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Synthetic Tryptamines with Harmaloids ,which are safe ?

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Observant

Observant

Nothing Stops The Void
Have you tried ? Is there something one should know about ?

I think its no problem to combine with DET , as its a chill experience .

But I am not so sure about AMT , because of its stimulating properties

What about DPT ?


Are there any known dangers one can avoid ?
 
I have heard some bad things from people about AMT...

The only person I met who liked it was some guy at a psytrance festival..and the way he described it even did not sound like my cup of tea..sounded more like a real amphetamine..not in the way mescaline is stimulating but more like a real amphetamine with some LSD like qualities.

I would be very careful combining AMT with MAOI's
 
How strong of an Maoi is AMT , Benzyme ? Does it compare with harmine ? Can it activate dmt orally ?

Tihkal said:
In the 1960's there was quite a bit of interest at a couple of pharmaceutical houses in the indole analogues of amphetamine. Both the alpha-methylated tryptamine (AMT) and the alpha-ethylated homologue (AET) were found to be effective monoamine oxidase inhibitors, and both were clinically studied as potential antidepressants. The ethyl compound became a commercial drug, offered by the Upjohn Company as Monase, but now is considered to be without medical use and is a Schedule I drug. It is interesting that this methyl compound, AMT was also a medically available antidepressant in the Soviet Union in the 1960's and was sold under the name of Indopan, in 5 and 10 milligram tablets. (pg 567)
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Seems to be a clear contraindication .



@fractal I know several people who liked AMT , okay granted they are several people from psytrance festivals ;)



What about DET and DPT ? Do you think they are safe to enhance with Harmaloids ? DET at least felt safe ...
 
benzyme said:
fractal enchantment said:
I would be very careful combining AMT with MAOI's
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AMT is an MAOI
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I guess I meant combining it with harmala alkaloids..simply taking more AMT on top of another dose of AMT I would think would differ from adding harmalas to AMT..

I am not saying it cannot be done..but it might be too stimulating nad uncomfortable etc..

I was going to try AMT a while back..but decided not to after talking to some other people.
 
Observant said:
How strong of an Maoi is AMT , Benzyme ? Does it compare with harmine ? Can it activate dmt orally ?
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depends on the dosages and half-lives.. binding affinity and duration of action.
they're both reversible inhibitors, which are fine.
just play it safe.. always avoid irreversible inhibitors like Nardil.

and yes, I'd imagine dmt would be orally active with IT-290
 
fractal enchantment said:
I have heard some bad things from people about AMT...

The only person I met who liked it was some guy at a psytrance festival..and the way he described it even did not sound like my cup of tea..sounded more like a real amphetamine..not in the way mescaline is stimulating but more like a real amphetamine with some LSD like qualities.

I would be very careful combining AMT with MAOI's
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thats pretty much how it felt to me... supposedly at higher doses it's more psychedelic and less speedy, but i never felt comfortable enough to take it that far(i dont like stimulants, i have mild anxiety). ...only tried it a few times, several years ago. apparently some people really enjoy it, though.
 
DPT no problem done it many times. You will be purging on a moderate dose and up. The most I did wad 250mg with 7grams rue. It blew my head right off was quite uncomfortable from the onset thru and a bit past the purge then it was enjoyable. IM is the way to go with DPT bypass the stomach and the side effects are dramatically reduced. Its a trip but I never got profound mental effects like the other classic psychedelics.

I have also rue combo with numerous other tryptamines and found no trouble. Now that does not mean it is safe but I have never had any issues with it. Every tryptamine I have ever come across I have combo as well no apparent ill effects for me.

I do not like speedy AMT so I never did that one that is because I do not do AMT


PEACE
MV
 
Honestly, not enough is known about these synthetic tryptamines to be able to say "yes it is safe". Some of the tryptamines might not be safe by themselves, much less with an MAOI.

I would avoid the combinations completely.

Stretching your $ or £ or ¥ with an MAOI is not worth your life!
 
Yes agonists of seretonin receptions combined with things that inhibit the break down of seretonin as well as the break down of the agonists can cause seretonin syndrome which can be life threatening. Many safe combinations of tryptamines and MAOI's are already known so its best to stick with those (acid shrooms dmt etc). The pharmacology of some of these research tryptamines is still largely unknown.
 
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