Dosage for a shrooms-like experience on ayahuasca?

[TiramisuVodka]

By shroom like i mean in intensity/control over the trip(if it were a 3g shroom trip/normal dose), i have some syrian rue seeds and some freebase dmt.
Also what would be the differences in terms of effects?

 

[_Trip_]

I think you'll find plenty of information on nexus about the differences between the 2 if you do a quick search. To better control and dose your trip I would suggest extracting the harmala. Otherwise you could experiment with 3-5g of seeds and start at 50mg of dmt. Timing is important for getting it to 'kick' right. Some recommend a wait of 30mins between the seeds and dmt dosing. Which sounds reasonable.

 

[TiramisuVodka]

Okkay great thanks for the infos!
I'm not in mesure of extracting harmala unfortunately so i'll make my self some tea.
About the dosage you mentioned, it will be as intense as a normal mushroom trip, right?

 

[_Trip_]

It's a good start dose, everyone reacts differently to different substances and doses.

 

[Transform]

Okkay great thanks for the infos!
I'm not in mesure of extracting harmala unfortunately so i'll make my self some tea.
About the dosage you mentioned, it will be as intense as a normal mushroom trip, right?

Don't know if you've tried this yet, but it may be worth familiarising yourself with the effects of the rue first. Depending on your size, 3 - 5 g of rue seed can be quite intense. I've had some powerful experiences above 3.5g rue alone, but then I'm only about 140lb (65kg) or so, so your size ought to be measured up against that.

There's also a reverse tolerance with harmalas; in my case, I found that 2.8g was a sweet spot after several weeks of regular dosing.

 

[Phenethylamine23]

MAOI is basically antidepressant. 3g of syrian rue is just a high dose of antidepressants. Although banisteriopsis caapi alone is considered traditional ayahausca and therefore basically high dose antidepressant, I dont think alot of MAOI is needed at all to activate DMT orally. Probably 500 mg.

Considering regular dose for prescription antidepressant is about 25 - 50mg daily? I recommend caution using high dose MAOI.

 

[brokedownpalace10]

MAOI is basically antidepressant. 3g of syrian rue is just a high dose of antidepressants. Although banisteriopsis caapi alone is considered traditional ayahausca and therefore basically high dose antidepressant, I dont think alot of MAOI is needed at all to activate DMT orally. Probably 500 mg.

Considering regular dose for prescription antidepressant is about 25 - 50mg daily? I recommend caution using high dose MAOI.

A prescription antidepressant is a different drug, isn't it? (I'll leave the rest of the post alone)

 

[_Trip_]

Yes there's many classes of antidepressants tricyclic, snri, ssri, and maoi just to name a few. Maoi's are a bit out of date as a antidepressant due to other drug and food interactions. Technically harmala (harmine and harmaline) is a maoi but it's a reversible maoi a RIMA. Making it slightly less dangerous in regards to interactions but caution still must be used.
200mg of harmala is a good dose for inhibition for pharmahusca which at 3-5% harmala alks in syrian rue is roughly 3.5-5g of rue seeds.

 

[Phenethylamine23]

A prescription antidepressant is a different drug, isn't it? (I'll leave the rest of the post alone)

All antidepressants, prescription or plant based, are basically the same in that they work to increase monoamine neurotransmitters in the brain such as serotonin, dopamine and norepinephrine. Reverable inhibitors are less dangerous than irreversable inhibitors. Obviously plant based more natural. I was surprised to discover that ayahausca vine is essentially high dose antidepressant, in the modern sense, but supposedly needed to make the admixture DMT orally active. My point is using the least amount of MAOI necessary to allow DMT to become orally active.

From experience 100 -300 mg of straight powdered syrian rue insufflated is enough to potentiate many psychadelic substances.

 

[brokedownpalace10]

All antidepressants, prescription or plant based, are basically the same in that they work to increase monoamine neurotransmitters in the brain such as serotonin, dopamine and norepinephrine. Reverable inhibitors are less dangerous than irreversable inhibitors. Obviously plant based more natural. I was surprised to discover that ayahausca vine is essentially high dose antidepressant, in the modern sense, but supposedly needed to make the admixture DMT orally active. My point is using the least amount of MAOI necessary to allow DMT to become orally active.

From experience 100 -300 mg of straight powdered syrian rue insufflated is enough to potentiate many psychadelic substances.

They increase those chemicals with completely different mechanisms of action. But regardless, even if they were all MAOI's, different MAOI's have different dosages. So, this isn't really useful.

Considering regular dose for prescription antidepressant is about 25 - 50mg daily? I recommend caution using high dose MAOI.

 

[ABe©eDarian]

50mg of oral dmt after full mao inhibition being the equivalent of about 3g of dry mushrooms sounds about right for some, but it will differ for others.

 

[Transform]

It's similar but different, on account of the intrinsic psychoactivity of the harmala alkaloids. A stiff dose of harmalas can be fully visionary, but in a way that's distinct from the traditional serotonergic psychedelics. The harmala alkaloids are quite 'promiscuous' - they interact with quite a wide range of biochemical systems. This is something which is described in detail in various relevant parts of the forum.

3g of syrian rue is just a high dose of antidepressants. Although banisteriopsis caapi alone is considered traditional ayahausca and therefore basically high dose antidepressant

I highly doubt that pharmaceutical antidepressants would make it onto the official market were they producing visionary effects anything like higher doses of harmala alkaloids. Describing these as "antidepressant" falls way short of the mark. Dale Pendell had the right idea when referring to Peganum harmala with the term "the poison of dreaming".