GuruD said:
Hi, I don't mean to stray from your topic, but why did you choose the name "nope?"
btw no plants contain LSD, other than that toxic mold ergot which as you know is not really a plant.
syberdelic said:
I will go ahead and jump to the conclusion that no living PLANT in life as we know it would contain any functional amount of LSD
LSD is a product of the laboratory and does not exist in nature. LSD does not naturally occur in any plant, animal, or fungus.
LSD is a synthetic compound, well, it is called semi-synthetic because the lysergic acid precursor occurs in claviceps fungi and the seeds of several species of vines.
Ergot is a fungi of the genus Claviceps, not a mold, and ergot does not contain LSD, rather it contains lysergic acid and other lysergamide alkaloids.
Lysergic acid and lysergamide alkaloids can also be found in, and extracted from, the seeds of several vines in the genus Ipomoea, as well as the seeds of Argyreia nervosa, and Turbina corymbosa, syn. Rivea corymbosa.
There are even ergoline alkaloids found in marine organisms:
Among the prenylated indole alkaloids, ergot alkaloids are a well-established group of natural products, known for their potent and manifold biological activities. Ergot alkaloids have been isolated from terrestrial sources exclusively until Pibocin A (483), the first representative of marine ergoline alkaloids, was obtained from extracts of the Far-Eastern ascidian Eudistoma sp. (Figure 78 ) [205]. Pibocins A (483) and B (484) [206] were found to show antimicrobial and cytotoxic effects against mouse Ehrlich carcinoma cells [205,206]. 2-(3,3-Dimethylprop-1-ene)-costaclavine (485) and 2-(3,3-dimethylprop-1-ene)-epi-costaclavine (486) were isolated from the marine-derived fungus Aspergillus fumigatus, together with known clavine-type alkaloids costaclavine (487) and fumigaclavines A (488 ) [207] and C (489) [208]. Except of fumigaclavine A, all of them were found to show weak cytotoxicity against the mouse leukemia cell line P388 [209]. Additionally, fumigaclavine C (489) was found to induce apoptosis in MCF-7 breast cancer cells [210].
Ergosinine (490), which was isolated from the marine mollusc Pleurobranchus forskalii, is the first ergot peptide alkaloid (ergopeptine) found in marine life. The authors propose that ergot alkaloids may play a defensive or protective role in mollusks and other marine organisms
Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic...
www.mdpi.com
Ergosinine highly resembles ergotamine tartrate, a common precursor for the synthesis of LSD.
Ergosinine (490), which was isolated from the marine mollusc Pleurobranchus forskalii, is the first ergot peptide alkaloid (ergopeptine) found in marine life. The authors propose that ergot alkaloids may play a defensive or protective role in mollusks and other marine organisms
and is also found in a marine organism.
LSD is produced when lysergic acid is subjected to condensation reaction with diethylamine, hence lysergic acid diethylamide.
...Hofmann even conceptualized the idea for the synthesis of LSD by looking at a compound which was produced from condensing nicotinic acid with diethylamine, producing nicotinic acid diethylamide (coramine)
I had planned the synthesis of this compound [LSD] with the intention of obtaining a circulatory and respiratory stimulant (an analeptic).
Such stimulating properties could be expected for lysergic acid diethylamide, because it shows similarity in chemical structure to the analeptic already known at that time, namely nicotinic acid diethylamide (Coramine).
-Albert hofmann; LSD My problem child
Any way, synthesis of LSD seems out of the question in your case, even modern LSD synthesis methods using peptide coupling reagents, which are far more simple than methods of the past, require a fairly high level of education and training in organic chemistry.
Some consume Hawaiian baby woodrose or morning glory seeds, or you can extract the lysergamide alkaloids from these plants and consume them, however lysergic acid and lysergic acid amide produce an intoxication which is far from the psychedelia produced by LSD, and in my opinion these compounds do not qualify as psychedelic, in fact, lysergic acid amide is scheduled as a sedative rather than a psychedelic. I consider consuming these compounds wasting valuable precursors, however, there are some who enjoy these natural lysergamide alkaloids.
-eg