theAlkēmist
Alchemist
Update #1: Extended the research.
I can get my hands on some and it is not scheduled so I can buy it from a pharmaceutical company at 99% purity.
It’s also produced in the pineal gland. Scientific journals suggest 5-MeO-T is psychedelic. It agonises the following receptors. Can fellow Nexians give input please.
5-HT1B Ki = 35 nM
5-HT1D Ki = 7.3 nM
5-HT1E Ki = 3151 nM
5-HT1F Ki = 1166 nM
5-HT2A Ki = 295 nM
5-HT2B Ki = 16.4 nM
5-HT2C Ki = 52.48 nM
5-HT4 Ki = 501.18 nM
5-HT6 Ki = 69.18 nM
5-HT7 Ki = 5.01 nM
5-MeO-T acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. with no 5-HT3 affinity, so no nausea.
“Based on the criteria applied in this review, LSD and 5-methoxytryptamine are the most potent psychoactive substances”
“Lysergic acid diethylamide, 5-MeODMT and 5-MeOT were found to exert a much more powerful effect on presynaptic (5-HT) neurones”. “these results are in agreement with the reported hallucinogenic potency of 5-MeODMT and suggest that 5-MeOT could also have psychotomimetic properties.”
“DMT may be viewed as an activation process similar to the production of sero- tonin from 5-methoxytryptamine”
www.ingentaconnect.com
“The present study resulted in the isolation of 5-methoxy- N,N-dimethyltryptamine as well as the identification of N,N- dimethyltryptamine and 5-methoxytryptamine. thus confirming the hallucinogenic aspect of V. peruciutra”
“THE COMBINED-MODEL APPROACH FOR STUDYING HALLUCINOGENIC AGENTS We now have at hand two models with which to study the … 5-Methoxytryptamine (5-OMe T), the N-demethylated analog of 5-OMe DMT, possesses a high 5-HT receptor affinity”
“Molecular Orbital Studies on the Conformation of Hallucinogenic Indolealkylamines and Related Compounds. The Isolated Molecules and the Solvent Effectt … Tryptamine hydrochloride 5-Methoxytryptamine S-Methoxy-M^-dimethyltryptamine Psilocybin”
“In this paper we describe the separation of some hallucinogenic indoleamines with detection with a UV photometric and a voltammetric … tryptamine (DMTPA), 5-methoxytryptamine (5-MeO-TPA), 5-methoxy-N,N-dimeth- yltryptamine (5MeO-DMTPA)”
“Selected compounds (5-methoxytryptamine, N,N-dimethyltryptamine, 5-methoxy-N,N-diethyltryptamine and 5-methoxy-N,N-dimethyltryptamine) were … have shown that 5-HT 2 agonism may be responsible for the psychoactive effects of hallucinogenic compounds”
“Preferential action of 5-methoxytryptamine and 5-methoxydimethyl- tryptamine on presynaptic”
“Findings suggest that MeOT may have weak hallucinogenic properties”
psycnet.apa.org
“The role of central serotonergic mechanisms on head-twitch and backward locomotion induced
by hallucinogenic drugs … agents [7,8]. Head-twitch may similarly be induced by the intraven- tricular
injection of serotonin (5-hydroxytryptamine, 5-HT) or 5-methoxytryptamine”
“From the interaction of the hallucinogenic drugs with EF (Table 1) it is clear that apart from LSD they have less effect than serotonin. Tryptamine and simple indoles did not appear to interact with EF. The 5-methoxytryptamine derivatives are of …”
www.nature.com
I can get my hands on some and it is not scheduled so I can buy it from a pharmaceutical company at 99% purity.
It’s also produced in the pineal gland. Scientific journals suggest 5-MeO-T is psychedelic. It agonises the following receptors. Can fellow Nexians give input please.
5-HT1B Ki = 35 nM
5-HT1D Ki = 7.3 nM
5-HT1E Ki = 3151 nM
5-HT1F Ki = 1166 nM
5-HT2A Ki = 295 nM
5-HT2B Ki = 16.4 nM
5-HT2C Ki = 52.48 nM
5-HT4 Ki = 501.18 nM
5-HT6 Ki = 69.18 nM
5-HT7 Ki = 5.01 nM
5-MeO-T acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. with no 5-HT3 affinity, so no nausea.
“Based on the criteria applied in this review, LSD and 5-methoxytryptamine are the most potent psychoactive substances”
“Lysergic acid diethylamide, 5-MeODMT and 5-MeOT were found to exert a much more powerful effect on presynaptic (5-HT) neurones”. “these results are in agreement with the reported hallucinogenic potency of 5-MeODMT and suggest that 5-MeOT could also have psychotomimetic properties.”
“DMT may be viewed as an activation process similar to the production of sero- tonin from 5-methoxytryptamine”
Psychedelic 5-Methoxy-N,N-Dimethyltryptamine: Metabolism, Pharmac...: Ingenta Connect
“The present study resulted in the isolation of 5-methoxy- N,N-dimethyltryptamine as well as the identification of N,N- dimethyltryptamine and 5-methoxytryptamine. thus confirming the hallucinogenic aspect of V. peruciutra”
“THE COMBINED-MODEL APPROACH FOR STUDYING HALLUCINOGENIC AGENTS We now have at hand two models with which to study the … 5-Methoxytryptamine (5-OMe T), the N-demethylated analog of 5-OMe DMT, possesses a high 5-HT receptor affinity”
“Molecular Orbital Studies on the Conformation of Hallucinogenic Indolealkylamines and Related Compounds. The Isolated Molecules and the Solvent Effectt … Tryptamine hydrochloride 5-Methoxytryptamine S-Methoxy-M^-dimethyltryptamine Psilocybin”
“In this paper we describe the separation of some hallucinogenic indoleamines with detection with a UV photometric and a voltammetric … tryptamine (DMTPA), 5-methoxytryptamine (5-MeO-TPA), 5-methoxy-N,N-dimeth- yltryptamine (5MeO-DMTPA)”
“Selected compounds (5-methoxytryptamine, N,N-dimethyltryptamine, 5-methoxy-N,N-diethyltryptamine and 5-methoxy-N,N-dimethyltryptamine) were … have shown that 5-HT 2 agonism may be responsible for the psychoactive effects of hallucinogenic compounds”
“Preferential action of 5-methoxytryptamine and 5-methoxydimethyl- tryptamine on presynaptic”
“Findings suggest that MeOT may have weak hallucinogenic properties”
APA PsycNet
“The role of central serotonergic mechanisms on head-twitch and backward locomotion induced
by hallucinogenic drugs … agents [7,8]. Head-twitch may similarly be induced by the intraven- tricular
injection of serotonin (5-hydroxytryptamine, 5-HT) or 5-methoxytryptamine”
“From the interaction of the hallucinogenic drugs with EF (Table 1) it is clear that apart from LSD they have less effect than serotonin. Tryptamine and simple indoles did not appear to interact with EF. The 5-methoxytryptamine derivatives are of …”
Interaction of Hallucinogenic Drugs with Encephalitogenic Protein of Myelin - Nature
IMMUNOCHEMICAL techniques involving humoral antibody have long been used in elucidating the structural relationships of proteins and small antigenic molecules. Development of a quantitative technique for sensitized lymphocytes with high discriminatory capacity in respect to closely related...
www.nature.com
