well yea of course adding in the tryptamines will help even more. i've done the weekly full dose thing, and when to that i add daily harmalas/caapi/rue the results are better than either on their own
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caapi leaf tea for depression questions
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joedirt said:
Yeah of course it is still good on it's own and I microdosed caapi and rue daily for a year so I was obviously liking it for some time..I dont feel like I need to do that any longer though but weekly use of a tryptamine with some beta carbolines helps keep my mind on track..even if its just changa or some snuffed DMT and harmine.
So i'm on day two now and start noticing results. I forgot how caapi is able to make you feel real minty inside! This inner cooling effect really is something. It's to early to draw a conclusion, but so far i've noticed beneficial effects. I had leaf during the day because it doesn't tire me so much and vine in the evening. Waking up slightly more groggy, but we'll see. Next couple of days will be vine only.
flickedbic
Rising Star
I like to smoke some Caapi leaf with some of the S. tortuosum mentioned earlier along with some Mucuna pruriens mix. Eating a Griffonia simplicifolia seed before bed is fine (safe 5-HTP).
Griffonia tea after green tea/EGCG is mighty fine alone; but combined with the above smoke is a real delight.
Kanna (Sceletium tortuosum) is quite potent even by itself. It is an SSRI so take care with it; you wouldn't mix it with other SSRI's like St. John's Wort.
That said I've had good luck with a common "Good Mood Tonic" that contains extracts of:
Griffonia tea after green tea/EGCG is mighty fine alone; but combined with the above smoke is a real delight.
Kanna (Sceletium tortuosum) is quite potent even by itself. It is an SSRI so take care with it; you wouldn't mix it with other SSRI's like St. John's Wort.
That said I've had good luck with a common "Good Mood Tonic" that contains extracts of:
Well, MAOIs and SSRIs are great - if you like serotonine syndrome and death. Why would you even risk taking caapi with kanna? I appreciate you sharing ideas but this seems like a really bad idea.
Ontopic: I don't know, i feel as if i'm coming down from a psychedelic with this not so pleasant vibration inside that feels a bit like a flu recovery. Mental effects are ok, less anxiety i have noticed. But the stoning effect is really not so enjoyable. I won't take any vine tonight because i woke up in the middle of the night, feeling really bad and dizzy. So far, i've had better results with the leaf alone and it tastes fantastic.
Ontopic: I don't know, i feel as if i'm coming down from a psychedelic with this not so pleasant vibration inside that feels a bit like a flu recovery. Mental effects are ok, less anxiety i have noticed. But the stoning effect is really not so enjoyable. I won't take any vine tonight because i woke up in the middle of the night, feeling really bad and dizzy. So far, i've had better results with the leaf alone and it tastes fantastic.
"I won't take any vine tonight because i woke up in the middle of the night, feeling really bad and dizzy"
That happened me to often when I was microdosing harmalas every night..though I didnt just feel bad or dizzy I would wake up tripping unable to get to sleep..which left me tired and irritable the next day. I did not always wake up dizzy or anything though sometimes just tripping feeling okay but just too awake to sleep..though other times I would wake up with nauseating tracers and stuff.
Dose like that for a year reality can get very very weird man. It's like being psychic or something at times with a serious lack of sleep lol.
That happened me to often when I was microdosing harmalas every night..though I didnt just feel bad or dizzy I would wake up tripping unable to get to sleep..which left me tired and irritable the next day. I did not always wake up dizzy or anything though sometimes just tripping feeling okay but just too awake to sleep..though other times I would wake up with nauseating tracers and stuff.
Dose like that for a year reality can get very very weird man. It's like being psychic or something at times with a serious lack of sleep lol.
christian
Rising Star
realmsundiscovered said:
Honestly, i think the answer to depression is the odd ayahuasca session, and changing your behaviour. I dont think microdosing is the answer, you want a peak experience to get out of that trough, then youll need good diet and regular intense exercise to help you to feel great,etc.
Some interesting links:
Depression:
link.springer.com
www.hindawi.com
Anti-Cancer:
www.hindawi.com
link.springer.com
www.plosone.org
Neuro-Degenerative Disorders
www.hindawi.com
www.plosone.org
Addiction Treatment:
Other:
Short summary of current research on harmine: apjtb.com
Those are all recents studies (last 4 years) on the therapeutic uses of harmala alkaloids. They are getting a lot of attention, and they seem to have a strong antidepressive effect. Take the time to read through, they are all very interesting.
Cheers
Depression:
Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus - Journal of Neural Transmission
A growing body of evidence has pointed to the β-carboline harmine as a potential therapeutic target for the treatment of major depression. The present study was aimed to evaluate behavioural and molecular effects of the chronic treatment with harmine and imipramine in rats. To this aim, rats...
link.springer.com
Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus
A growing body of evidence has suggested that reactive oxygen species (ROS) may play an important role in the physiopathology of depression. Evidence has pointed to the β-carboline harmine as a potential therapeutic target for the treatment of depression. The present study we evaluated the...
Anti-Cancer:
Harmine and Harmaline Downregulate TCDD-Induced Cyp1a1 in the Livers and Lungs of C57BL/6 Mice
We previously demonstrated that <i >Peganum harmala</i> L. extract and its main active constituents, harmine and harmaline inhibit the 2,3,7,8-tetrachlorodibenzo-<i >p</i>-dioxin (TCDD)-mediated induction of the carcinogen-activating enzyme, Cyp1a1, <i >in vitro</i>. However, the effect of...
Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma - Journal of Neuro-Oncology
Harmine hydrochloride (Har-hc), a derivative from Harmine which is a natural extractive from plants, has been considered for treatment of kinds of cancers and cerebral diseases. In this study, we found that Har-hc clearly decreased cell viability, induced apoptosis and inhibited Akt...
link.springer.com
A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells
Activation of p53 effectively inhibits tumor angiogenesis that is necessary for tumor growth and metastasis. Reactivation of the p53 by small molecules has emerged as a promising new strategy for cancer therapy. Several classes of small-molecules that activate the p53 pathway have been...
Neuro-Degenerative Disorders
Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities of β-Carboline and Quinoline Alkaloids Derivatives from the Plants of Genus Peganum
It was reported that the main chemical constituents in plants of genus Peganum were a serial of <i>β</i>-carboline and quinoline alkaloids. These alkaloids were quantitatively assessed for selective inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by <i>in...
β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites
Harmine, a β-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein. The DYRK1A gene is located within the Down Syndrome Critical Region (DSCR) on chromosome 21. We and others have implicated DYRK1A in the...
Addiction Treatment:
Other:
Short summary of current research on harmine: apjtb.com
Those are all recents studies (last 4 years) on the therapeutic uses of harmala alkaloids. They are getting a lot of attention, and they seem to have a strong antidepressive effect. Take the time to read through, they are all very interesting.
Cheers
Well, i don't really need harmalas for that
But it is really psychedelic and differs from other mood altering substances such as cacao in that way. I have noticed an increase in "ideas" or "messages" if you will and some of them are similiar to the messages i get on full brews. For me, they are often about how the body relates to the "soul" or the psyche if you will. About our energy fields and so forth.
For instance, i was meditating and was shown the picture of a human egg about to be fertilized by a sperm. The sperm represented thought and i had to cut it off to stay focused on my breathing...let it wash away so not to have it grown into a "thought baby" of some kind. I have lowered my dose today and so far i'm feeling better.
Why not both if microdoses and small doses provide the guidance you need to follow through with everything?
@Toloache
Great post! I appreciate the contribution...
It's a bit discouraging though, that they have tested anti-depressant effects on rats using a very high dosage. They translate to 900mg harmine for a human around 70-80kg. That seems like an aweful lot. With these studies you always have to keep in mind if they're really relevant. You might be able to prove that inhaling the fecal matter from your colleague farting is unhealthy for your sinus, but does it really make you sick (apart from the smell?) ...- probably not.
Excuse the weird example. I'm just too good at that
Keep in mind there is sort of a conversion from rat to human, if i am not mistaken human dosage is 1/6 (/6,2) of that of rat.. So in this case the dosage of 10 to 30 mg/kg for rat would be converted to 1,6 to 4,8mg/kg for human (so from 112 to 336 mg for the average 70 kg man).
This paper talk about animal to human conversion in great detail:
This paper talk about animal to human conversion in great detail:
embracethevoid
Rising Star
jamie said:
It's a very strong wakefulness promoter and it should be treated in a similar fashion to caffeine. Its mode of action seems to be different. Maybe it inhibits melatonin in some way due to excess serotonin running around; either way it is very good for combatting sleep deprivation. But it can also *induce* sleep deprivation, which is why it's not a good idea to dose it late at night particularly through ROAs other than vaping alone.
Combined with L-tryptophan or even just melatonin, the wakefulness promotion is inhibited it appears. However I don't think it would be wise to dose tryptophan too regularly while under MAO inhibition.
Unlike caffeine it doesn't force you awake at your own expense but it does require you to treat sleep very differently. Sleep becomes something more of a choice than a necessity, which can lead to sleep deprivation if you fall out of your natural cycle due to being unaware of your dosage pattern. It behaves most similarly to Modafinil in my experience. On Modafinil you can get to sleep just fine unlike caffeine but there is a good chance you won't want to! As a result the cumulative effects of sleep deprivation can take you out.
I notice this to be a distinct effect of harmalas when in the system for a long enough period of time (i.e. dosed orally). You will find insights/new angles of perception continuously flooding your mind every few minutes or hours. Very good for mindfulness and exceedingly psychedelic. They go as fast as they come but they just don't stop coming.
Thanks for the links Toloache :thumb_up:
Interestingly: In further studies to seed of P. nigellastrum Bunge, activity-guided fractionation led to the isolation of two new alkaloids nigellastrine I (9) and nigellastrine II (10), and along with eight known alkaloids, vasicinone (1), vasicine (2), harmine (3), deoxyvasicinone (4), deoxyvasicine (5), harmaline (6), harmol (7), harman (8), in which harmol and harman were first isolated from species P. nigellastrum Bunge. As active constituents, all compounds showed good inhibitory activities against AChE.
Wonder if this could lend any clue to the makeup of Harmala Red? How would we isolate these two alkaloids?
