Is mixing cacti resin with syrian rue safe?

[Neo-shulginist]

Thanks for all these answers! I really want to have a loong trip and cactis are rare that why I wanted to maximism the effect. But if syrian rue doesn't have synergy I'm not gonna try on my first trip

Mescaline takes longer in higher dosages.
But keep in mind that the beauty of mescaline is not in going hard, but more in the quality of being at ease.
As mescaline is frequently associated with bodily discomfort, those side effects may become more pronounced in higher dosages as well. Personally I haven't found the exact sweetspot, but 300-400 mg of mescaline was fine for a whole day of wonderland.
Keep in mind that it comes on slowly! And disappears almost inconceivably

 

[blig-blug]

There's place for everything! I personally enjoy it more at high doses, although I agree lower doses are very good too. It depends a lot on set and setting. I like to lie down and keep my eyes closed for the first six hours or so; if it weren't possible to do that, I would prefer a lower dose.

IMO the physical side effects can be pronounced but shouldn't be too much of a problem for someone used to *huascas.

 

[Jagube]

I imagine tyramine may be more a problem if they're ingested at the same time.
If the rue is ingested 2 hours after the cactus, the tyramine would have been largely inactivated by gut MAO.

This is not to say it's safe, as there may be other considerations.
I've tried cactus with rue or harmalas a few times, but I didn't go heavy on the harmalas.

 

[ommani]

Having moved past my phobia of otc meds, I’m genuinely excited about combining mescaline/cactus with ibuprofen, in light of the severe headaches that I’ve experienced with it in the past.

 

[brokedownpalace10]

curious now, weed + san pedro, ive only had san pedro on its own. i usually never use weed on psychedelics too.

I don't like weed on acid, but it's fine on Mescaline. I still prefer the cleaner trip without it, but it's nice sometimes too.

Weed on an acid peak clouds things to the point of being dysphoric to me, although it's quite nice on the comedown.

 

[Jagube]

Having moved past my phobia of otc meds, I’m genuinely excited about combining mescaline/cactus with ibuprofen, in light of the severe headaches that I’ve experienced with it in the past.

Might the headaches have been dehydration?

I've had headaches on cactus when I haven't consumed enough water, and it's easy to forget to.

 

[DansMaTete]

Headache is something very common for me when i use mescaline (even well hydrated).

 

[Neo-shulginist]

Having moved past my phobia of otc meds, I’m genuinely excited about combining mescaline/cactus with ibuprofen, in light of the severe headaches that I’ve experienced with it in the past.

Might the headaches have been dehydration?

I've had headaches on cactus when I haven't consumed enough water, and it's easy to forget to.

My experience with phenetylamines is that a lot of them cause headaches. I have personally linked this to muscle tension at the side and front of my head, which I think is caused by muscle contractions triggered by phenetylamines, and possibly linked to serotonin affinity. The word serotonin was coined specifically to refer to contracting blood vessels, so it is not far-fetched to expect that psychedelics may cause smooth muscle tissue contraction.

Acetaminophen / tylenon / paracetamol eases smooth muscle tissue so I'd personally recommend that over ibuprofen. When I use phenetylamines I make sure I have some with me because it helps with the headache specifically, is relatively safe, and causes very little side-effects.

The worst headaches I had was with 2C-I and 2C-T-21. Literally headache so intense it made me cry But acetaminophen worked to make it manageable. I just wish I had access earlier.
With mescaline I did bring some with me so it helped treat moderate headaches more swiftly.