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sublingual ..DMT blotter?

I was using acetates and fumarate…with harmala hcl from rue. I was doing it often back around 2012-2014. Sometimes I could get away with 25mg harmalas and 15-25mg DMT when it absorbed properly.

2 months ago I drank 2.5 grams of rue and after 2 hours I took just 15 mg sublingual acetate goo with decent effects. Having a full dose of oral harmalas helps I assume.

I think my favourite way to do it is to predose with 12.5-25 mics LSD. After 3-4 hours I then take around 25mg harmalas and whatever dose of DMT…it’s usually low tbh. I can always vape a bit.
 
Jamie01 said:
To clarify, I dose the harmalas first then the DMT but I don’t wait too long between them.
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How long did your trip last?
Did you get mostly closed eye visions/








just a note..
What characteristics of molecule enable it to be transdermal?


With current delivery methods, successful transdermal drugs have molecular masses that are only up to a few hundred Daltons, exhibit octanol-water partition coefficients that heavily favor lipids and require doses of milligrams per day or less



NN DMT molecule has a molar mass of about ...188.274 daltons.. ...looks small enough to be delivered transdermally through skin...
not shure what this below means?...
[exhibit octanol-water partition coefficients that heavily favor lipids]


watch Tales from the trip...full screen
 
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Peak is only like 15-20 minutes really. It depends on the harmala dose though.

At the doses I take I have mostly closed eye visions and some typical open eye visuals.
 
Ok.. ive been buisy latley but i got another idea for blotter DMT

In photos below im still using thin coffie filter paper ..the long shiny strip of filter paper has been soaked in a mix of ....grain alcohol...DMT freebase/HPBCD powder blend].... that mixed nicely while in the liquid state...
When the two were mixed together... it became like a ball of melted plastic as they fused together ......[maybe complexing?] ...... and became more liquid with more mixing...
At first... The shiny strip was foulded many times in a square blotter shape.. but i un foulded the paper allowing the alcohol to leave the paper dry ..and feeling like a thin plastic...
Its shiney like the glue you lick on an envolope to seal a letter...
I could refould the strip ...or just cut sections out of it.. to test it sublingually.....the strip feels like a thin plastic through and through on booth sides witch means as soon as the paper is placed under toung it should get very sticky! and stay where it is placed for a while ..
Right now its just straight dmt freebase .... blended...or complexed into HPBCD .... powder..
Im in NO WAY!! claiming that this works ...as Trevor ... that used to be on nexus has claimed... only im curious... and using a different application than the ....liquid in a tea spoon method...]. that was Trevors method...
This is a test...this shiney slick plastic like strip has then two elements complexed together.. ....[forming a clear glue like mixture of dmt and hpbcd powder] ...as ive read in my research..
the sticky strip should hold the two elements together under the tounge for a while sticking where its placed under toung.. preventing fast run down the throat like a liquid from a dropper would do.......I AM MAKING NO CLAIMS THIS IS JUST A TEST1
The shiny coating in photo below is compleatly dry to the touch feels like thin plastic ..the ... now dry.. HPBCD powder is holding the... mixed in... or complexed DMT in place...Hopefully to use as a sublingual blotter... The last 4 pictures are my attempt to get a close up shot ..of the sublingual strip...
i tasted the sublingual strip...it was very bitter! The strip has a crystalized apearence... see what it looks like in morning...

Non-polar note

DMT (dimethyltryptamine) is non-polar123. It is insoluble in polar solvents like water, ....[[[[[but dmt can desolve in hot water]]]]....but soluble in non-polar solvents like Naphtha, Xylene, Hexane, and Heptane2. When DMT is mixed with a polar base solution, it can be separated from the base solution using a non-polar solven

[ below info taken.... from internet...not shure how acurate it is? I could not get this method below to work the last time it was on nexus...when there were several others that claimed it worked for them? .... may be i did something wrong?


HPBCD is a new technology that allows freebase nonpolar drugs like DMT to be trapped by the cyclodextrin inner cavity which is composed of an inner "non-polar trap", and "outer polar cavity or cone" which allows the normally water insoluble DMT to be made 100% water soluble.

HPBCD is composed from a sugar molecule, it has been used to make scores of other non-water soluble drugs 100% water soluble and reach peak activity as measurements of the drug in the bloodstream indicated that all of the freebase drug was absorbed effectively.

HPBCD is a new technology that allows freebase nonpolar drugs like DMT to be trapped by the cyclodextrin inner cavity which is composed of an inner "non-polar trap", and "outer polar cavity or cone" which allows the normally water insoluble DMT to be made 100% water soluble.

HPBCD is composed from a sugar molecule, it has been used to make scores of other non-water soluble drugs 100% water soluble and reach peak activity as measurements of the drug in the bloodstream indicated that all of the freebase drug was absorbed effectively.

[[maybe one could use corn starch as a substitute for HPBCD?]]:unsure:

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Varallo said:
Nice test, I’m looking forward to seeing an in vivo assessment of this.
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using dmt tincture containing 1 to 3 mgs of dmt free base per drop ,.... with a little added methanol to delute the HPBCD powder
I soaked the paper strip locking all the actives into the blotter paper...i tryed to complex the two ellements by mixing them together in the methanol..
they apeared to mix well into each other forming a melted plastic like ball that thinned back out into the ethanol..[should i have just used hot water?
then Last night ..I just tryed 1/3rd of strip ..foulded up to a square blotter ..all alcohol compleatly gone and dry ..after the blotter was wet it had a tolorable burn under toung..
The blotter held the actives well!
After total saturation of blotter the actives stayed in same area under toung the light burn getting a little stronge!...r felt as if the sublingual pores were opening up......
Could tell something was happening with that light burn ...I could notice very subtle things going on... as i observed minor movement of walls and other objects in room...
Still this test was only on DMT/HPBCD blotter only....NO Harmalla in the mix....! my enzimes may have attacked and destroyed most of dmt without the presence of harmalla??
1746913695070.jpeg

14:23


YouTube · DUST watch full screen..

Sci-Fi Short Film "Big Boom" | DUST
YouTube · DUST
Apr 19, 2023
 
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1Starway7 said:
Since i dont have any processed harmala......and,,since rue is very potent]....im thinking of 4 or 5 small rue seeds held under toung ....

....30 or 40 minutes before putting DMT blotter under toung.....or packing the seeds in the foulds of the blotter paper...im guessing,, rue under toung...30 minutes before the blotter may work best...[i know this.. [rue first]..method works well when vapeing dmt...]

with saftey in mind...[i could also try ...passion flower.. as a weaker substitute for rue?:unsure:

This all depends on..if the DMT is getting through sublingualy in large enough amount...
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I think that's nowhere near enough. I use 400mg of seeds chewed and held by the gums for vapourhuasca. Never counted them out but i think that's more like 50 seeds than 5.
 
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Ernestine said:
I think that's nowhere near enough. I use 400mg of seeds chewed and held by the gums for vapourhuasca. Never counted them out but i think that's more like 50 seeds than 5.
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Maybe it depends on the species of rue seeds/?

I have chewed as little as 6 or 7 seeds...held under toung ...then 15 minutes later vaped dmt.... and got fairly strong effects from the seeds..

why? make your. body.. do extra work ... bringing you back to baseline? ... with a huge amount of seed? ....rue isnt candy!......rue is effective.... and like anything else... it has a dark side... as well as a bright side...i handel it with respect...
 
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Since i dont have any processed harmala......and,,since rue is very potent]....im thinking of 4 or 5 small rue seeds held under toung ....

....30 or 40 minutes before putting DMT blotter under toung.....or packing the seeds in the foulds of the blotter paper...im guessing,, rue under toung...30 minutes before the blotter may work best...[i know this.. [rue first]..method works well when vapeing dmt...]

with saftey in mind...[i could also try ...passion flower.. as a weaker substitute for rue?:unsure:

This all depends on..if the DMT is getting through sublingualy in large enough amount...
 
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I have tried 200mg before and prefer 400. I used to use 800, worked my way down to 200 and now settled around 3-500. By my calculations 400mg is about 12mg of alkaloids, based 0.03% of total seed weight, 24mg if it's 0.059%. I think those who use extracts are using about that amount. I think each seed weighs about 3mg so you would be getting about 0.63 -1.26mg of alkaloids. Is that enough to provide the inhibitory action needed?
 
Ernestine said:
I have tried 200mg before and prefer 400. I used to use 800, worked my way down to 200 and now settled around 3-500. By my calculations 400mg is about 12mg of alkaloids, based 0.03% of total seed weight, 24mg if it's 0.059%. I think those who use extracts are using about that amount. I think each seed weighs about 3mg so you would be getting about 0.63 -1.26mg of alkaloids. Is that enough to provide the inhibitory action needed?
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This is my conclusion aswel. Rue has an yield of about 2 to 6% of alkaloids, my rue is usually around 6 percent. That means you would need for a dose between 1 gram and 0.33 gram of seeds to get an regular dose of 20mg.

1Starway7 said:
Since i dont have any processed harmala......and,,since rue is very potent]....im thinking of 4 or 5 small rue seeds held under toung
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This means even if you are in the most potent range you would be consuming 1,5 mg of harmalas. I am sure that most people would never be able to feel anything from that dose.
1Starway7 said:
why? make your. body.. do extra work ... bringing you back to baseline? ... with a huge amount of seed? ....rue isnt candy!......rue is effective.... and like anything else... it has a dark side... as well as a bright side...i handel it with respect...
Click to expand...

I have a hard time believing that these amounts do anything, for most that is.
 
Varallo said:
This is my conclusion aswel. Rue has an yield of about 2 to 6% of alkaloids, my rue is usually around 6 percent. That means you would need for a dose between 1 gram and 0.33 gram of seeds to get an regular dose of 20mg.



This means even if you are in the most potent range you would be consuming 1,5 mg of harmalas. I am sure that most people would never be able to feel anything from that dose.


I have a hard time believing that these amounts do anything, for most that is.
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The reason why ...very low doses of rue... work and are felt... is because is because of the method of administration ... is...sublingual!

Sublingual administration... takes ... WAY LESS of everything .... to have effect..... than ....oral administration.

I can even feel the rue using the sublingual method...before vaping DMT also..it has a large effect .... the smaller dose may not last as long as a larger doses like say a cup of rue tea using 80 seeds.... sublingual is the economical and fast way ...short of injecting...

[sublingual method goes straight into the bloodstream]] ... and by passes the gut on first pass... thats why....[ less is more].... when using sublingual...
 
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1Starway7 said:
The reason why ...very low doses of rue... work and are felt... is because is because of the method of administration ... is...sublingual!

Sublingual administration... takes ... WAY LESS of everything .... to have effect..... than ....oral administration.

I can even feel the rue using the sublingual method...before vaping DMT also..it has a large effect .... the smaller dose may not last as long as a larger doses like say a cup of rue tea using 80 seeds.... sublingual is the economical and fast way ...short of injecting...
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I think we are all talking about buccal and sublingual routes. For oral route several grams are used. Take care not to condescend.
 
Ernestine said:
I have tried 200mg before and prefer 400. I used to use 800, worked my way down to 200 and now settled around 3-500. By my calculations 400mg is about 12mg of alkaloids, based 0.03% of total seed weight, 24mg if it's 0.059%. I think those who use extracts are using about that amount. I think each seed weighs about 3mg so you would be getting about 0.63 -1.26mg of alkaloids. Is that enough to provide the inhibitory action needed?
Click to expand...
im only talking about the ....sublingual method..... requires much less of what your taking to have a strong effect....compaired to the ....oral mthod] that has to go through the stomach and gut and some of that is wasted before it reaches the blood stream...
 
Now you're not even reading/comprehending.

Buccal is only slightly less efficient than sublingual for traditional drugs. When we are holding chewed seeds in the buccal pouch the juice will also be hitting the sublingual mucosa. I find it uncomfortable and inconvenient to hold the seeds there for a session.
 
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Ernestine said:
I think we are all talking about buccal and sublingual routes. For oral route several grams are used. Take care not to condescend.
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Well i must be very sensitive to rue.... because ...[sublingualy]....very small doses are easily noticed after adding DMT...just my experiance...
 
 
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1Starway7 said:
just speaking from my own experiance..im not new here...ive been on nexus since 2012
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No, you were responding to me and Varallo and insinuating that we are misunderstanding the differences between the oral and sublingual routes and hence the amounts required. We are not.

Others can easily judge just how good your comprehension is from what you have written in response.
 
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Ernestine said:
No, you were responding to me and Varallo and insinuating that we are misunderstanding the differences between the oral and sublingual routes and hence the amounts required. We are not.

Others can easily judge just how good your comprehension is from what you have written in response.
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Im sorry that you feel this way ...i was only responding to ...YOU... ...[ernistine.]........not varallo!.....if you dont agree with my ideas..... you need not respond...

after all... this is just a test... im not making any claims yet.... and im not going to waste my time arguing with people who are just looking for an argument...

Have a nice day!
 
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