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5-Meo-DMT... regular tek?

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BananaForeskin

BananaForeskin

I Eat Plant Magic
SWIM discovered a small field of delosperma cooperi that makes his attempts at cultivation look pitiful. Trout's notes say that the tryptamine content in D.cooperi is variable, and there's a lot of 5-Meo-DMT involved most of the time. However, SWIM is such a noob when it comes to hyperspace, that SWIM's not tooo comfortable with the idea of 5-Meo-DMT yet.

Will a regular tek get the 5-Meo-DMT as well as the regular DMT? Or not? Ideally, I'd want the DMT to survive unscathed but I don't really want to be getting a lot of the 5-Meo-DMT. IS there any way to tell if there's a lot of 5-Meo in some freebase alkaloid?
 
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BananaForeskin said:
Will a regular tek get the 5-Meo-DMT as well as the regular DMT? Or not? Ideally, I'd want the DMT to survive unscathed but I don't really want to be getting a lot of the 5-Meo-DMT.
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Most techs will extract both DMT and 5-MeO-DMT.

5-MeO-DMT has an XLogP3 of 1.5 and is more polar that DMT with an XLogP3 of 2.5, so a super non-polar solvent like heptane will extract less 5-MeO-DMT and more DMT.

Also the pKa of 5-MeO-DMT is 9.3. The pKa of DMT is 8.6. That means 5-MeO-DMT is freebased at a higher pH. This allows you to better separate them.

If you do an A/B and use heptane as the non-polar solvent, and freebase at pH 7.6, and extract 10 times with heptane, you'll get most of the DMT and nearly no 5-MeO-DMT. Then you adjust the pH to 10 or so and then extract the 5-MeO-DMT with d-limonene or xylene or DCM.

That will separate them very well, but not their N-Oxides. But heptane will not dissolve any N-Oxides, so the heptane will be virtually free of 5-MeO-DMT and 5-MeO-DMT N-oxide if you do the above and freebase the DMT at 7.6.

At pH 7.6 only 10% of the DMT is freebased at any given time. But once you extract it into the heptane, that changes everything and more than 10% gets freebased. If you extract 10 times, you get pretty much all the DMT.

Note that pH adjustments might be needed depending on what else is present in the mix. The pKa is for isolated alkaloids, not a mix of compounds, so it needs to be used as a general guide only, meaning you might need to use a higher pH than 7.6 in some cases.
 
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Yes, toluene, xylene, and d-limonene have almost identical solvent properties. They are way more polar than naphtha or heptane and pull 5-MeO-DMT very well.
 
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