Effective to orally take harmine & smoke dmt freebase?

[4eversmyle]

As title says, I was wondering if I can take dmt in any method - though I wanted to smoke freebase or diluted with a VG/PG cartridge after taking harmine. I've never taken an MAOI & was researching into the food (tyramine)/drug interactions so I'm taking necessary steps on that. Anyone use this method & what pointers or notes would you say regarding your harmine & dmt ratio, I am planning to start lower on the recommendations for harmine.

much appreciated dawgs of the ever realm

 

[The Sofa Traveler]

I always take oral harmine/harmaline before aerosolized DMT (e-cig juice). It works very fine. The harmine dose is up to you according to how you reel comfortable with it. Recommended is usually in the 100-250mg range (a little lower for harmaline), the higher the dose, the higher the MAO inhibition. For the first time, better start on the low-end dose.
The tyramine containing food is not as important as one might think. These caveats are mostly a legacy from former pharmaceutical MAOIs, which were non-selective (MAO A+B inhibition) and permanent while harmalas are reversible and selective for MAO-A (we usually call them RIMAs rather than MAOIs). This lead to what they called the "cheese syndrome" but it's not much a concern with harmalas. It doesn't mean you should stuff yourself with Parmigiano just before a harmine dose but a moderate amount of tyramine won't hurt you. At worst, excess tyramine will just displace the harmine from its binding site, making it less potent and allowing the MAO tyramine metabolism again (which is anyway also metabolized by the MAO-B in a lesser amount). The risk of accumulating too high level of tyramine in the body is very low with the harmalas as the MAO-A will regain its functions a few hours after intake.
My main rule about food before harmalas is to eat light, digestible, avoiding processed food and fasting 2 hours beforehand. The higher the dose, the more important it would be to apply these rules I think.
Other than food topic, you seem aware of drug interactions you should avoid : SSRIs, MDMA, tramadol, serotonin acting drugs in general as they could lead to serotonin syndrome. That said, a lot of other (pharmaceutical) drugs could be potentiated via the CYP450 inhibition. Among them, caffeine but also various pharmaceutical drugs, according to their metabolism paths. If you're under medication, even if they are not acting on serotonin, you should decrease the usual dose, or in doubt, not take them the day you plan to take harmine.
I'm not sure about your question on the harmine/DMT ratio but it's anyway a good idea to start low with the harmine the first time, just to see how your body reacts. The DMT amount will be the one you want to take according to how you feel comfortable with the experience. You can gradually build you way up with the e-cig, no need for a big unique dose. You could take puffs with few minutes interval and see how it goes, each puff will make you going higher and higher until you decide to stop puffing.
About the timing, you can start puffing the DMT starting from 30-45 minutes after harmine intake but the peak is reached about 1h30 after intake.

 

[copperbubbles]

Since The Sofa Traveler covered safety very well, I'll talk a little about dosing and experience.

It is vital that you know that oral MAOIs will increase the onset time of inhaled DMT. It's a difference between ~5 seconds and ~20 seconds, which might sound small but in experience is absolutely huge, especially if you're used to blasting off. It can also make the same amount of DMT go farther, so by all accounts, go slow with the DMT.

And actually, that's the best thing about doing it this way. You can more slowly get up to your preferred trip without having to stress about getting your hits in in time.

If you've taken enough harmine, you should have a more intense trip from the same amount of DMT. The peak will last a little longer, but the tail will last much, much longer and be more intense than you might be used to. It makes it a bit like LSD, where you start with a big light show and then get a long tail of a psychedelic filter on reality. (But the duration is still on the scale of 30-90 minutes, not 12 hours like lsd.)

It's okay to redose MAOIs during a trip if you aren't satisfied with your dosage. You can also take another hit of DMT at any time too, and it can be very enjoyable to reup every 20-30 minutes and coast like that.

Here's what shulgin says about harmine: Erowid Online Books : "TIHKAL" - #14 HARMINE

 

[TransistorBass]

For me a 50mg dose of Harmalas (Extracted) sublingual about 30-60mins before DMT is about right for an extended and lovely session, go slow on the DMT hits as everything will last 2-3x longer. From my experience 100mg+ harmalas could sit you on your arse and could make you feel a bit sick when trying to move, like a big woozy head.
I enjoy taking repeated 2-3 second hits on the Spice vape, then you can judge how far you want to build the experience or just stay in a lovely trippy meditative state for as long as desired.
Obviously read up on MAOI's to ensure you aren't going to do yourself harm because of a medical interaction with other drugs you may be taking.

 

[windyshaman]

Just started tiptoeing into syrian rue seeds brews by itself or with freebase, only had a couple of freebase trips so far, but both of these were quite eye-opening in all senses. It slows things down quite nicely, but you conscience is better be ready for it. Scared the @#$t out of me the first time around. Even on mild spice doses - overall feeling is quite close to being very deep in on cubes, in the 12g+ region.

 

[Loveall]

30 mg of harmine/THH mix sublingual is ideal for me.

100-250mg seems very heavy to me. Was that sublingual or oral?

For me it is worthwhile to perform the simple harmaline to THH conversion if starting with extracted rue seeds. My experiences have been much better without harmaline.

Sublingual onset is about 20 minutes. I feel a shift and relaxed stare of mind. After that I vape ~ph neutral DMT citrate/freebase mix gently to ease into the space.

All this turns the DMT freebase blast into DMT chill

 

[blig-blug]

100-250mg seems very heavy to me. Was that sublingual or oral?

@The Sofa Traveler will say, but it was almost for sure oral. +200mg is a good spot for oral dosing if you want full inhibition and also strong harmala effects. If one only wants some inhibition for smoking and wants to minimize the harmala effects, sublingual is likely better.

My experiences have been much better without harmaline.

I personally like harmaline a lot. I think if one wants to spin, fly, and change into all kinds of positions in space, harmaline will be welcome. If one doesn't like that or gets too much nausea, then it's better to avoid it.

 

[The Sofa Traveler]

@The Sofa Traveler will say, but it was almost for sure oral. +200mg is a good spot for oral dosing if you want full inhibition and also strong harmala effects. If one only wants some inhibition for smoking and wants to minimize the harmala effects, sublingual is likely better.

Yes, oral of course, as this route was mentioned in thread's title I should have specified though. 200mg orally is also my sweet spot to enjoy harmalas just as such. I'm usually in the 150-220mg range for this purpose. Closer to 150 when I take them several days in a row, closer to 200 or more when taken intermittently. I take them sublingual (about 50-70mg) almost only when I want to extend declining harmalas effects from initial oral dose (as I like to say in French for the rhyme : "quand l'harmal se fait la malle") to take some (more) deemz puffs. I very rarely take them sublingual as such, I feel effects a little underwhelming compared to oral route.