lsd?

[corpus callosum]

Speaking from personal experience I am of the opinion that LSD is a pro-drug.Many moons ago when I aspired to the DMT experience but had absolutely no way of obtaining the said item, I injected LSD intravenously in an attempt to reproduce an experience akin to a psychedelic blast-off.My guestimate of the dose would be 80-100mcg.

There was absolutely NO discernible rush at all.However, I did begin to feel it after about 10 minutes and the time to the peak took approximately 90 minutes as opposed to almost 180 minutes and the peak experience was not noticeably more impressive than taking the same dose orally.Once the peak was reached the tempo of the trip was identical to the oral route.

This suggests excellent oral bioavailability for LSD.

 

[Apoc]

Lsd is no different than other tryptamines, it leaves the body through urine and becomes untestable within a few days. Additionally, your spinal fluid is refreshed several times a day.

SPINAL FLUID!!????? Are you suggesting that they sometimes take spinal fluid to test for substances?

 

[polytrip]

Whenever LSD is consumed, SWIM notices the effects immediately. Pretty much, as soon as it touches his tongue he knows that he ate something that's gonna make him feel a little funny. Visuals start at about the 45 min to 60 min mark. The idea of LSD as a prodrug really excites me and I wish that more research was being done to verify this.
Does anyone have any thoughts on as to why the trip itself is 'wavy'? With upswings and downswings?

Yeah, i also notice the effects immediately. But those are the physical effects. The psychedelic effects always take an hour to kick in.

I think that almost every psychedelic has this wavy character you describe (besdides vaped DMT maybe). LSD has it much more than other drugs though.

Why this is is indeed an intruiging question. As far as i know, you hardly see ever see this effect in other than psychedelic substances. You clearly don't have it with alcohol.
The case of LSD also makes it clear that this effect can't have anything to do with the speed at wich it's entering the bloodstream.

It could ofcourse have something to do with the metabolism of LSD into the substance that realy affects the brain, if LSD is indeed a prodrug.
But it's probably much more complex than that.

 

[trancepants]

Whenever LSD is consumed, SWIM notices the effects immediately. Pretty much, as soon as it touches his tongue he knows that he ate something that's gonna make him feel a little funny. Visuals start at about the 45 min to 60 min mark. The idea of LSD as a prodrug really excites me and I wish that more research was being done to verify this.
Does anyone have any thoughts on as to why the trip itself is 'wavy'? With upswings and downswings?

Yeah, i also notice the effects immediately. But those are the physical effects. The psychedelic effects always take an hour to kick in.

I think that almost every psychedelic has this wavy character you describe (besdides vaped DMT maybe). LSD has it much more than other drugs though.

Why this is is indeed an intruiging question. As far as i know, you hardly see ever see this effect in other than psychedelic substances. You clearly don't have it with alcohol.
The case of LSD also makes it clear that this effect can't have anything to do with the speed at wich it's entering the bloodstream.

It could ofcourse have something to do with the metabolism of LSD into the substance that realy affects the brain, if LSD is indeed a prodrug.
But it's probably much more complex than that.

SWIM has also experienced the wavyness with peaks and valleys on mushrooms, but only once or twice.
Also, if we did discover that LSD was a prodrug, would we be able to isolate the chemicals that do cross the blood brain barrier and are active on the brain?