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Going to a chemistry professor for help / Extraction using Chloroform and Hexane

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Nime

Rising Star
I would like to note that this thread I am posting was derived from my previous one. "Going to a chemistry professor for help / Scientific substitutes for Naphtha.” Now I have narrowed my questions down a bit more.

Through some effort I was able to get a hold of a liter (1000ml) of chloroform. I was said that they also use this same substance to preserve things in, such as organs or what not for display or for learning purposes. Even though I have not gotten hold of Hexane yet, I was told that it is not any trouble finding it here.

So my question is as follows.
What would the correct extraction procedure be with these two substances: chloroform and hexane? How much NaOH shall I use, 1g per 1g of bark? This is what I use when I make an extraction using naphtha. How much chloroform shall I use (how much can actually fit into it)

Let me add this is my first time working with chloroform and hexane, I am not too experienced with chemicals or in the lab; however a chemistry professor is going to supervise me so I don’t end up hurting myself or others. Yet they are not going to be too involved in the actual process of the extraction, he's just gonna kind of watch, cause he is the one thats providing me with the chloroform and we both know it’s not too safe. How dangerous is chloroform and hexane to work with by the way?

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In my previous thread Bufoman wrote:
The best solvents for alkaloid extractions are aromatic solvents like toluene or chlorinated ones like Ch2Cl2 or chloroform. These solvents are hydrophobic but somewhat "polar" ( Polar in a very loose sense as they have electro rich and electro-deficient regions) This will extract everything. Instead of freeze precip just evaporate it all down to an oily residue. Then recrystalizate the residue with hexanes, hexane, heptane, or pet ether.
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So if I do everything the same as I usually do with naphtha (use same quantity of lye, distilled water and root bark), shake, then add chloroform, then roll it around, then after I evaporate it down to that oily residue, the next steo is where I get lost.

So I have the oily residue and I have my hexane, what are the steps and processes I must do now to complete the extraction?
 
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why are you using chloroform, btw?

if you want to know about safety of solvents, google MSDS (material safety data sheet) and solvent name.

I would avoid chloroform. You can get pure dmt with only hexane. Just use it as a straight substitute for naphtha, do everything same as always.

If you insist on using chloroform, then yes, make the pulls with it, evaporate completely. Put oil in glass. Then heat some water, put hexane in the oil glass, submerge bottom of glass in hot water, leave for a few minutes, moving it around a bit. The warm hexane should be picking up dmt and leaving other stuff behind. Take hexane glass off the water, pippette the hexane off the glass away from the oil that stayed in the bottom (or pour the hexane off to another container, but if so, then before dry the bottom of the glass from any water drops, and be careful as some hexane will probably drop off the glass as you pour). Then either evaporate the hexane in the new container all the way, or evaporate till very small amount and then freeze-precipitate it to yield dmt crystals

The oil that stayed behind probably has some other non-dmt actives, but also probably plant oils and other impurities. One can harvest but personally, SWIM would avoid it, unless instead of chloroform he had used limonene, which he would feel safer with
 
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You're planning a STB right? Chloroform will sink to the bottom not float on top as naphtha does. A STB will be a real headache if not impossible because of this property. Not to worry, an A/B is nearly as easy. Because of the greater pulling power of chloroform compared to naphtha, will dissolve a lot more crap, I strongly suggest you perform at least one de-fat on your acid stage before basing and extracting.
 
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endlessness said:
why are you using chloroform, btw?

if you want to know about safety of solvents, google MSDS (material safety data sheet) and solvent name.

I would avoid chloroform. You can get pure dmt with only hexane. Just use it as a straight substitute for naphtha, do everything same as always.
Click to expand...

I would like to avoid using chloroform by all means; from the previous thread I thought I had to chloroform. I must have misunderstood. A simple misunderstanding

I want to use the least amount of chemicals possible and make the simplest extraction. So from what I understand all I need is: distilled water, NaOH, MH root bark, and hexane.

So if I use hexane as a straight substitute for naphtha, will the entire procedure be the same? Meaning if I pop the hexane in the freezer after rolling it around in the bark and basified solution, will it separate just like naphtha. And can I reuse my hexane, just as I do with my naphtha? Or would i have to evaporate it down instead of freezing it and filtering it?

This makes me very happy knowing I don’t have to work with chloroform, a very big relief.
 
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you dont put the basified solution in the freezer, read some more! The hexane will separate like oil separates from water.. then you pull it with a pippete or something, and only once you got the hexane separated, you put it in the freezer. But before freezer, its recommended to pre-evaporate the hexane, so that it is saturated with dmt.. this way more dmt will crash out.

you will learn a lot when actually doing it, theres a lot that is hard to say, only practice shows it.

Be careful, use gloves, safety goggles, and if something doesnt go as expected, before throwing anything away come here and post and maybe people can help you out and save it..
 
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Thank you endlessness, and my sincere apologies for the misunderstanding. That’s what I was trying to ask/say, as I reread my post I realized I wasn’t as clear as I should have been, and my apologies for that, I’ll make a big effort for it not to happen again. As I mentioned before I have made a number of extractions in the near past working with naphtha. Yet, it is my first time working with hexane.

Will heptanes/ heptane work the same way?

I think it is safe to say I will do some experiments and report back in a week.

I must let all of you know how thankful I am to have all of you here to assist me and one another. It really is a refreshing and great feeling. I read the "Attitude" section of this website yesterday morning and was deeply touched. I feel the same way about you all and a lot of other things. Thank you everyone, there is a lot of loving energy all around.

Thank you all.
 
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no problem about the misunderstanding.. I was just trying to make sure you had read enough, its important that people are careful and informed for the whole thing to work good

yeah heptanes will work basically same way also.

report back and feel free to ask any other questions you have. Also no problem about the help, I was also helped with patience when I didnt know much (and still am helped, theres always a lot to learn), so its the least I can do, to help others :)
 
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Hello
I would like to use hexane to extract leach-able components of silicon. I was told that hexane is the best solvent to use for this purpose. But I have no idea how much Hexane i should pour and how long I should keep the silicon in to the hexane. I would really appreciated if you give me some advise on hexane extraction procedure



Nime said:
endlessness said:
why are you using chloroform, btw?

if you want to know about safety of solvents, google MSDS (material safety data sheet) and solvent name.

I would avoid chloroform. You can get pure dmt with only hexane. Just use it as a straight substitute for naphtha, do everything same as always.
Click to expand...

I would like to avoid using chloroform by all means; from the previous thread I thought I had to chloroform. I must have misunderstood. A simple misunderstanding

I want to use the least amount of chemicals possible and make the simplest extraction. So from what I understand all I need is: distilled water, NaOH, MH root bark, and hexane.

So if I use hexane as a straight substitute for naphtha, will the entire procedure be the same? Meaning if I pop the hexane in the freezer after rolling it around in the bark and basified solution, will it separate just like naphtha. And can I reuse my hexane, just as I do with my naphtha? Or would i have to evaporate it down instead of freezing it and filtering it?

This makes me very happy knowing I don’t have to work with chloroform, a very big relief.
Click to expand...
 
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Good to know good know.
It was a very long time ago when I was interested in using the chloroform anywho. But for others interested in it it's good information to be here.
I remember some of the lab proffessor's assistants and co-workers were very hesitant in letting me freely have access to the chloroform, they were afraid I was going to use it for malicious purposes (if you put a soaked rag to "your own" mouth/nose and huff and puff , you will will pass out correct?)


By the way hello there everyone long time now see, I haven't Ben on the forum I a year or two
 
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