joedirt said:Er hum. Maybe you should quit trusting Joe Rogan and start trusting google scholar...
I don't trust Joe Rogan, that's the point.
joedirt said:Er hum. Maybe you should quit trusting Joe Rogan and start trusting google scholar...
Orion said:joedirt said:Er hum. Maybe you should quit trusting Joe Rogan and start trusting google scholar...
I don't trust Joe Rogan, that's the point.
endlessness said:Here are both your articles:
Orion said:joedirt said:Er hum. Maybe you should quit trusting Joe Rogan and start trusting google scholar...
I don't trust Joe Rogan, that's the point.
joedirt said:endlessness said:Here are both your articles:
First off thanks for providing the articles. .. Sorry for the last post...you'd already posted before I could edit it...
You are correct there isn't any "proof", but the evidence is pretty big as far as I'm concerned.
The fact that DMT is found to be produced by enzymes in the rodent brain...and the fact that we find it in the human brain is pretty damn strong evidence as far as I'm concerned. Proof No. Strong evidence yeah. We use Rats as human models all the time and yeah there are some serious differences.
Remember it's easy to get permission to kill a live rat and dissect his brain..it's relatively hard to do with a human brain.
IMO we are at the same point we were with serotonin prior to LSD. Back then we knew serotonin was produced in the gut, but had no idea it was produced in the brain until we isolated the brain receptors that LSD bound to...the 5HT class. This caused the scientific community to begin searching for the endogenous brain chemical that hit those receptors...it was serotonin. The exact same thing happened with annandamide...the bodies natural cannabinoid. We learned how THC worked before we found the bodies endogenous ligand.
Just a friendly shit talking bet...nothing more.
Mark my words. There will be proof of DMT produced in the Brain within 3 years. And yes you can rub my noise in it if I'm wrong!
So to the original poster of the thread. I think you have your answer. There is no proof, but quite a few scientists are starting to think it's very likely and the hunt is on.
endlessness said:joedirt said:endlessness said:Here are both your articles:
First off thanks for providing the articles. .. Sorry for the last post...you'd already posted before I could edit it...
You are correct there isn't any "proof", but the evidence is pretty big as far as I'm concerned.
The fact that DMT is found to be produced by enzymes in the rodent brain...and the fact that we find it in the human brain is pretty damn strong evidence as far as I'm concerned. Proof No. Strong evidence yeah. We use Rats as human models all the time and yeah there are some serious differences.
Remember it's easy to get permission to kill a live rat and dissect his brain..it's relatively hard to do with a human brain.
IMO we are at the same point we were with serotonin prior to LSD. Back then we knew serotonin was produced in the gut, but had no idea it was produced in the brain until we isolated the brain receptors that LSD bound to...the 5HT class. This caused the scientific community to begin searching for the endogenous brain chemical that hit those receptors...it was serotonin. The exact same thing happened with annandamide...the bodies natural cannabinoid. We learned how THC worked before we found the bodies endogenous ligand.
Just a friendly shit talking bet...nothing more.
Mark my words. There will be proof of DMT produced in the Brain within 3 years. And yes you can rub my noise in it if I'm wrong!
So to the original poster of the thread. I think you have your answer. There is no proof, but quite a few scientists are starting to think it's very likely and the hunt is on.
But considering DMT is actively transported across BBB, dont you think the fact that it is present in the brain implies nothing at all because even if produced in other places it could still reach the brain?
And then you would have the big trouble explaining how would dmt be produced with the lack of INMT, which was specifically searched for and not found in the human brain. So to start having any plausibility in the hypothesis, I guess the first step would be to find the necessary enzymes for its production.
Which scientists do you say that hypothesize dmt is made in the brain? AFAIK there's only Rick Strassman. Specially to say its "very likely that dmt is produced in the brain", I would like to see any one of them come up front and debate what is their proposed theory regarding dmt bio-synthesis without INMT or review of literature/explanation why it wasnt found in the brain.
joedirt said:1) I already said it's transported across the BBB. But it's also metabolized by MAO VERY fast as well. How much actually makes it to the BBB to get across? How much DMT do you have to eat without an MAOI to get any effects? EDITED>> Bad example. How fast is it metabolized when you smoke it or inject it? How much are you inhaling versus how much is produced externally and brought across the BBB. <<END EDIT
joedirt said:The simplest explanation to me is that if it's found in the brain then it's produced there. Look just because one avenue of study turned up negative certainly doesn't mean that the answer is final. You asked for an alternative theory...well as a first pass guess I would speculate some where in the direction of S-Adenosyl methionine which is a common co-substrate involved in methyl group transfers and it's involved in over 40 metabolic processes that we currently know of. Perhaps you have already explored this direction and I'm off base? Either way just because INMT isn't there doesn't mean that other mechanisms won't be found.... I'm not even going to debate that because science has a history of changing quite often.
joedirt said:2) Rick is certainly the most out spoken scientist about DMT. Plenty of others remain to be unknown at this time. And why would you assume I'd mention names on here to make a point with you? Seriously?
joedirt said:My friendly bet was that there would be proof within a couple of years?
Do we really have to continue this banter?
How does your explanation take in account the fact that dmt is found in many other parts of the body as well? That they are all produced in each place they are found and do not move around because they get quickly metabolized?
Regarding SAMe, its a co-substrate, not an enzyme. You still need the enzyme to utilize SAMe for adding a methyl group to a tryptamine or protein etc. Unless Im getting my facts wrong here.
Regarding science, yeah sure science changes and I never said its absolute proof that DMT isnt produced in the brain, but evidence so far seems to point against it. And if evidence points against it, you better have some good reason to claim you disagree, otherwise where is the limit? Are we going to start arguing that the earth doesnt spin around the sun ? Notice im just using this extreme example to question where do we draw the line.
I mean, if I say that "dmt is being made in my ear by some unknown mechanism, would my claim be enough to deserve researching it? If you would be the one giving grants, what would you require for my application ? I guess better argument than that, right? Like some kind of evidence that dmt may indeed be produced there, some proposed biosynthesis path, the presence of necessary enzymes, the explanation why they werent found yet.
Of course maybe ultimately I may be right and dmt be produced in my ear no matter how unlikely it seems, but I think before we start claiming that it is "very likely", that "its real", and adding that "quite a few scientists are thinking it is very likely" and its important that we give some substance to what we say, wouldnt you agree?
All Im asking here is that when we post in the nexus we try to avoid falling into common misconceptions and speculations and use reliable sources for our claims and good arguments for it. I have nothing against you and I hope you didnt take this as a negative conflict between us, Im glad to have a good dialogue and am ready to learn from your perspective
joedirt said:For those to lazey to follow the links:
endlessness said:Btw Rising Spirit, this has never been a discussion about defining the dmt experience in scientific terms or ignoring the spiritual side. This is a thread about common misinformations or baseless speculations regarding dmt, one of them is that its proven dmt is made in your brain/pineal.
If one wants to speculate or discuss philosophy, feel free, there are appropriate places and moments for it (I appreciate some myself), lets just please be explicit when doing so and not spread subjective ideas or speculations as Truths.

benzyme said:post sources and refs, not anecdotes. unicorns and fairies are not real.
third eye = LOL
benzyme said:How do you know I never experienced it?
I may have experienced it, and realized it for the illusion it was; like blind faith..too many questions, with no real answers.
benzyme said:aha
now what you just wrote makes good sense. I can observe spirituality from the subjective perspective, and it is a grand thing. Takes a lot of discipline, and I have a certain respect for people who can observe its beauty consistently.
Stanislov Grov's 'Holotropic Breathwork' is a very powerful technique, and I think it just may elicit some endogenous tryptamine production, as well as pinoline. I do not know this for certain, but it seems reasonable.
somewhere along the way, I lost it..pursuit of the divine; a more rigid analytical view of the world took over my consciousness, but I hope to regain some of that dormant right-hemisphere mystique sometime in the near future.