Effects of Exercise on Dopamine Neurotransmission in Parkinson’s Disease

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The Effects of Exercise on Dopamine Neurotransmission in Parkinson’s Disease: Targeting Neuroplasticity to Modulate Basal Ganglia Circuitry

Animal studies have been instrumental in providing evidence for exercise-induced neuroplasticity of corticostriatal circuits that are profoundly affected in Parkinson’s disease. Exercise has been implicated in modulating dopamine and glutamate ...

www.ncbi.nlm.nih.gov

 

[Ulim]

Pergolide - Wikipedia

en.wikipedia.org

There is also lsd for parkinsons

 

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Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease

Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease

 

[Cognitive Heart]

Excellent post. Thanks, tatt!

 

[Aum_Shanti]

In this respect maybe also interesting some of the history of its usage for PD, which is indicated in this paper ("Banisteriopsis caapi, a Forgotten Potential Therapy for Parkinson’s Disease?" ).

(see attached doc)

 

[Bancopuma]

Interesting stuff. The positive effects of exercise are likely due, at least in part, to the effect of exercise on modulating levels of neuronal growth factors, such as glial cell-derived neurotrophic factor (GDNF) which promotes the survival and differentiation of dopaminergic neurons, the neurons lost during the progression of Parkinson's disease. Direct GDNF brain infusions have shown potential but this is obviously a pretty invasive approach.

As well as exercise, it seems like iboga(ine) may be also promising in treating Parkinson's disease, as it has been found to cause a long-term increase in GDNF expression via a positive feedback loop. I made this link a while back, and interestingly recently met and spoke to someone from the Beckley Foundation who is planning to conduct research on this.

Ibogaine, GDNF expression and neurodegenerative diseases - Iboga - Welcome to the DMT-Nexus