I'm always blown away by the effects that people report from doses that (to me) seem rather small. More and more I'm realizing that I'm a complete outlier with regards to my required doses. I have given my gf 200mg of harmalas extracted from rue on a regular basis for a month or two to help with PTSI, to wonderful effect. The one time I bumped her up to 225mg, she said it was a bit much and got some nausea from it, but otherwise, there were nothing but positive effects according to her.
For me, 200mgs or less is essentially a subconscious dose. It will have mental effects and soothes/relaxes me without any truly noticeable acute effects. From 250-300mg I will feel some very minor "floating" and "stoning" effects, not all that unlike effects from certain strains of cannabis, however, there is no mental fog. In addition, I usually have a general sense of well-being/comfort and feel fairly relaxed, perhaps even slightly sedated.
Between 300-400mg, depending on what I've eaten, if I've exercised and perhaps other factors of that day, I find that the aforementioned effects are enhanced significantly and a level of physical drunkenness begins to set in. Nausea sets in somewhere between 350-400mg, but is barely noticeable and comes in waves, if at all.
From 400-450mg, nausea is common although not overwhelming. Any purging is self-induced and tends to yield little to nothing (depending on what I've eaten, obviously...but the reflex does not feel very "deep" ). I have tracers and undeniable physical drunkenness along with yawning, difficulty reading or focusing on fine motor tasks but am overall functional and have gone out and done manual labor and other activities at this dose.
500-700mg ????
I have dosed myself in the 700-900mg range perhaps 3-4 times, mostly owing to my own forgetfulness when taking pre-measured capsules or dosing before getting a couple hours of sleep and then dosing again after waking up. These experiences have been full blown psychedelic experiences with subtle, yet full visual-field tracers/visuals, near-complete lack of fine motor control, incredibly diminished muscle coordination, full-on repeated purging (on one occasion from both ends), continual yawning, strong auditory hallucinations, dizziness, cramps and the most serene feelings of bliss, joy and well-being once it was all over, in at least 2 cases lasting several days (with one case lasting over a week). I do not recommend or advise taking these doses and cannot imagine what ridiculousness would ensue if any admixture was taken. In reading some of the older ethnobotanical literature that claims that harmalas are not psychedelic by themselves, I can only assume that the researchers in question did not take high enough doses to experience the acute effects that can be induced.