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syrian rue MAOI dose ineffective

H

hypertestudo

Esteemed member
Why might the following syrian rue dose appear to be ineffective as an MAOI to potentiate freebase DMT?:
*500mg syrian rue seeds crushed in mortar and pestle
*crushed seeds taken sublinguially for 15-20 minutes, the:n swallowed
*5-10mg freebase DMT vaped at 60 minutes and 90 minutes after sublingual application of crushed seed, with no apparent enhancement or lengthened duration of the vaped DMT.
Is the seed dose too low? is the time from seed application to vaping too long? is the seed application (crushed sublingual, then swallowed) a poor method?
Any other ideas on ineffectiveness of the MAOI?
 
Hi. Half a gram is not enough for full mao inhibition, and also if solid seed material is used, it has an extended digestion time, especially if not thoroughly chewed or finely powdered. I don't have knowledge on the sublingual absorption, however I would guess that it would not be effective if seeds are not finely powdered.
 
Hi, and thanks for the reply.
dithyramb said:
Half a gram is not enough for full mao inhibition
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What might be a satisfactory dose for sufficiently powdered or chewed syrian rue seeds? 800mg?

dithyramb said:
if solid seed material is used, it has an extended digestion time, especially if not thoroughly chewed or finely powdered. I don't have knowledge on the sublingual absorption, however I would guess that it would not be effective if seeds are not finely powdered.
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What might be a recommended technique for thoroughly chewing? Just chew and swallow? The seeds are already so fine, it seems that they would get stuck in the teeth and gums.

Perhaps a pepper grinder might be superior tool or method for grinding the seeds to a finer powder?
 
Pharmahausca forum-threads seem to suggest 2g of chewed, finely powdered, or other well prepared method of syrian rue is a satisfactory starting dose for a rookie psychonaut.

Minty Love on youtube suggests 500mg to 800mg chewed and sublingual, but that dose might be too low for even a rookie.
 
yes I also think crushed seeds would not be effective for the sublingual route, the purified alkaloids work very well though. One easy option would be to smoke the seeds before smoking the DMT, just 1 hit would be enough. and then i would wait 10-15 mins to be ready for DMT.
smoking the seeds directly can be harsh but if done gently it's not that bad.
 
Sakkadelic said:
yes I also think crushed seeds would not be effective for the sublingual route, the purified alkaloids work very well though. One easy option would be to smoke the seeds before smoking the DMT, just 1 hit would be enough. and then i would wait 10-15 mins to be ready for DMT.
smoking the seeds directly can be harsh but if done gently it's not that bad.
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I've quidded whole seeds in sub-gram doses a lot, and the effect is subtle at the most. I haven't any specific accounts to share of combining it with vaped DMT, but based on comparisons with a rue brew and oral 'light' extracts I would expect the effect to be as you say, insignificant.

Remember, there's always the chance that the odd occasion may be unexpectedly stronger, perhaps because of 'hot' seeds from natural variations in alkaloid content, as well as in vivo neurological and metabolic fluctuations.
 
3 grams of syrian rue finely ground was not substantively effective as MAOI, swallowed with water and no sublingual on mostly empty stomache, at 50 minutes and 75 minutes.
 
Transform said:
I've quidded whole seeds in sub-gram doses a lot, and the effect is subtle at the most. I haven't any specific accounts to share of combining it with vaped DMT, but based on comparisons with a rue brew and oral 'light' extracts I would expect the effect to be as you say, insignificant.

Remember, there's always the chance that the odd occasion may be unexpectedly stronger, perhaps because of 'hot' seeds from natural variations in alkaloid content, as well as in vivo neurological and metabolic fluctuations.
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I wonder if presoaking the seeds would make it more effective sublingually, have you tried that?

One time during an extraction, i had whole seeds soaked in hot water then a cycle of freeze/thaw, and i tested the liquid and it only had a minimal amount of alkaloids. So i think the alkaloids are not so easily extracted from seeds in the body. Some more force is needed to get them out effectively with boiling and pressing.
 
Sakkadelic said:
I wonder if presoaking the seeds would make it more effective sublingually, have you tried that?

One time during an extraction, i had whole seeds soaked in hot water then a cycle of freeze/thaw, and i tested the liquid and it only had a minimal amount of alkaloids. So i think the alkaloids are not so easily extracted from seeds in the body. Some more force is needed to get them out effectively with boiling and pressing.
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This is a fair point. Quidding dry seeds straight out the packet is likely to be fairly inefficient at first. If you're prepared to keep them in your cheek for an hour until they soften up a bit, there's a whole lot of tasty ( 😁 ) juice comes out with a gentle chew.

Manoeuvring dozens of small seeds around your mouth is a bit of a fine art, and also not really something you'd find me recommending for anyone wearing dentures. The flavour is actually significantly better than a cooked or hot-percolated brew, IME/IMO.

Hot percolation of whole seeds is also decidedly inefficient, so I might try your suggestion of pre-soaking in combination with that. I've given myself quite a challenging surprise a while back after boiling up several combined lots of four-times hot percolated seeds and brewing them with a half hour simmer. The resulting trip leads me to suggest that four percolations only gets about half of the alkaloids out, especially if the seeds are allowed to dry out betweentimes.
 
hyperturtle said:
How much time to presoak? I guess however long to make them mushy? An hour?
Grind, and then presoak?
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An hour might not be enough, but it's simple enough of an experiment just to wait another hour and check again. Ground seeds would require a shorter soak time - you could test that one out for the team ;)
 
4 grams of syrian rue seeds finely ground, then soaked in tepid water for 90 minutes was not substantively effective as MAOI, swallowed with water and no sublingual on mostly empty stomache, at 60 minutes, 75 minutes and 90 minutes.

Imbibing that much bitter grinds takes determination.
 
Hello everyone. Am new here. I apologise if this isn't the correct forum to post this on but I recently followed a DMT extraction guide and have gotton paranoid that my product still contains impurities like Naphtha. It's white and smells sweet almost like candy. Feel like my head get's tension or brain fog when I try smoking my product. I do not want brain damage frame smoking lighter fluid. Much respect y'all.
 
Sloxlattor said:
Hello everyone. Am new here. I apologise if this isn't the correct forum to post this on but I recently followed a DMT extraction guide and have gotton paranoid that my product still contains impurities like Naphtha. It's white and smells sweet almost like candy. Feel like my head get's tension or brain fog when I try smoking my product. I do not want brain damage frame smoking lighter fluid. Much respect y'all.
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This is an typical question for the FAQ official extraction help thread

Post your question there and provide an detailed description on how you extracted your dmt.

Ow and welcome, great to have you here.
 
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