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Datura stramonium: a valuable admixture plant

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polytrip said:
Datura effects last pretty long. Definately longer than any aya/pharmahuasca brew.

The length is dose related. The doses SWIM uses only last 4 hours. Hyoscyamine lasts only 4 hours. Scopolamine lasts only 6 hours. That’s when normal doses are used. But when large doses are taken, they can last up to 3 days or more because they dramatically slow down the digestive system at large doses.

If the effects last more than 4-6 hours, you took too much.

At normal doses, the onset of effects for both hyoscyamine and scopolamine are within 5-30 minutes, peaking at 45-90 minutes. But when large doses are taken, it slows down digestion and so the peak could take many hours to be felt.
 
polytrip said:
I believe that amanita and datura-alkaloïds cancelout eachother. Datura is sayd to be antidote for fly-agaric overdose and viceversa.
Oh yeah, that does indeed sound correct. I might try some Datura and Amanita together, just to see if they really cancel eachother out. :)
 
We all know that datura can be fatal at a certain dose. But what is the precise nature of the toxicity?

-A high dose of lead is deadly, and while a low dose is tolerable, it accumulates in the body and can again lead to death after repeated low doses.
-While smoking tobacco can also be deadly, and is always damaging, but in small amounts the damage is repaired (say, 1 cigarette per week).
-Whereas a tuna sandwich is harmless until overdose (eating too many tuna sandwiches!)

Is datura like lead, tobacco, or tuna sandwiches?!
 
ohayoco said:
We all know that datura can be fatal at a certain dose. But what is the precise nature of the toxicity?

-A high dose of lead is deadly, and while a low dose is tolerable, it accumulates in the body and can again lead to death after repeated low doses.
-While smoking tobacco can also be deadly, and is always damaging, but in small amounts the damage is repaired (say, 1 cigarette per week).
-Whereas a tuna sandwich is harmless until overdose (eating too many tuna sandwiches!)

Is datura like lead, tobacco, or tuna sandwiches?!
All the alkaloids gets metabolized and excreted through the urine in short time, therefore it does not accumulate in the body as lead. To my knowledge, it has never been proven that Datura is always damaging like tobacco. If it is, you propably need high doses quite often, as Datura/Brugmansia and it's alkaloids have been and is still being used both recreationally, medicinally and most important spiritualistic.

Therefore, I believe it is like tuna sandwiches - harmless until you overdose.
 
Evening Glory said:
polytrip said:
I believe that amanita and datura-alkaloïds cancelout eachother. Datura is sayd to be antidote for fly-agaric overdose and viceversa.
Oh yeah, that does indeed sound correct. I might try some Datura and Amanita together, just to see if they really cancel eachother out. :)

No no no no no. Atropine is the standard treatment for muscarinic mushroom poisoning; there are documented cases of persons with accidental Amanita inebriation treated in error with atropine leading to potentiation of the effects. Amanita and Datura have similar modes of action.
 
Oh well, in that case it is even more interesting. Just add 1-3 seeds to combat the nausea from the Amanita, the potentiating of the effects is welcome. ;)
 
Evening Glory said:
All the alkaloids gets metabolized and excreted through the urine in short time, therefore it does not accumulate in the body as lead. To my knowledge, it has never been proven that Datura is always damaging like tobacco.
Thanks. I guess there is also the option that low doses of datura could create minor irreparable damage, that accumulates over time and eventually could become problematic. Anyone know? I ask because SWIM's interest in these magic seeds has been aroused thanks to these threads.

Glad you liked my layman's analoy Traveler, it made me chuckle when I thought it up! :lol:
 
Hyoscyamine, a little scopolamine and traces of atropine are responsible for the effects of Datura stramonium seeds. All of these have been used medicinally for centuries in the forms of herbal pant extracts and more recently as isolated alkaloids. There are no known long term health effects associate with the use of tropane alkaloids.

Look up Levsin. Levsin is just hyoscyamine. Some people use it everyday for years and don’t develop health problems.

Here’s what one manufacturer says about hyoscyamine, “No long-term studies in animals have been performed to determine the carcinogenic, mutagenic or impairment of fertility potential of Levsin; however, 40 years of marketing experience with hyoscyamine sulfate shows no demonstrable evidence of a problem.” Of course sometimes you can’t really trust a manufacturer to be 100% honest about the health risks of their products.

In rats, the LD50 for hyoscyamine and atropine is said to be 500 mg/kg orally. In mice orally the LD50 is 75 mg/kg. The LD50 for scopolamine is 17 mg/kg in rats intravenously. I can’t find the oral LD50 for scopolamine so there’s no way to compare the toxicity of it with the others.

For comparison, the LD50 for caffeine is 192 mg/kg in rats orally. So these tropane alkaloids, even though they have a very bad name, are actually less toxic than caffeine! At least in rats that’s the case.
 
I tried one seed of datura stramonium 1 hour before bedtime a few days back. Only thing I noticed was slight cotton mouth. I did not fall asleep any faster or sleep better. I think I may have woken up more than usual, although I cannot say for sure that was because of the seed or not. Will have to try again some day.

If I get slight cotton mouth from 1 seed, how would 2 or 3 seeds be?
 
Does it alter the mescaline experience to a degree where the spirit of mescaline is lost? My friend from peru doesn't want nausea nor a false first look at mescal.
 
Dagger said:
I tried one seed of datura stramonium 1 hour before bedtime a few days back. Only thing I noticed was slight cotton mouth. I did not fall asleep any faster or sleep better. I think I may have woken up more than usual, although I cannot say for sure that was because of the seed or not. Will have to try again some day.

If I get slight cotton mouth from 1 seed, how would 2 or 3 seeds be?
well hyoscyamine 69ron said is a slight stimulant so that might explain waking up although he did say they cause lucid dreams too.
 
obliguhl said:
Does it alter the mescaline experience to a degree where the spirit of mescaline is lost? My friend from peru doesn't want nausea nor a false first look at mescal.

It changes the experience, making it more LSD-like, more visual, stronger, blocks the nausea, but it still feels primarily like mescaline. Mescaline is definitely the dominant force in the experience. 1-3 Datura stramonium seeds on their own do almost nothing, at most maybe you’ll feel a little stimulated from the seeds. In combination with mescaline, they seem to expand the effects of mescaline not just make it stronger.

The main difference is in the visuals. They look more LSD like and more colorful. The feeling tone of the experience is like that of mescaline with more mescaline style euphoria. There’s a little more mescaline style insight effects. It’s like it boosts all the psychedelic effects of mescaline but blocks all the bodily effects of it. As you increase the mescaline dosage, it becomes more and more mescaline like as the effects of the seeds get overpowered by the mescaline.

It’s an extremely beautiful experience. It feels like mescaline, but with all the positives of mescaline enhanced and all the negatives of it suppressed.

I recommend trying the seeds on their own first. Some people are very sensitive to Datura stramonium seeds and should use just 1 seed. SWIM can take up to 10 seeds before getting any sensation of dry mouth. He usually uses 3 seeds. When taking the seeds on their own, you should NOT feel dry mouth, you should only feel slight stimulation and slight euphoria and an usual feeling in the stomach for the first 20 minutes. If you feel dry mouth, the dose is too high.

Kannamate said:
Dagger said:
I tried one seed of datura stramonium 1 hour before bedtime a few days back. Only thing I noticed was slight cotton mouth. I did not fall asleep any faster or sleep better. I think I may have woken up more than usual, although I cannot say for sure that was because of the seed or not. Will have to try again some day.

If I get slight cotton mouth from 1 seed, how would 2 or 3 seeds be?
well hyoscyamine 69ron said is a slight stimulant so that might explain waking up although he did say they cause lucid dreams too.

Dagger, you’re extra sensitive to the seeds. 1 seed doesn’t cause dry mouth in most people. SWIM needs 10 seeds before he feels dry mouth. Maybe your seed was an extra large seed? How much did it weigh? 1 seed usually weighs about 6-8 mg only.

If 1 seed causes dry mouth, don’t use more than 1 seed.

Kannamate, they are said to work for causing lucid dreams, but SWIM hasn’t experienced that. Datura inoxia however seems to work really well for inducing dreams. I don’t know about lucid dreams, but man, it’s the best sleeping aid SWIM ever used.

Datura inoxia seeds are totally different from Datura stramonium seeds. For one, 3 Datura inoxia seeds have very noticeable sedative effects, very mild psychedelic effects, and definite dream enhancing effects for SWIM. And also, they are larger and cream colored rather than black like Datura stramonium. They look totally different. 3 Datura stramonium seeds produce mild stimulation for SWIM, and no effects on the mind at all. He hasn’t noticed any effects on dreaming from them. But others claim Datura stramonium seeds do induce lucid dreams, but SWIM has never experienced that. It seems like their stimulant effects would be counterproductive.

SWIM has taken 3 Datura inoxia seeds before bed several times now. They are very effective dream inducers and sleep aids. He takes them 15 minutes before bed and as soon as he lies down and closes his eyes he immediately starts dreaming. No kidding. That are that good. They work better than anything else SWIM has tried. With 3 Datura stramonium seeds, SWIM doesn’t feel like sleeping at all and actually finds it hard to drift off into a dream.
 
69ron said:
Dagger, you’re extra sensitive to the seeds. 1 seed doesn’t cause dry mouth in most people. SWIM needs 10 seeds before he feels dry mouth. Maybe your seed was an extra large seed? How much did it weigh? 1 seed usually weighs about 6-8 mg only.

If 1 seed causes dry mouth, don’t use more than 1 seed.
The seed weighed about 10 mg. I felt no mind altering effects from the seed. Only a slight strangeness in my mouth. Also had some thick slime in the back of my mouth when trying to sleep. Kept swallowing.
 
I want to make a simple suggestion for everyones Datura Trials - one could finely Grind 100 Seeds , weigh them and divide the weight by hundred to get the weight of one average Seed -and then double or triple that weight for a Standard dose of seed powder- thats the easiest way to make Sure you always get the Same dose of Datura Alkaloids- as it usually varies from Seed to Seed
 
Dagger said:
69ron said:
Dagger, you’re extra sensitive to the seeds. 1 seed doesn’t cause dry mouth in most people. SWIM needs 10 seeds before he feels dry mouth. Maybe your seed was an extra large seed? How much did it weigh? 1 seed usually weighs about 6-8 mg only.

If 1 seed causes dry mouth, don’t use more than 1 seed.
The seed weighed about 10 mg. I felt no mind altering effects from the seed. Only a slight strangeness in my mouth. Also had some thick slime in the back of my mouth when trying to sleep. Kept swallowing.

It could just be that you’re sensitive to just the drying effect it has on some parts of the body. No blurred vision right?
 
69ron said:
It could just be that you’re sensitive to just the drying effect it has on some parts of the body. No blurred vision right?
Not that I noticed. At least not before 1 hour. Can't say after, since I was in bed trying to sleep. But I did not feel any mental effects.
 
If the dose was too high you'd notice dry mouth, blurred vision, and some minor mental effects at about 45-60 minutes or even earlier.

If you look at the medical profile for hyoscyamine, dry mouth on its own is considered a common side effect for some people and nothing to worry about. Blurred vision tends to happen at a much higher dose, followed by slight mental impairment at higher doses.

Did you use anything else at the time on the same day or the day before?

Have you since tried a higher dose?
 
69ron said:
Did you use anything else at the time on the same day or the day before?

Have you since tried a higher dose?
Did not take anything else that day as far as I know.
Not tried it again. Will probably do so in a few day.

I'd like to get some inoxia seeds. I'd love to get something that actually gives me great sleep. Only thing that ever did that was amanita muscaria. Did not notice any psychedelic effects from it, but man did I sleep well. I felt like I was lulled to sleep on a cloud. Woke up the morning after well rested, which is rare for me.
 
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