DMT combined with Pindolol

[Observant]

I just read about this for the first time ...
Does anyone have experience with the Combination ?

Pindolol - Wikipedia Will Metoprolol do the same thing?
Do you think its a safe combination?

 

[corpus callosum]

There are significant differences between pindolol and metoprolol, with metoprolol lacking Intrinsic Sympathetic Activity (ISA- at higher doses pindolol actually has a stimulant effect on B receptors).Metoprolol acts more selectively on B1 receptors and AFAIK, has no effect on 5HT1a receptors;pindolol has a mixed but weak action on these receptors.DMTs main effects are mostly 5HT2a receptor-mediated.

Are you on either pindolol or metoprolol for some medical ailment?I think this is more important to consider than the actual DMT/Beta blocker interaction which is not usually problematic.

 

[Observant]

I am not on beta blockers ,its just out of interest trying to find out if this idea is worth trying or rather dangerous for the Cardiovascular system.

I have seen Pindolol listed as a possible /known Combination with the Spice thats why i was interested if there where beneficial effects to expect.

It seems the stuff is sometimes prescribed for Stage Fright/Performance anxiety /Depression.
Maybe it blocks the fast heartbeat of a spice experience allowing a more calm experience.