Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics

No Tachyphylaxis, ( no tolerance build up )

Linked below - while searching for detail on (Tachyphylaxist- ½life DMT) 2024 paper on why DMT is unique in that it does not induce tolerance to its psychological effects, even with closely spaced repeated use. Studies in humans have consistently shown no significant attenuation in the subjective experiences elicited by DMT. For instance, Strassman (1995, 1996a) demonstrated that volunteers who received four closely spaced doses of DMT experienced no reduction in hallucinogenic intensity (21, 89). Similarly, Dos Santos et al. (2012) observed no tolerance to the subjective effects of two consecutive doses of ayahuasca (22). DMT also does not produce cross-tolerance to other hallucinogens like LSD, further highlighting its distinct pharmacodynamic properties (90–95).

DMT - neuroplasticity, sigma-1 receptor, serotonin 2A (5HT2A) receptor, pharmacology

 

[Transform]

Ah, we have a section specially for science papers. Would you like me to move this thread there and reformat a couple of things accordingly?

 

[Pandora]

I can confirm repeated close spaced re-dosings work perfectly. Also, even with same or lower doses (perhaps there was residue in the pipe?) I frequently find the final experience to be the most intense and most weird of the lot.

 

[TransistorBass]

Also, even with same or lower doses (perhaps there was residue in the pipe?) I frequently find the final experience to be the most intense and most weird of the lot.

This might be my dirty pipe theory, week old DMT pipe funk may bring a gnarly effect versus the freshly cleaned pipe for peace and love.... i need to experiment more.

 

[OccipitalBob]

Ah, we have a section specially for science papers. Would you like me to move this thread there and reformat a couple of things accordingly?

Perfect, thanks. still figuring out the filing system.

I can confirm repeated close spaced re-dosings work perfectly. Also, even with same or lower doses (perhaps there was residue in the pipe?) I frequently find the final experience to be the most intense and most weird of the lot.

there is an element of transparency to the post, the medicine is doing wonders for my PTSD, had a flair up last week and its literally shut it down ( the feeling of relief was and still is palpable. I’ve moved to my RDA, flat wound coils (Squished uniformly flat to provide two little heating tables) just trying to ascertain the best ramp up speed, duration, wattage etc. any clues would be fab it’s kinda working at 35w but my ramp up pattern is too long so I run out of breath just as it’s vaporising

 

[OccipitalBob]

(edit: can’t have been this much) probably more like 35-40mg - need to come down more before I post. bigger dose and got the heat ramp perfect, the two factors combined and I went straight past visuals to synesthesia, felt like I was being smashed with high frequency data, is that when I’m meant to take another hit to breakthrough? I’ve seen some peaks before but that was wild.

If that was the waiting room, it wasn’t as cozy as the 25mg room, do I hold for longer, force myself to take another hit when it’s going ten to the dozen? All subjective I know, but if anyone could offer a basis for comparison that would be ace.

The big question for me is where does all that information come from? detailed multi lane digital cockpit interface, data points, digital alphanumeric displays like layers of holographic parameters running into the trillions

Ta, occy B