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sublingual ..DMT blotter?

For me the issue is not about agreeing with your ideas or not, it's about maintaining a dialogue based on mutual understanding rather than misunderstanding.
 
Ernestine said:
For me the issue is not about agreeing with your ideas or not, it's about maintaining a dialogue based on mutual understanding rather than misunderstanding.
Click to expand...
well... I at first thought you had to be talking about ....oral method...that always takes larger doses ...

because i would never take 50 rue seeds under my toung...10 seeds or less would work for me..just fine...:alien:

your welcome to keep comunicating if you like ...now that this issue is understood better..
 
interesting info...




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These are results for why? some drugs don't work under tongue?
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Not all drugs are suitable for sublingual administration because several factors can affect their absorption through the oral mucosa
.
Here's why some drugs don't work effectively when taken sublingually:
1. Drug Properties:
  • Solubility: A drug needs to dissolve readily in saliva to be absorbed sublingually. If it's not sufficiently water-soluble, it won't dissolve quickly enough for effective absorption.
  • Lipid Solubility: After dissolving in saliva, the drug also needs to be able to pass through the lipid-rich cell membranes of the oral mucosa to enter the bloodstream. A drug that's too hydrophilic (water-loving) or too lipophilic (fat-loving) might not be absorbed efficiently.
  • Molecular Size: Larger molecules might have difficulty diffusing through the oral mucosa.
  • pH and Stability: The pH of saliva and the stability of the drug in the salivary environment can also influence sublingual absorption.
2. Drug Formulation:
  • Form of the Drug: Sublingual tablets or films are specially formulated to disintegrate quickly and release the drug for absorption. Regular tablets or capsules may not be designed for this route and may not release the drug properly.
  • Fillers and Excipients: Some medications contain fillers or excipients that might not be suitable for sublingual administration and could hinder absorption or cause irritation.
3. Patient Factors:
  • Excess Saliva: Excessive salivation can wash away the drug before it's absorbed.
  • Mouth Sores or Irritations: Open sores or irritations in the mouth can affect absorption and cause discomfort.
4. Drug Design & Targeted Release:
  • Sustained-Release Formulations: Some drugs are formulated for sustained or extended release in the gastrointestinal tract. These formulations are not suitable for sublingual use.
  • Drugs Requiring Gastric Acid: Some medications need to be exposed to stomach acid for optimal absorption or to activate the drug. Sublingual administration bypasses the stomach, making it ineffective for these types of drugs.
In summary, for a drug to be effectively absorbed sublingually, it needs to possess specific properties and be formulated appropriately. If a drug doesn't meet these criteria, it may not be absorbed efficiently and may not produce the desired therapeutic effect when taken sublingually.




  • Are sublingual medications formulated differently, or can most ...
    Oct 20, 2019 — * Allan Silverman. Former President “ American Pharmacists Union (1998–2012) · 5y. Sublingual medications have to lend themselves to several criteria . Firstly,...
    favicon

    Quora


  • Sublingual Administration Guide: Examples and Definition - GoodRx
    Feb 15, 2023 — But there are many factors that can affect how much of an oral medication makes it to your blood, including: * Your age. * Other medical conditions you have. * ...
    favicon

    GoodRx


  • Sublingual administration - Wikipedia
    Principle. When a chemical comes in contact with the mucous membrane beneath the tongue, it is absorbed. Because the connective tissue beneath the epithelium co...
    favicon

    Wikipedia
Show all


This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes.


Featured snippet from the web

Sublingual administration doesn't work for medications that need to be released slowly. Some tablets or capsules are formulated to prolong the medication's release into the body. This includes sustained-release products. For these medications, sublingual administration usually isn't a good idea.




on HPBCD.......


HPBCD is known for its excellent solubilizing properties, making it a valuable excipient in pharmaceutical formulations. It can enhance the solubility and bioavailability of poorly soluble drugs, improving their therapeutic efficacy.

HPBCD:Hydroxypropyl-Beta-Cyclodextrin - Ontosight.ai

1747136099093.png
Ontosight.ai
https://ontosight.ai › Glossary › T






About featured snippets•

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Is HPBCD soluble in water?


HPBCD is itself very soluble in water (greater than 500 mg/ml at room temperature compared to 18 mg/ml for β-Cyclodextrin).

DMT freebase... is more soluble in warm or hot water...but poorly soluble in cold water]
 
Last edited:
1Starway7 said:
interesting info...




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Web
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Search Results

These are results for why? some drugs don't work under tongue?
Search instead for why? some drugs wont work under toung?


AI Overview

AI Overview
Learn more

Not all drugs are suitable for sublingual administration because several factors can affect their absorption through the oral mucosa
.
Here's why some drugs don't work effectively when taken sublingually:
1. Drug Properties:
  • Solubility: A drug needs to dissolve readily in saliva to be absorbed sublingually. If it's not sufficiently water-soluble, it won't dissolve quickly enough for effective absorption.
  • Lipid Solubility: After dissolving in saliva, the drug also needs to be able to pass through the lipid-rich cell membranes of the oral mucosa to enter the bloodstream. A drug that's too hydrophilic (water-loving) or too lipophilic (fat-loving) might not be absorbed efficiently.
  • Molecular Size: Larger molecules might have difficulty diffusing through the oral mucosa.
  • pH and Stability: The pH of saliva and the stability of the drug in the salivary environment can also influence sublingual absorption.
2. Drug Formulation:
  • Form of the Drug: Sublingual tablets or films are specially formulated to disintegrate quickly and release the drug for absorption. Regular tablets or capsules may not be designed for this route and may not release the drug properly.
  • Fillers and Excipients: Some medications contain fillers or excipients that might not be suitable for sublingual administration and could hinder absorption or cause irritation.
3. Patient Factors:
  • Excess Saliva: Excessive salivation can wash away the drug before it's absorbed.
  • Mouth Sores or Irritations: Open sores or irritations in the mouth can affect absorption and cause discomfort.
4. Drug Design & Targeted Release:
  • Sustained-Release Formulations: Some drugs are formulated for sustained or extended release in the gastrointestinal tract. These formulations are not suitable for sublingual use.
  • Drugs Requiring Gastric Acid: Some medications need to be exposed to stomach acid for optimal absorption or to activate the drug. Sublingual administration bypasses the stomach, making it ineffective for these types of drugs.
In summary, for a drug to be effectively absorbed sublingually, it needs to possess specific properties and be formulated appropriately. If a drug doesn't meet these criteria, it may not be absorbed efficiently and may not produce the desired therapeutic effect when taken sublingually.




  • Are sublingual medications formulated differently, or can most ...
    Oct 20, 2019 — * Allan Silverman. Former President “ American Pharmacists Union (1998–2012) · 5y. Sublingual medications have to lend themselves to several criteria . Firstly,...
    favicon

    Quora


  • Sublingual Administration Guide: Examples and Definition - GoodRx
    Feb 15, 2023 — But there are many factors that can affect how much of an oral medication makes it to your blood, including: * Your age. * Other medical conditions you have. * ...
    favicon

    GoodRx


  • Sublingual administration - Wikipedia
    Principle. When a chemical comes in contact with the mucous membrane beneath the tongue, it is absorbed. Because the connective tissue beneath the epithelium co...
    favicon

    Wikipedia
Show all


This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes.


Featured snippet from the web

Sublingual administration doesn't work for medications that need to be released slowly. Some tablets or capsules are formulated to prolong the medication's release into the body. This includes sustained-release products. For these medications, sublingual administration usually isn't a good idea.




on HPBCD.......


HPBCD is known for its excellent solubilizing properties, making it a valuable excipient in pharmaceutical formulations. It can enhance the solubility and bioavailability of poorly soluble drugs, improving their therapeutic efficacy.

HPBCD:Hydroxypropyl-Beta-Cyclodextrin - Ontosight.ai

View attachment 103408
Ontosight.ai
https://ontosight.ai › Glossary › T






About featured snippets•

Feedback

People also ask

Is HPBCD soluble in water?


HPBCD is itself very soluble in water (greater than 500 mg/ml at room temperature compared to 18 mg/ml for β-Cyclodextrin).

DMT freebase... is more soluble in warm or hot water...but poorly soluble in cold water]
Click to expand...
More info..

because of water solubility ....I thought about using DMT salts using ....acetic acid...acetate....[white vinegar]..... sublingualy... instead of free base .... and ...BELOW.... is what i found on salts of DMT..........

some choice of salts that could be used..,,,,[acetic acid.[vinegar....succinate...tartrate....maleate...phosphate...citrate...fumerate..ect

I guess we need help from a real chemist!



AI Overview
Learn more

While sublingual administration of DMT salts is theoretically possible, it's not a common or well-established method and comes with significant caveats
.
Here's why and what you should know:
1. Why it's theoretically possible:
  • DMT salts, such as DMT fumarate, are water-soluble, which is a characteristic that generally allows for sublingual absorption.
  • The sublingual route allows for direct absorption into the bloodstream through the mucous membranes in the mouth, bypassing the first-pass metabolism in the liver.
2. Why it's not commonly used and the caveats:
  • Limited Bioavailability: While DMT salts are water-soluble, they might not be readily absorbed through the sublingual mucosa, resulting in low bioavailability.
  • Dosage and Effects: Due to the uncertain bioavailability, it is very difficult to determine the appropriate dose for a sublingual DMT salt experience, making it potentially unpredictable.
  • Lack of Research: There's a scarcity of scientific research on the sublingual administration of DMT salts, meaning its effectiveness and potential side effects are not well understood.
  • Alternative Routes are More Established: Routes like inhalation (vaporizing) or intravenous injection are more widely used and have established dosage guidelines and expected effects for DMT.
3. Important Considerations:
  • Safety Concerns: DMT is a potent psychedelic, and experimenting with less-studied routes of administration can be risky.
  • Consult with Professionals: If you are considering DMT use, it's essential to consult with a medical or psychedelic professional who can guide you based on current research and best practices.
  • Dosage is Crucial: As with any psychedelic, determining a safe and effective dose of DMT is critical, and using sublingual methods for which no dosing guidelines exist is discouraged.
  • Set and Setting: Remember to always consider the importance of "set and setting" – your mental state and the environment in which you use psychedelics.
In summary: While sublingual administration of DMT salts is theoretically possible, it's not a widely used or researched method, and its effectiveness and safety are not well-established. If you are considering using DMT, research the topic carefully and seek guidance from qualified professionals
 
Last edited:
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