Ingested 12oz grapefruit juice, some homemade berberine tincture, and then immediately started chewing UNK leaves while working in the garden. At some point I got fed up with chewing and decided to look up reports from folks who claim to have felt effects from coleus—most revolved around brewing tea or smoking dried leaves (maybe heat is beneficial). I brewed three cups and drank them over the course of ~90 minutes. Very peculiar how the anthocyanins almost immediately move from fresh leaves into water before it’s even boiling (see attached images).
I experienced that same sleepy feeling while awake, but woke up uneasy and anxious a few times during the night. No OEVs or CEVs; dreaming was not lucid; got ~8 hours of sleep. Fragments of dreams can be remembered, though they were more unhinged and upsetting than usual.
Perhaps there are only physiological effects from the various abietane diterpenoids? These compounds could potentially improve awareness of dreaming at low doses (disrupt deep sleep), but cause physical discomfort at high doses. Or, maybe I overshot inhibition of some CYP450 enzymes by combining grapefruit juice with berberine.
This experiment involved ~20g fresh leaf total (the most I’ve taken so far). I likely won’t feel safe pushing above ~30g fresh leaf if anxiety and discomfort persist. Oddly, I do feel rejuvenated today for whatever reason.