The basic theory behind changa is that very small amounts of smoked harmine, even 100 micrograms to 1mg, can effect as much as a 50% MAO-A inhibition and beyond. Furthermore, it is known that caapi extract is 100 to 1000 fold more potent than isolated harmine as an MAO-A inhibitor. (Schwarz et al. 2003) This is why when you use 300mg of Vine or Leaf in 1g of Changa, it can still have a potent effect, not something that many people understand. Because they still think they must always boost the harmine content of changa in order for it to be effective. But if your vine is 1% harmine, 300mg of vine would contain 3mg of harmine. Say if there is 15 medium smoking experience in 1 gram of Changa, this means that 200mcg is in each smoke, plenty enough to effect more than 50% MAO-A inhibition. Even using 300mg of vine per gram of Changa, you can still get 30-40 minute experiences at times. Much of it also depends on the strength of your vine in the first place as well, which of course can vary greatly. This MAO-A inhibition appears to occur as instantaneously, as say, the effects of smoking freebase recreational drugs, such as cocaine or methamphetamine. This MAO-A inhibition enables what previously would be a 5 to 10 minute experience to become more like an 10 to 20 minute experience, or even an experience lasting half an hour to an hour.