Myrrh Terpene isolate (crystalline)

[LiveLaughLove]

back in the day ktbotanicals had this grey crystalline myrrh terpene isolate that was phenomenal. Would any chemistry buffs be willing to help me work up a tek to extract the actives from myrrh essential oil?

 

[Transform]

back in the day ktbotanicals had this grey crystalline myrrh terpene isolate that was phenomenal. Would any chemistry buffs be willing to help me work up a tek to extract the actives from myrrh essential oil?

This would presuppose that the crystalline material is present in the essential oil. A more reliable starting point may be the myrrh resin itself.

As far as separation and isolation goes, testing with a variety of different solvents would show which ones may be optimal for extracting the target substance. This may count as prior art, so a literature search could save you time and materials. I recall seeing a thread or two on this topic at either Drugs Forum or Bluelight, so there could be some level of practical detail to be found there as well.

Another tool in the chemists' arsenal is chromatography, the different forms of which can have powerful roles in the various stages of a separation process, whether as TLC for the earmarking of different fraction or dry flash chromatography for preparative isolation of the extract's frations.

The identification side of things plays a very useful role here if you already know the exact identity of the target compounds. Most of these methods require expensive instrumentation, so I'll spare you the details there for the moment.

From what I recall, a lot of the focus on this myrrh isolate was on account of its opioid agonist properties - does that tally with your experience? If so, can you liken it with a kappa opioid like Salvia divinorum's salvinorin A, or is it more morphine-like? If you still had even a tiny bit of the original isolate that would be incredibly helpful to your quest.

 

[LiveLaughLove]

Sweet, i will do a deep dive on those other forums and see what I can find.
The isolate was akin to a mu-opioid effect rather than a kappa agonist; 75-100mg if the isolate was equipotent to say, 10-15mg of morphine.
as for solvents i think start with Ethanol, isopropanol, and maybe even xylene to see if I can get the full spectrum of alkaloids. Do you think a glass separatory funnel would be helpful for this endeavor?

 

[Transform]

A sepeqratory funnel is only useful if you're partitioning between immiscible solvents. While the myrrh terpene doesn't undergo the same kind of pH-dependent solubrlity changes that alkaloids like DMT does, you may conceiveably need to wash a non-polar solution with brine or basic water at some point.

Please also note, this forum deliberately avoids focussing on certain, more problematic groups of compounds, including μ-opioid agonists. All the same, these are probably 2 of the compounds you're looking for:

2 sesquiterpenes extracted from C. molmol, furaneudesma-1-3-diene and curzerene, have demonstrated activity on CNS opioid receptors

Myrrh Uses, Benefits & Dosage - Drugs.com Herbal Database

Learn about the potential benefits of Myrrh including contraindications, adverse reactions, toxicology, pharmacology and historical usage.

www.drugs.com

Myrrh Uses, Benefits & Dosage - Drugs.com Herbal Database

Learn about the potential benefits of Myrrh including contraindications, adverse reactions, toxicology, pharmacology and historical usage.

www.drugs.com

MyrLiq, a C. myrrha extract with a standardized content of curzerene, furanoeudesma-1,3-diene, and lindestrene (12.31±0.05 g kg−1, 18.84±0.02 g kg−1, and 6.23±0.01 g kg−1, respectively) and a high total furanodiene content (40.86±0.78 g kg−1), was investigated in a pilot study. Volunteers (N=184; age range, 18 to older than 60 years) exhibiting different pain pathologies, such as headache, fever-dependent pain, joint pain, muscle aches, lower back pain, and menstrual cramps, were divided into 2 groups. The experimental group received 1 capsule per day containing either 200 mg or 400 mg of MyrLiq (corresponding to 8 mg and 16 mg of bioactive furanodienes, respectively) for 20 days, and the placebo group was given the same number of placebo capsules. For the male volunteers, pain alleviation was obtained with MyrLiq 400 mg/day for almost all pathologies; for female volunteers, alleviation of lower back pain and fever-dependent pain was observed with only MyrLiq 200 mg/day.