I recently had my first 2 experiences with DMT and found them to be the most powerful and profound experiences of my life. I went in believing that I would be experiencing nothing more than my own brain's power, I came out convinced that DMT is a gateway to a place where we're dealing with beings that have a mind and an intelligence separate of our own.
I wrote a little about my experience in a thread here, I encountered an entity that healed me and allowed me live fully again, since that experience I have noticed that not only do I not really experience negative emotions for long anymore but a few years ago I lost hair through stress, the hair follicles died and I was told that it would not regrow in those areas, as of this week I have stubble growing through in those areas.. I am pretty sure that this could only be down to whatever the entity did to me, trust me i've tried to do it myself for years..
That being said I still would recommend great caution in these experiences. A friend of mine that had agreed we would keep these experiments between just the two of us decided to share a bit with some girl one night that didn't really know what it was. We'd both done years and years of research before our experiences and this poor girl was jumping in blind. She has been a shell of her former self since apparently and everytime he tries to ask her what happened she breaks down crying, all that i've heard is that when she opened her eyes towards the end of her experience, a hand came down through the ceiling, she refuses to say anything more.
I think there's definitely a need for a lot of preparation for experiences like this.