I did ecstasy in a dream once, to amazing (but not IRL-like) effect. I also thought I was stoned in a dream, and I seem to remember telling someone when I woke up that it seemed like I was (but not that the effect had carried over into waking life).
My emotions when I'm dreaming are susceptible to transcendence more straightforwardly than when I'm not, so in general I would expect that the emotional power of certain drugs could be replicated in dreams. I was very invested in the LOST series finale, too, and I had what I might as well call a psychosomatic roll while watching it the first time. That is, I was getting MDMA-like effects from watching a television show, and I only knew what MDMA really feels like *two days later* when I rolled in celebration of the fact that the LOST finale didn't disappoint me. (I'd taken ecstasy before, but it hadn't ever actually "worked": at best, I'd felt a very short, happy clarity while rolling, but not the all-out rapture the stuff is meant to invoke.)
I also know of authors, Dante Alighieri and Stephen R. Donaldson, who have written scenes in their stories that sound like signature DMT trips: Dante's Mystic Rose vision at the climax of the Paradiso (reminiscent of the "chrysanthemum") and SRD's "Elohim" characters and homeland in his book The One Tree (these creatures shapeshift in a weirdly lit dimension in ways that sound like the self-dribbling/transforming basketball/elves T. McKenna wrote about, and they're very keen on making "deals" with people). But Dante might've been a straight-lace Catholic and SRD claims to have never done psychedelic drugs. If they've had access to DMT hyperspace without doing DMT, then they either accessed it awake or asleep. Given the prominence in both individuals' lives of the value of dreaming... But either way, the thing is, if those two guys didn't trip on chemicals they took while awake, then either by sheer imagination while awake, or even sheerer imagination asleep, they tripped like they were on something. And if they did it awake, I doubt they couldn't do it asleep. So that's evidence, in my eyes, that it's possible to "break through" without doing drugs, and in dreams.
