Experience with @sabnock1990 discovery about tryptophan+b6 and b12+rue

[Sabnock1990]

Also i need to make sure people understand that for the Folate aspect one needs proper Folate (preferably Methylfolate, but Folinic Acid may work too) and should avoid Folic Acid. Folic Acid causes some issues that proper natural Folate doesn't cause.

So for example, Folic Acid is rate-limited by DHFR, and DHFR is easily saturated by Folic Acid at around approx 200mcgs, if one takes more than 200mcgs of Folic Acid at one time it can overwhelm the DHFR enzyme and then you get unmetabolized Folic Acid going into the bloodstream which then crosses the blood-brain barrier and can strongly bind to Folate Receptor Alpha supposedly approx 10x stronger than Methylfolate, and a lot of unmetabolized Folic Acid can then tie up Folate Receptor Alpha and prevent it from being able to uptake Methylfolate, and if Methylfolate can't get taken up by Folate Receptor Alpha then Methylfolate can't get into the brain and if Methylfolate can't get into the brain it can't give it's methyl group to B12 via Methionine Synthase and thus Methionine Synthase can't produce the Methylcobalamin form of B12, and so that can interfere with Methylcobalamin formation and thus Homocysteine recycling to Methionine, which can then cause low Methionine levels and thus low SAM levels while allowing Homocysteine levels to rise.

So, that essentially means one should preferably avoid Folic Acid as much as humanly possible, especially via fortified foods, which may be hard for some people to cut out of their diet or they may not even think about it or even know that Folic Acid does this. And so if people are consuming Folic Acid, it could interfere with endogenous NMT/DMT synthesis (though one would still get the Tryptamine since that depends solely on B6 and decarboxylation).

So avoid Folic Acid, use Methylfolate ideally or try out Folinic Acid. I know the Methylfolate works for this, but i haven't tested this out with Folinic Acid yet but technically Folinic Acid should work since it doesn't cause the issues that Folic Acid causes.

 

[Sabnock1990]

Like i said, a few simple factors to account for, but so long as all the bases are covered, it'll work.

Maybe i'm just lucky in being able to figure this stuff out, maybe it's the Autism lol, i just hope that others will be able to figure it out as well, it's a pretty simple process to wrap one's head around, just gotta make sure things are done rightly.

 

[Sabnock1990]

Also as far as 5-HTP/Serotonin goes, i've personally experienced higher 5-HTP synthesis due to higher Methylfolate dosages (the same dosages i was taking around the time i figured out the endogenous Tryptamine synthesis thing), and i noticed that higher Methylfolate dosages raised Tetrahydrobiopterin levels higher which then generated a greater amount of 5-HTP and thus Serotonin from Tryptophan, and this was without MAO-A inhibition btw. And yet when i took the B6 with the Tryptophan, again, the B6 decarboxylated Tryptophan fully to Tryptamine, and i did not notice 5-HTP or Serotonin from the Tryptophan even with the higher Methylfolate dosages and thus higher Tetrahydrobiopterin levels, whereas when i didn't take the B6 with the Tryptophan, i noticed the increased levels of 5-HTP and Serotonin.

So again, it seems like once Tryptophan gets decarboxylated to Tryptamine, the process is irreversible, it converts to Tryptamine and can only go forwards along Tryptamine's metabolic path from there. Therefore one won't get 5-HTP or Serotonin, or even Niacin, from Tryptophan if it's taken with the B6, if you could then surely i would've noticed it by now, but Tryptophan with and without B6 seems to produce different metabolites and goes along different metabolic pathways.

I also noticed that when i didn't take B6 with Tryptophan, i would feel the 5-HTP/Serotonin, yet if i took the B6 with the Tryptophan, i wouldn't feel the 5-HTP/Serotonin and so my Serotonin levels would lower overall.

And if i took the B6 with the Tryptophan without MAO-A inhibition involved, i would feel what felt like a slight beginning of Tryptamine synthesis that would be abruptly ended due to MAO-A, and so if i took B6 with Tryptophan without MAO-A inhibition, it would terminate the Tryptamine and then it basically felt like i didn't take any Tryptophan, certainly didn't feel any 5-HTP or Serotonin or Niacin (all of which i have felt from Tryptophan without B6).

 

[harmala_afficianado]

Maybe i'm just lucky in being able to figure this stuff out, maybe it's the Autism lol, i just hope that others will be able to figure it out as well, it's a pretty simple process to wrap one's head around, just gotta make sure things are done rightly.

I think It might be autism+rue, idk how to fully describe it but i can see the impact rue has on you, because it has the same impact on me.

 

[modern]

Have you taken the 8g of rue by it's self? IDK the maybe the rue was stronger than normal?
At 1-1.2g of harmala level the experience provided a full trip. I didn't get fractals like with DMT but did have a vision.
syrian rue is usually 4-6% but maybe you have exceptionally strong seeds at 12%+?

A very high harmala dose and any other Supplement which will change brain chemistry plus an expectation of a certain result can lead to certain experiences.

 

[Voidmatrix]

Have you taken the 8g of rue by it's self? IDK the maybe the rue was stronger than normal?
At 1-1.2g of harmala level the experience provided a full trip. I didn't get fractals like with DMT but did have a vision.
syrian rue is usually 4-6% but maybe you have exceptionally strong seeds at 12%+?

A very high harmala dose and any other Supplement which will change brain chemistry plus an expectation of a certain result can lead to certain experiences.

Totally off-topic, but I need you to stop being a stranger

Always good to see you @modern

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