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Does anyone know the pKa of LSA (d-lysergic acid amide, ergine)

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69ron

69ron

Esteemed member
The pKa of LSD is known to be 7.8.

I've been searching and searching and can't find the pKa of LSA mentioned anywhere.

Does anyone know the pKa of LSA (d-lysergic acid amide, ergine)?
 
Alright I've done a little searching and this is what i've found.

The pH of LSA is around 8, and its pKa is around 7.8

And that's it. That was from here http://www.drugs-forum.com/forum/archive/index.php/t-43529.html

So it cannot be confirmed. But there really is no info out there on this substance. Could you work progressively backwards, using slightly higher and higher PH until all the LSA is basified and can be extracted? And then when you find out what PH it takes to completely basify LSA you could calculate the pKa. IDK, I'm grasping at straws.

But I have a question for you. At what temperature does LSA degrade?
 
I don't think the pKa of LSA is 7.8. That's the pKa of LSD. I believe someone got it confused with LSA and posted inaccurate information.

I don't know the point at with LSA decomposes from heat. It seems to withstand boiling water (100 C) for 5 minutes or so, but eventually comes apart in it. It can withstand boiling acetone (56 C) for many hours. SWIM uses boiling acetone to extract LSA from HBWR in a Soxhlet. It works really well for that. Boiling MEK (79 C) also seems to work well for extracting LSA from HBWR without decomposing it. But that doesn't tell us much about freebase LSA, because the LSA in HBWR is not freebase (unless the pKa is really low, and I highly doubt that).
 
Yeah, I'd figured someone just posted incorrect info since that is the pKa of LSD. And thanks for letting me know that the acetone pulls are done with a sohxlet, it seemed as if your extraction tech was incredibly work intensive for an extract but that takes alot out of it. Does SWIY do this extract under red light or is LSA fairly stable in normal lighting conditions?
 
69ron said:
The pKa of LSD is known to be 7.8.

I've been searching and searching and can't find the pKa of LSA mentioned anywhere.

Does anyone know the pKa of LSA (d-lysergic acid amide, ergine)?
Click to expand...
Grunt! No reliable sources seem to mention it anywhere!
 
VisualDistortion said:
Yeah, I'd figured someone just posted incorrect info since that is the pKa of LSD. And thanks for letting me know that the acetone pulls are done with a sohxlet, it seemed as if your extraction tech was incredibly work intensive for an extract but that takes alot out of it. Does SWIY do this extract under red light or is LSA fairly stable in normal lighting conditions?
Click to expand...

Using a Soxhlet is pretty simple. It’s not a lot of work. It’s all automated.

SWIM’s yields have been roughly 1/2 what they should be according to the literature. He does the extraction in normal light. Maybe some is destroyed by the light? Maybe some is lost from all the excessive defats, washes, maybe his seeds aren’t the most potent, he doesn’t really know. But since the seeds are so cheap, he doesn’t really care if there is actually any loss of LSA. He’d rather have a pure product with some loss in yield, than a high yielded product with lots of contaminants.
 
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