I'm going to explore first. I might stick with just that if I'm satisfied since it's tried and true, but if it's not quite what I was hoping for I may very well explore resveratrol as a RIMA in the future. It could be awhile since I probably won't explore sublingual DMT until the weather is nice in the temperate regions of the northern hemisphere, but I thought I would get this out there in case it may interest others as well.

 

[AlbertKLloyd]

I think it is worth a try.

 

[John Smith]

This is very interesting, I've been involved with resveratrol research/use myself in the past and never even realised it could be used as RIMA. From what I've read, you're right, resveratrol is not very bio-available orally. Blood plasma concentrations are low when compared to absorption through oral mucosa. Problem is though, you can't just take regular resveratrol, put it under your tongue and expect the results like you do it with extracted harmalas. It's got it's own issues why it doesn't work well bucally/sublingually(solubility issues etc).

It is still worth trying however. There's such a great variety of resv formulations that some of them might just work. Some use additives to increase bio-availability. Theres also particle size reduced resv which helps with that problem.

"Mesh 80" is about 0.178mm particles
"Mesh 120" is about 0.12 mm particles (120um)
"Micronized" particles are about 1.0 um and in some cases lower.

I still have some leftovers from a 25gram bag of M98 Micronized I bought years ago. I found there's a definitely a subtle effect when I use about one 300mg scoop, spread it carefully between gums and cheeks and just keep it there for prolonged periods of time(also use the finger the spread it where it clumps too much). I don't like sublingual since saliva tends to wash it away too quick.

Now the problem lies with dosages, I'm wondering the amounts required to achieve enough MAO inhibition for sublingual dmt to work. Theres around 10 grams left in that old bag(expired '11 tho) Ill see what comes out it. Also, I should make spice fumarate, right ?

 

[Rifle]

Yeah, sounded like I couldn't just put it under my tongue but I thought maybe having it dissolved in diluted alcohol would work. I don't really mind the burn from a 50% alcohol-water mixture. Wouldn't do it that way if I was going to do it frequently though.

I plan on using spice acetate when I do it sublingually as per this thread: Sublingual DMT tincture: Story and Recipe. (NO BURN, NO NAUSEA) - Other - Welcome to the DMT-Nexus

Thread mentions fumarate working as well.