Safety of Acetonitrile as a Solvent for 1P-LSD?

[Swarupa]

My friend has some liquid solution of 1P-LSD but i see that acetonitrile is the solvent used, i'm curious about the safety of ingesting this liquid.

The wiki linked above states that 'Acetonitrile has only a modest toxicity in small doses' but i wonder how this translates to the real world application of the liquid solution which is dosed at 50mcg 1P-LSD per drop. I've searched but can't find any information in regards to what amounts it becomes a concern ingesting liquid acetonitrile, "The levels causing toxicity in man are unknown but are probably in excess of 840 mg/m3 (500 ppm) in air" is all i could find so far.

Thanks in advance for any information about the safety this solvent.

 

[NotTwo]

Acetonitrile has an oral LD50 of 2460 mg/kg which means it's only harmful if you drink a fair bit (someone weighing 70 kg would need to dring 70 * 2.460 = 172 grams of it to have negative effects and a lot more than that before it was classed as toxic). So for the amounts you're talking about there's really nothing to worry about.

 

[Swarupa]

Acetonitrile has an oral LD50 of 2460 mg/kg which means it's only harmful if you drink a fair bit (someone weighing 70 kg would need to dring 70 * 2.460 = 172 grams of it to have negative effects and a lot more than that before it was classed as toxic). So for the amounts you're talking about there's really nothing to worry about.

Thanks for the input NotTwo, i saw the LD50 for rats was 2460 mg/kg on the wiki but wasn't sure how this translates to humans, if the same is true for humans then surely if someone weighing 70kg ingested 172grams that would be equivalent to the approximate lethal dose, rather than non-toxic negative effects as you suggested? Maybe i'm misunderstanding how toxicity is determined from the LD50.

 

[NotTwo]

Thanks for the input NotTwo, i saw the LD50 for rats was 2460 mg/kg on the wiki but wasn't sure how this translates to humans, if the same is true for humans then surely if someone weighing 70kg ingested 172grams that would be equivalent to the approximate lethal dose, rather than non-toxic negative effects as you suggested? Maybe i'm misunderstanding how toxicity is determined from the LD50.

Hey, sorry, Swarupa. I think what I said was really misleading! My apologies

The LD50 value is the amount at which 50% of the species die when administered that dose. Because rats and humans are both mammals you can make an extrapolation and say there's a reasonable chance that what happens in a rat will also happen in a human.

So give 10 humans weighing 70kg 172g each and probably 5 of them will die.

I guess the good news is that 50mcg is a lot, lot less that 172g.

 

[Swarupa]

Don't worry about it NotTwo, no harm done

I guess the good news is that 50mcg is a lot, lot less that 172g.

Well 50mcg is the amount of 1P-LSD in each drop of the solution, i'm not sure how much the liquid acetonitrile itself weighs, i know it's less dense than water, 786 kg/m³ and 999.97 kg/m³ respectively... working on the assumption that 172g is the approximate LD50 for a 70kg human, and that 1 drop of acetonitrile is 0.05ml, then i work it out that the mass of 1 drop of acetonitrile should be 0.0393 gram, which makes the LD50 for a 70kg human approximately 4,376 drops. What this means for the toxicity of a common dose of 1-4 drops (50-200mcg) i'm not sure, comparing it with the common dose and LD50 of some of our favorite substances it looks promising, although i think i'll probably stick to the blotters for the time being.

 

[downwardsfromzero]

Seems to me the liquid is best used for putting on a blotter, thus you'll hopefully avoid ingestion of acetonitrile by waiting long enough for it to have evaporated completely.

 

[Swarupa]

That's a great idea downwardsfromzero, it looks like it could evaporate at room temp within a few hours as it evaps within 55 minutes in a 35°C bath.

My friend has plenty of 1P-LSD blotter already so it could be a good idea to drop it onto some sweets and let it evaporate in a well ventilated area. I don't have much of a sweet tooth so wonder what else could be dropped onto... maybe some mints would be nice.

 

[downwardsfromzero]

[...]it could be a good idea to drop it onto some sweets and let it evaporate in a well ventilated area. I don't have much of a sweet tooth so wonder what else could be dropped onto... maybe some mints would be nice.

Maybe it would be better to drop it onto something children might not want to eat? Cabbage leaves? /jk

 

[Ufostrahlen]

[...]it could be a good idea to drop it onto some sweets and let it evaporate in a well ventilated area. I don't have much of a sweet tooth so wonder what else could be dropped onto... maybe some mints would be nice.

Maybe it would be better to drop it onto something children might not want to eat? Cabbage leaves? /jk

Kids mostly don't eat kids. But don't drop it on them! They might absorb the 1p thru the skin. :lol: *scnr*

 

[Kenota]

If you want a thorough overview of the safety, using the ICH pharmaceutical residual solvents limits is a good guide for 100% chance of safety. If you used the solution as is, you are allowed 4.1mg of MeCN per day, so if you trip once a month, you are allowed approx 125mg per month. Given a drop is roughly 40mg, you can have 3 drops each time and be guaranteed no ill effects. That said, these limits are super stringent, using the same limits for alcohol would mean you would only be allowed one pint of beer a year based on their suggestions for residual ethanol basically, this amount of MeCN is of no risk whatsoever. Worry not, even if you decide to drip it straight down your gullet.

 

[downwardsfromzero]

[...]it could be a good idea to drop it onto some sweets and let it evaporate in a well ventilated area. I don't have much of a sweet tooth so wonder what else could be dropped onto... maybe some mints would be nice.

Maybe it would be better to drop it onto something children might not want to eat? Cabbage leaves? /jk

Kids mostly don't eat kids. But don't drop it on them! They might absorb the 1p thru the skin. :lol: *scnr*

Kids do eat sweets though. They sometimes even seek them out from hidden places and steal them... no /jk

"better to drop it onto something that children might not want to eat?"


<I'm assuming Ufostrahlen's first language is likely to be German and I can fully understand any misunderstanding that may have arisen.>