4-Fluoroamphetamine

[bomshiva]

don't do it

 

[endlessness]

4-Fluoroamphetamine, AKA para-fluoroamphetamine, 4-FMP or 4-FA, as the name says, is an amphetamine-like substance, with it's particularities. It releases serotonin, is a weak MAOI, and is an inhibitor of reuptake of dopamine, serotonine and norepinefrine, therefore increasing the amount of all of those substances in the neuron synapses (Marona-Lewicka et al 1995). In high doses it could potentially induce overheating and neurotoxicity so if consuming this substance, it would be wise to avoid redosing and very high doses.

It has been found sold as speed in some samples, as well as a small amount of supposed MDMA, DOC and 2-CB samples.

Oral dosages described are:

Low: 50-80mg
Medium: 100-150mg
Strong: 150-300mg

Effects can last up to 15 hours.

The side effects most often described are bruxism (jaw tension), insomnia, appetite lost, nervousness and anxiety. The long term effects are unknown AFAIK.

Regarding the law, it might be controlled in USA due to analogue law but im not sure. It is not controlled in Spain. It is controlled in Lithuania since 2001 and also illegal in Israel since 2007. Im not sure of other countries.

Proceed with caution, test your substances if possible. IMO there are better substances out there but each one to their own

 

[The Day Tripper]

I've had this stuff before. Personally, i don't enjoy it at all recreationally. The few times i took it at doses above 30mg it was euphoric, but the side affects just aren't worth it, and it lasts too long. If you take it expecting a mdma substitute be prepared to be disappointed, its basically a more serotonegenic speedy feeling substance.

However, in very low doses (3-8mg), i find its a decent functional stimulant to be used on occasion. There's not much euphoria at all at that dose, very little speedieness, slight anti-depressant activity, and just overall clean stimulation. Its a good functional stimulant at low doses imho.

Still, amphetamines in general cause alot of stress on the body. 4-fa is no different, whatever it gives you (energy, break from depression, mental focus) i find it takes away later.

But it being an untested RC, closely structurally related to some pretty neurotoxic amphetamines (although 4-fa is supposedly not nearly as neurotoxic as 4-chloro-amphetamine) means its something to use very carefully and infrequently.

As a recreational drug though i find its cons far outweigh the pros.

 

[bomshiva]

IMO there are better substances out there but each one to their own

care to expound?

 

[Botanical Bliss]

I used this stuff several times in different settings. First time was at a Phish show, that was fun. I took it at a festival, that was fun too. I took it in the woods with friends, that was fun too. But then I realized one night (while on a weed tolerance break) that after I came down from it, I felt weird. It's like a "blah" feeling. I was so committed to my tolerance break but I couldn't resist the bowl my friends were passing around because the 4 fa made me feel "blah." The pot made me much better haha. I personally am done with the 4fa, it leaves my body feeling drained afterwards. I loved it at first though

 

[tango]

I'm not sure what the OP's intentions were in posting this, but if it's just for people to leave an opinion, I'd say avoid it. All amphetamines are great at first, but soon enough all you get is the side effects.

 

[Krellogg]

I'm not sure what the OP's intentions were in posting this, but if it's just for people to leave an opinion, I'd say avoid it. All amphetamines are great at first, but soon enough all you get is the side effects.

this. They almost seem like a fad that just some people don't grow out of, I don't really understand the use for amphetamines now when there's nootropics

 

[NorthernGeno]

This sounds like your typical amphetamine, most amphetamines I've done have the same effect on me, the difference between them are how strong the effects are when taken. I used to do a lot of smaller amphetamines like concerta, ritalin, and adderall. I used it first to stay up and do work but then I realized you can get a euphoric high from them. I would do them with friends because you would feel oddly close with them and you would have almost like a special bonding with the people you took the amphetamines with. We would start opening up to each other which made a good long night of discussion.

After a months of doing this the euphoric part of it started to fad and I would just feel uncomfortable and restless. So I moved from smaller amphetamines to speed. I did speed once, it was like concerta multiplied by 100, I did not like it that much. After that I slowly quit my career with amphetamines. I will do them on an off occasion but not as much as I used to by far.

This 4-FA just sounds like the next amphetamine, they are all the same, ones just stronger than the other. Not a healthy substance to get into in my opinion.

 

[Anthimus]

I've taken this compound numerous times and haven't found the negative effects to be overwhelming. Typical of the aforementioned; bruxism, insomnia, and heightened perspiration (a peculiar body odor was observed as well). The toxicity profile of amphetamines is discouraging, however I found the overall effects of p-fluoroamphetamine to be useful in situations involving reading and as a stimulus for getting up early with little sleep.

There was a study published some years back by Purdue University investigating the effects of this compound. I'll quote the abstract and upload the PDF for those who are interested.

The European Journal of Pharmacology 287 (1995) 105-113

The present study was undertaken to compare the pharmacological properties of p-fluoroamphetamine with those of amphetamine and of other halogenated amphetamines, using several in vivo and in vitro tests. These included substitution testing in (+)-amphetamine (1 mg/kg, 5.4 μmol/kg, i.p.)-, (+)-N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine [(+)-MBDB] (1.75 mg/kg, 7.18 μmol/kg, i.p.)-, and 5-methoxy-6-methyl-2-aminoindan (MMAI) (1.71 mg/kg, 8 μmol/kg, i.p.)-trained rats, [3H]5-HT and [3H]dopamine uptake inhibition in whole brain synaptosomes, and changes in striatal extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) as measured by in vivo microdialysis in freely moving rats. In drug discrimination substitution tests, p-fluoroamphetamine fully mimicked (+)-amphetamine (ED50 0.43 mg/kg, 2.11 μmol/kg), whereas ‘no substitution’ was observed in rats traincd to discriminate the serotonin (5-hydroxytryptamine, 5-HT)-releasing agents (+)-MBDB or MMAI from saline. p-Chloroamphetamine did not substitute for amphetamine but fully substituted for the (+)-MBDB and MMAI cues (ED50 0.17 mg/kg, 0.82 μmol/kg, and 0.14 mg/kg, 0.69 μmol/kg, respectively), p-Fluoroamphetamine, in comparison with p-chloroamphetamine and p-iodoamphetamine, showed much stronger inhibition of [3H]dopamine than [3H]5-HT uptake into rat brain synaptosomes but was less selective than amphetamine. p-Fluoroamphetamine (7.0 mg/kg, i.p.), 1 h after administration, strongly elevated (849% of baseline) extracellular dopamine in rat striatum measured using in vivo microdialysis. Amphetamine (2 mg/kg, i.p.) increased extracellular dopamine in rat striatum with a maximum at the same time as did p-fluoroamphetamine, but the latter gave a smaller increase. The data presented suggest that p-fluoroamphetamine resembles amphetamine more than it does the 5-HT-releasing type amphetamines.

 

[bomshiva]

druqks don't tend to satisfy me much anymore, I prefer a clear mind

 

[Untm]

Clear minds can't spell.

 

[NorthernGeno]

I like how bomshiva changed his original post! Gave me a good chuckle, bad experience or is it just a lame substance all together?

 

[Untm]

I would say otherwise but I have course work to do an I'll give my full response on fluorinated amphetamines later.

Though I have to say this compound sure beats the neurotoxic d/l-amphetamines they hand out like candy in the US.

Regards

-Untm

 

[flowersniffer]

I was tempted to try this along with some other rc's that piqued my interest (not all at the same time!) and found it not too bad.

I haven't done any speed for years and found this to be a good functional stimulant. I also find that for the first hour or two there are increased empathic feelings similar to mdma, but without those huuuuuuuge rushes that roll your eyeballs back and without any general mindfuckery so you can be very nice and friendly without people knowing that you're on drugs... After a couple of hours I just felt nicely stimulated...if I re dose, then the empathy comes back.

I didn't weigh my doses, but must have dabbed (orally ingested) perhaps 200 mg's throughout the day (I've done it a few times now, but that was my biggest sesh) and didn't really notice any side effects other than a dry mouth, no jaw clenching, or anything...Sleep was possible around 4 hours after my last dab.

I've read that it's not very neurotoxic, certainly less than mdma, it felt very clean when I took it and the empathy was nice, it could be a useful tool for some people.