Honestly I think this all depends on so many factors. IMHO all these substances have their merit.
But to me personally, of all the substances I had so far, one is really pointing out very strongly: 5-MeO-DMT.
IMHO it's just so different from the others. Not from the typical tryptamine headspace, but it kinda really opens your energy channels (hard to describe) and reunites you with the all.
I just didn't experience any substance even remotely having this effect.
Some say DPT goes into that direction. 2 days ago I vaped some DPT, and although it does have a tremendous body rush I never experienced before (IMHO even stronger than 5-MeO-DMT), which IMHO let's an opioid body high glance into insignificance, it just lacks this transcendental energy bliss completely.
If you would ask me, I would say DPT opens you up to the energies of the lower planes, whereas 5-MeO-DMT opens you to the energy of the high planes. Pure bliss if you can open to it.