Even established psychedelics that we consider to be "safe" haven't really undergone much in terms of a highly structured scientific study evaluating them on all levels of usage and dosage. Do we actually know the long term health effects (maybe 10 to 20 years) of daily smoked DMT or bufo? Do we know the long term effects of cacti or lsa? No, not really, we do know that there are cultures that use these things on a frequent basis, and will often use this as support for their safety "the natives have been using this for centuries", but that's about as detailed support as saying, "well, they obviously didn't all die from it, so it must be safe". I'm not sure how you derive any more comfort from such reasoning, but I do think it is somewhat short-sighted to suggest that RC's in general are dangerous. Somewhat like the blanket statement of saying drugs are dangerous, you group them up and polarize them into black and white and say these are good, these are bad, when the actual story requires a much more complex understanding (these are bad when mislabeled, stuck up the nose, taken in exorbitant amounts, while these others ones are bad when taken by pregnant women, or individuals with heart problems).
Here's an interesting thought, if our knowledge of some of these research chemicals developed in a way similar to our knowledge of DMT, would you be more likely to try them? That is, if after having synthesized these chemicals, we discover they already exist within nature. We discover a concoction made from some rare succulent used by some native group who claims to have had the wisdom of the plant passed down to them from their ancestors. Ship it back to civilization, test it out, and golly gosh it's full of 2c's. They use it ceremoniously and as a shamanic tool. If this scenario played out, would you be more willing to ingest these chemicals? If so, for what reasons? (for me it would be being able to do the extraction myself)
I agree with most everyone who has posted here, and am not trying to convince anyone that these are safe, but I am trying to suggest that most all of us who use psychedelics for long periods of our lives, are treading through murky water as well, regardless of the psychedelic, the majority of the research just hasn't been done. Even with something like LSD which has undergone a fair amount of research, we still don't have very solid ground to stand on, much of the research is misleading. A good example is
this heavily referenced debate over the health effects of LSD, make sure to make it down to the comments section, where most of the original post is refuted.