• Members of the previous forum can retrieve their temporary password here, (login and check your PM).

Increasing mescaline absorption

Migrated topic.
w0mbat

w0mbat

Rising Star
SWIM is familiar with the conventional wisdom of chasing mescaline salts with coffee or other things that lower pH of the digestive system in order to enhance absorption of the alkaloids. However, SWIM seems to recall that increasing the amount of the alkaloid in FREEBASE form is what will make it cross the intestinal epithelia faster. And, ofc, one would increase the amount of freebase compound by making the digestive system more BASIC.

So, SWIM wonders: should he take his next dose of mesc acetate with coffee, or with mylanta? Has anyone experimented with these?
 
doesn't anything you ingest in freebase convert to a hydrochloride salt in you stomach???

I just assumed everything that could react in that way would...

am I wrong?
 
It sounds sensible, but it doesn’t actually work that way. I’m not sure why. The pharmaceutical industry has tons of tests on how different forms of drugs have different effects, such that a freebase behaves a little different from an acetate, an acetate behaves a little different from a citrate, and a citrate behaves a little different from a hydrochloride, etc. Because of this, in the USA, the FDA requires that all different salt forms of a drug be tested and approved separately.

This can be backed up by personal experience from many DMT users here. Most of the users have noticed that freebase DMT doesn’t absorb well orally when used with pharmahuasca. Sometimes it’s completely ineffective! So people often add it to juice to form DMT citrate instead of swallowing a freebase DMT capsule with water. DMT citrate works much better than freebase DMT does. You would think that all the DMT would form DMT HCl as it passes through the stomach, but for some reason it doesn’t quite work as expected. I don’t know why.

DMT phosphate is apparently the most potent form of DMT. Many have tested this with pharmahuasca and found this to be the case.

I would love for someone to explain how this works. In pharmahuasca, DMT fumarate, when placed in a capsule works better than freebase DMT put into a capsule. Why? Shouldn’t both form DMT Hcl in the stomach? Why are their effects different? Can anyone explain this?
 
SWIM thought he knew a fair amount about pharmacokinetics but is fairly baffled by this one :) Perhaps freebase DMT is somehow more susceptible to some forms of chemical degradation in the stomach?

I suppose to find out for sure you'd need to do a double-blind study, measuring plasma concentrations and controlling for gastric output of HCl...
 
Back
Top Bottom