I first took cubensis when they used to be legal in the UK then grew my own for years after they were made illegal, only in the last few years have i started going out and picking wild semilanceata and in my experience i find them to be more medicinal than cubensis, most of us know they are generally more potent by weight but i still get certain desirable effects from dramatically lower doses, i notice what i can only describe as an anti-inflammatory effect from as little as 20 or so liberty caps, but would have to take about 5-7 grams of cubensis to get the same effect which involves a much higher dose of psilocybin (hinting at the possibility there are other factors to consider) it feels like some kind of swelling going down, both mentally and physically
From a more objective standpoint it makes sense that wild mushrooms like semilanceata would have to develop compounds to compete with other wild fungi, and some of these compounds could be good for us humans, they could have anti-fungal, anti-bacterial, anti-microbial, anti-biotic, anti-inflammatory properties which benefit us, i know that it's been shown that semilanceata strongly inhibits MRSA and the reason for the anti-microbial activity is unknown, which by itself says a lot, when growing cubensis in a controlled environment they probably do not have to develop these compounds as much as out in the wild
I'd say the natural is better theory applies, it's only my opinion but Psilocybin Mushrooms are better than LSD, Ayahuasca is better than extracted DMT, and wild mushrooms are better than home cultivated ones, we've all heard this many times, and imo for good reason