ACRB orally active without MAOI

[Anarkid]

So I read numerous reports of ACRB being active orally without an MAOI. Needless to say, I was skeptical upon reading these reports and determined that there was only 1 way to find out. So I mixed a few grams of the stuff (reports stated that under 5 grams was enough to achieve the desired effects) with water and drank it. A couple hours later, my suspicions were confirmed and I can say without a shadow of a doubt that I felt absolutely nothing at all.

Just wanted to share this for anyone thinking about trying it. You may want to try it for yourself because you are hard headed like I am, but don't expect any results outside of a bad taste in your extremely dry mouth and a few grams of ACRB wasted.

 

[Ashema]

There aren't any MAOI's in ACRB, so it wouldn't be orally active.

 

[Anarkid]

There aren't any MAOI's in ACRB, so it wouldn't be orally active.

Exactly my thoughts prior to the experiment. I knew it would fail before trying. Just wanted to prove it to myself without doubt so that I could share this concrete knowledge with the world without doubt. I don't know what these people who have posted trip reports of ingesting ACRB alone without an MAOI where experiencing but I assume it was purely placebo.

 

[nen888]

..acacias are not a standardised thing...the amount of NMT varies greatly in A. confusa...so also probably does the potential MAOI in it, 2MTHBC (2-Methyl-Tetra-Hydro-Betacarboline)..though the amount is small, the potency is not understood fully... see: The Acacia Confusa Thread

 

[Anarkid]

..acacias are not a standardised thing...the amount of NMT varies greatly in A. confusa...so also probably does the potential MAOI in it, 2MTHBC (2-Methyl-Tetra-Hydro-Betacarboline)..though the amount is small, the potency is not understood fully... see: The Acacia Confusa Thread

I could see how maybe this is the case. Potency variations are a fact of nature. I can say without doubt that the ACRB I have has no noticeable effects without an MAOI. Maybe I will experiment again in the future with different batches of ACRB. Worse case scenario is that I ingest a small amount of tree bark to no effect.

 

[Entheogenerator]

I knew it would fail before trying.

Perhaps this is why it failed...

 

[Anarkid]

I knew it would fail before trying.

Perhaps this is why it failed...

Perhaps. I did not go in to the experiment with the intention of it failing. I WANTED it to succeed. I had high hopes. I prepared accordingly. I assumed I was going for a ride. It just never came. I went in knowing it would fail due to the chemistry behind it saying it would fail. I try to keep an open mind and all but maybe I did ruin it for myself by assuming it would fail. But then again, the science says it can't succeed.

 

[Entheogenerator]

Perhaps. I did not go in to the experiment with the intention of it failing. I WANTED it to succeed. I had high hopes. I prepared accordingly. I assumed I was going for a ride. It just never came. I went in knowing it would fail due to the chemistry behind it saying it would fail. I try to keep an open mind and all but maybe I did ruin it for myself by assuming it would fail. But then again, the science says it can't succeed.

... except for the science that says it could, and supposedly has for several different people.

 

[Anarkid]

Perhaps. I did not go in to the experiment with the intention of it failing. I WANTED it to succeed. I had high hopes. I prepared accordingly. I assumed I was going for a ride. It just never came. I went in knowing it would fail due to the chemistry behind it saying it would fail. I try to keep an open mind and all but maybe I did ruin it for myself by assuming it would fail. But then again, the science says it can't succeed.

... except for the science that says it could, and supposedly has for several different people.

Well in all my studies I have seen nothing saying that an oral dose of DMT can be active without an MAOI. Now, as for the "what if" scenario where ACRB has an MAOI present in it naturally, I cannot refute that. I have no data (nor do I believe anyone does yet) either confirming or denying this. When it comes to people reporting it works, the placebo effect is a mighty, mighty drug and humans are prone to lying. I know that it did nothing for me in this trial. Could ACRB contain an MAOI? Maybe. I just know that it did not work for me.

 

[Entheogenerator]

Perhaps. I did not go in to the experiment with the intention of it failing. I WANTED it to succeed. I had high hopes. I prepared accordingly. I assumed I was going for a ride. It just never came. I went in knowing it would fail due to the chemistry behind it saying it would fail. I try to keep an open mind and all but maybe I did ruin it for myself by assuming it would fail. But then again, the science says it can't succeed.

... except for the science that says it could, and supposedly has for several different people.

Well in all my studies I have seen nothing saying that an oral dose of DMT can be active without an MAOI. Now, as for the "what if" scenario where ACRB has an MAOI present in it naturally, I cannot refute that. I have no data (nor do I believe anyone does yet) either confirming or denying this. When it comes to people reporting it works, the placebo effect is a mighty, mighty drug and humans are prone to lying. I know that it did nothing for me in this trial. Could ACRB contain an MAOI? Maybe. I just know that it did not work for me.

"Can't" is a strong word. The fact that beta carbolines have been detected in analyzed samples, which may or may not have potential for monoamine oxidase inhibation, combined with the anecdotal evidence stating that A. confusa brews may be active without ingestion of additional MAOI's or RIMA's would indicate that it is possible, but there is so little evidence at this time that any conclusions made would be purely conjecture. One single dose of one single batch of bark is hardly enough evidence to draw any sort of conclusion.

 

[Anarkid]

"Can't" is a strong word. The fact that beta carbolines have been detected in analyzed samples, which may or may not have potential for monoamine oxidase inhibation, combined with the anecdotal evidence stating that A. confusa brews may be active without ingestion of additional MAOI's or RIMA's would indicate that it is possible, but there is so little evidence at this time that any conclusions made would be purely conjecture. One single dose of one single batch of bark is hardly enough evidence to draw any sort of conclusion.

I agree. My results are not "conclusive". As you mentioned, a single batch of bark is not enought to prove anything. Had I tried several different batches taken from trees scattered abroad, maybe then I would use the word "conclusive". I am not discouraging anyone from testing this. Quite the opposite. I wish more people would try it. Then we could gather more data and actually be able to draw a conclusion. Until then, my batch of bark is not active orally without an MAOI. I have another batch en route. When it arrives, maybe I will try again.

Successful ACRB oral usage without an MAOI is possible but unlikely.

 

[SnozzleBerry]

Successful ACRB oral usage without an MAOI is possible but unlikely.

Seems like a premature conclusion to draw from a single test involving a minimal amount of material. Most of the reports I've seen involving oral activity of singular plant decoctions (of A. confusa or M. tenuiflora) do not claim to use less than 5g.

Consider trying larger doses and potentially cold-brewing the material to see if the 2-MTHBC comes into play at all.

A. confusa can have a decently similar alkaloid profile to M. tenuiflora, when it comes down to ratios of b-carbolines to tryptamines. M. tenuiflora can be orally active when prepared properly. It seems odd to make such definitive proclamations (even if you acknowledge them as inconclusive) from such minimal investigation.

 

[Ashema]

It would be interesting to know if people with Parkinson's Disease would be affected by your experiment, Anarkid; seeing how they have a mutation in the MAO gene. It would be worth looking into their MAOI effectiveness as well, since clinical depression is a symptom that accompanies Parkinson's and they require MAOI medications.

 

[Anarkid]

Successful ACRB oral usage without an MAOI is possible but unlikely.

Seems like a premature conclusion to draw from a single test involving a minimal amount of material. Most of the reports I've seen involving oral activity of singular plant decoctions (of A. confusa or M. tenuiflora) do not claim to use less than 5g.

Consider trying larger doses and potentially cold-brewing the material to see if the 2-MTHBC comes into play at all.

A. confusa can have a decently similar alkaloid profile to M. tenuiflora, when it comes down to ratios of b-carbolines to tryptamines. M. tenuiflora can be orally active when prepared properly. It seems odd to make such definitive proclamations (even if you acknowledge them as inconclusive) from such minimal investigation.

When my next batch arrives, I have already decided I will try a larger dose. I will definitely post my findings here. Maybe I am jumping to conclusions here but that will not prevent me from further experimentation.

 

[Ashema]

Jumping to conclusions is only bad if you 1) allow it to negatively impact the scientific method and 2) if you say it aloud.
However, metaphysically (and quantum mechanically) speaking, your presuppositions can affect your findings, whether you disclose them or not.

I'll be looking forward to what you find.

Ashema

 

[Anarkid]

I'm going to try a 5g (or larger) dose of the stuff tonight. Report to follow.