Baccharis flabellata

[lobo]

SALVINORINE A AND A SPECIAL PLANT - This is a matter for ISP (Inveterate Specialist Psyconauts). The plant Baccharis flabellata, one of the Brasilian “carquejas”, produces high quantities of a neoclerodane (DACD) which is similar in structure to salvinorine A, and like this is a strong KOR agonist (k-opioid agonist) in the human brain, indeed it resulted it is stronger than salvinorine A. It has been concluded that DACD has an action mechanism similar to salvinorine A. See: Matías Funes et al., 2018, Antinociceptive effect of neo-clerodane diterpenes obtained from Baccharis flabellata, Fitoterapia, vol. 130, pp. 94-99.


I read this from Giorgio Samorini facebook. Anyone know this?

 

[downwardsfromzero]

It's news to me - and it's great to hear about new discoveries.

Link: Redirecting

it is stronger than salvinorine A

Yikes! :shock:

 

[Aum_Shanti]

Really interesting...gotta love nature.

Also interesting:

Our results show that both DAC and DACD possess strong antinociceptive activity, especially DACD which displays a biological effect very similar to that of morphine.

Attached the paper, for anyone interested.

 

[Nydex]

Hold on, so that substance is simultaneously similar to salvinorin A and morphine? Or am I misunderstanding something?

 

[Aum_Shanti]

As I understood it:

The analgesic properties (similar to morphine) were tested in an animal study. But the similarity to "Salvinorin A"'s effects is only so far theoretical. They didn't test this "in vivo", but made molecular simulations.

Anyway it should be noted that we have not yet an experimental evidence indicating that DAC and DACD are binding to the κ-OR

So the announcement from Giorgio Samorini over facebook seems IMHO a bit overenthusiastic, and is lacking IMHO one critically important information, namely that all this data is purely theoretical.

So fingers crossed, the simulations properly translate to "real live"...