DMTripper said:
there are already over 40,000 plant species that have been scientifically classified in the Amazon. So there are over 1.600.000.000 known possible combinations of two plants there and then you have to boil Aya for a whole day for it to work. And the taste.
Still, this is not correct reasoning.
People would first try almost every plant in their surrounding. The number 40,000 tells me nothing. How about trying to think those plants that are sufficiently big to be noticed in the first place? Because a good majority of those 40,000 plants in the list are microscopic plants or not easily noticeable (such as minute grasses and bryophytes).
Both caapi and viridis are fairly big plants, easy to notice (and identify) and I wouldn't be surprised to find that they were among the first 1000 plants to be bioassayed.
Taste is not a problem neither the quantity nor the fact that you have to boil them for 1 day. That's how it goes:
You want to bioassay a plant, say you chose caapi because it also has an interesting trunk. You try a small amount then by increasing amounts you establish that it is not lethal. Then you go for braver bigger amounts. On way is to smoke it, another way is to boil it because chewing the trunk is not the best idea. So you boil 200 g for some time, strain it, concentrate it down because the taste is vile and drink it in one go.
Amazing! you got visions and beta-carboline like effects. This plant is worth for further investigation. After some time it is established that 50g is actually enough for the effect, no need to suffer the taste of 200g. And if boiled for longer the stronger it will get.
Nothing too extraordinary so far. Then, you try this plant in combinations. First with the other psychoactives you may have identified. Some will make it better, some worse. Then with other plants of the jungle. In the case where psychoactivity of viridis alone had not been observed either in humans or animals (e.g. indigenous people could have watched monkeys eating the leaves and going nuts) it would be one of the few thousand candidates-to-be-tried by the people.
And when the do try it, and experience the effects then it is the birth of aya as we mean it.
The whole process of the evolution of ayahuasca is an iterative as well as interactive one and it did take time, maybe a thousand years. But there are no strange odds as to the invention/discovery of ayahuasca. The mathematics of the 40,000 X 40,000 combinations are a bit naive and misleading in this respect.